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Biomedical subjects

P Kiilholma

Publications and source records attributed to P Kiilholma.

52 records · Page 3Linked to original sources
PubMed1988

Clinical significance of abnormal nuclear DNA content in serous ovarian tumors.

The nuclear DNA content of 160 serous ovarian neoplasms was determined by flow cytometry from paraffin-embedded tissue. Three (11%) of the 27 histologically benign, seven (16%) of the 43 borderline malignant, and 59 (66%) of the 90 malignant neoplasms were aneuploid (P less than 0.0001). None of the patients with an aneuploid benign or borderline malignant tumor died from cancer, but in carcinomas the DNA index (DI) was a more important prognostic factor in a multivariate analysis than age at diagnosis, stage, histologic grade or ploidy (diploid versus aneuploid). A DI of 1.3 was the most effective value in predicting prognosis; patients with carcinoma with the DI more than 1.3 had inferior survival compared with those with the DI less than 1.3 (P = 0.002). Carcinomas with the DI more than 1.3 were more common in patients older than 60 years at diagnosis (P = 0.0002), and were associated with a low grade of differentiation (P = 0.008) but not with stage. It is concluded that DNA aneuploidy may occur in benign and borderline malignant serous ovarian tumors and that the DI is a highly valuable and objective prognostic parameter in serous ovarian carcinomas.

Adolescent↗
PubMed1988

Incarcerated Richter's hernia after laparoscopy: a case report.

An unusual case of Richter's hernia on the 5th day after laparoscopy is presented. The complaints simulated a postoperative hematoma, but they became so intense that the expansion was surgically explored: a conservative procedure on the loop of small bowel was possible. To prevent this complication after laparoscopy careful shaking of the abdominal wall at removal of the instruments is necessary.

Adult↗
PubMed1987

Modified Pereyra procedure for female stress incontinence.

28 patients were treated with the modified Pereyra procedure for female stress urinary incontinence. In 12 patients this was the primary operative correction of the complaints and resulted in total continence in 10 patients (83%). The other patients had a recurrent stress incontinence which might have contributed to lower success rate of 54% in the total series. Due to less extensive surgery than in suprapubic urethropexy and due to low complication rate we feel that the modified Pereyra procedure is a good alternative as a primary operation for stress urinary incontinence.

Adult↗
PubMed1986

Histological changes in the vaginal connective tissue of patients with and without uterine prolapse.

The histological structure of the vaginal fascia was studied in two groups of patients: 10 consecutive women having a vaginal repair for uterine prolapse or descent and 10 consecutive women having an abdominal hysterectomy for fibroids. Abnormal histological changes were found in 7 out of 10 patients with uterine descent as compared to 2 out of 10 controls (P less than 0.05). This suggests a correlation between histological changes in vaginal connective tissue and pelvic laxity.

Collagen↗
PubMed1986

Serum copper and zinc concentrations in intrahepatic cholestasis of pregnancy: a controlled study.

A prospective, controlled study was undertaken in parturients with normal pregnancy and in parturients with intrahepatic cholestasis of pregnancy (IHC) to assess changes in maternal serum copper and zinc concentrations. Cord serum levels of these trace metals were measured, as well. Copper and zinc were measured by particle-induced X-ray emission (PIXE) analysis on two occasions during pregnancy; and immediately, 5 days and 5 weeks after delivery. Maternal serum copper was significantly higher in the IHC group as compared to the control group at 36-40 weeks of pregnancy and immediately and 5 days after delivery. There were no statistically significant differences between the control and study groups for maternal and cord serum zinc and cord copper concentrations. A positive correlation between maternal serum copper and serum aspartate aminotransferase was observed.

Adult↗
PubMed1984

Trace metals in postdate pregnancy.

Maternal and cord serum calcium, copper, iron and zinc concentrations were analyzed in 20 women with a postdate pregnancy. The control group consisted of 20 parturients with delivery at term and their newborns. Serum free estriol (E3) was also determined. Maternal serum copper, zinc and E3 were statistically significantly lower, while cord serum copper and fetomaternal ratio of zinc were significantly higher in the study group than in the control group. Further, a positive correlation between E3 and maternal serum copper level (r = 0.63) was found.

Adult↗
PubMed1984

Maternal serum copper and zinc concentrations in normal and small-for-date pregnancies.

Serum concentrations of copper (Cu) and zinc (Zn) were determined in 20 non-pregnant healthy menstruating women and in 20 pregnant women during the 1st, 2nd and 3rd trimesters and 5 weeks postpartum as a longitudinal study. Also a cross-sectional population of 106 women was studied. Further, Cu and Zn concentrations were measured in 13 pregnant women who gave birth to small-for-date (SFD) infants; this was done during the 3rd trimester of pregnancy. The serum Cu concentration in nonpregnant women was 0.91 +/- 0.19 mg/l. During pregnancy it was significantly higher (1.48 +/- 0.31, 1.91 +/- 0.25 and 2.20 +/- 0.36 mg/l during the 1st, 2nd and 3rd trimesters, respectively) and 5 weeks postpartum it was still higher (1.09 +/- 0.17 mg/l) than in the nonpregnant women. In the cross-sectional population, serum Cu and Zn values were of the same magnitude as in the longitudinal study. When longitudinal and cross-sectional values of serum Cu during the 3rd trimester were combined, the mean level (2.23 +/- 0.40 mg/l) was significantly higher than that in the SFD group (2.06 +/- 0.25 mg/l). Serum Zn in the SFD group (0.48 +/- 0.12 mg/l) did not differ significantly from the normal pregnant values.

Copper↗
PubMed1984

The role of calcium, copper, iron and zinc in preterm delivery and premature rupture of fetal membranes.

Maternal and cord blood samples were collected in 60 cases with or without rupture of membranes before and at term. Serum concentrations of calcium, copper, iron and zinc were determined by proton-induced X-ray emission. Maternal and cord serum ceruloplasmin and maternal hemoglobin were also determined. Mothers with preterm delivery showed significantly lower hemoglobin values than those with delivery at term. Concentrations of calcium, iron and zinc were higher in cord than in maternal serum whereas maternal copper levels were higher than respective cord levels in all groups. The cord copper and ceruloplasmin and also their fetal/maternal ratios were significantly lower in the group with preterm premature rupture of fetal membranes (PROM) than in other groups. Maternal serum zinc and calcium were lower in preterm groups than in term groups. The study suggests a possible role of copper in preterm PROM and of zinc in the initiation of preterm labor, whereas calcium and iron do not seem to be involved in the etiology of prematurity or PROM.

Calcium↗
PubMed1984

Copper and zinc in pre-eclampsia.

Twenty uncomplicated pregnancies, 10 parturients with mild and 10 parturients with severe pre-eclampsia, all with uncomplicated deliveries, were studied. Maternal and umbilical cord serum were checked for copper and zinc by the proton-induced X-ray emission (PIXE) method; maternal serum protein, hemoglobin and estriol were determined as well. Maternal zinc and copper values were lower, whereas the umbilical cord serum copper level was higher in the group with severe pre-eclampsia as compared with the controls. Maternal zinc was also lower in mild pre-eclampsia than in the controls. The possible causes of these changes are discussed in view of the hormonal, metabolic and enzymatic changes in pre-eclampsia.

Copper↗
PubMed1984

Pregnancy and delivery in Ehlers-Danlos syndrome. Role of copper and zinc.

Two pregnancies of a patient with the mitis type of the Ehlers-Danlos syndrome (EDS) were followed up. The first pregnancy ended at 26 weeks. The second one proceeded to term, but the infant had a low birth weight and the placenta showed dysmaturity. In view of these pregnancies, the authors consider the vaginal route as an alternative to caesarean section for delivery of patients with the mitis type of EDS. In connection with both deliveries, serum zinc and copper levels were determined with the method of particle-induced X-ray emission (PIXE); the concentrations of both trace elements were low. The ceruloplasmin levels, on the other hand, were within the normal range. The relevance of these findings is discussed.

Adult↗
PubMed1984

Contrast enhancement versus vasculature of uterine tumors.

The relative contrast enhancement of normal myometrium and small or medium size uterine fibroids and clinical stage I endometrial carcinomas were correlated to their microangiographically demonstrable vascularity. In four cases small uterine fibroids showed contrast enhancement equal to normal myometrium, independent of their vascularity in microangiography. In five, endometrial carcinomas contrast enhancement was always below that of the surrounding myometrium in CT. Intratumour vasculature showed great variability in microangiography. No correlation between the topographic variations in the arrangement or density of tumour blood vessels and the degree of contrast enhancement was found. Contrast enhancement of small uterine fibroids was greater than that of small adenocarcinomas. More contrast material accumulates tissue of the fibroid than into the extravascular space of endometrial carcinoma.

Aged↗
PubMed1983

Colloid osmotic pressure of cord blood in relation to neonatal outcome and mode of delivery.

Colloid osmotic pressure (COP) of umbilical cord blood was measured in 184 infants, 113 of whom were delivered vaginally and 71 by Caesarean section, 152 were born at term and 32 were preterm (gestational age less than 37 weeks). Thirteen infants developed RDS, 20 had transient tachypnoea (TT) and 13 had perinatal asphyxia. There was a significant linear correlation between COP and total protein in cord blood (r = 0.91). Such a correlation was also found between COP of cord blood and gestational age in the non-RDS group (r = 0.49). COP was higher (19.6 mmHg) in the infants delivered vaginally than in those delivered by Caesarean section (16.8 mmHg, p less than 0.001). In the RDS group COP was 13.2 mmHg, in the TT group 15.6 mmHg and in the asphyctic group 16.9 mmHg (normal 18.3 mmHg). COP appeared to be of diagnostic assistance in babies developing neonatal pulmonary maladaptation syndromes.

Asphyxia Neonatorum↗
PubMed1983

Female genital tuberculosis and consequent infertility.

During the years 1971-1980, genital tuberculosis was found in seven patients examined for infertility at the Department of Obstetrics and Gynaecology, Turku University Central Hospital. None of these patients had a previous history of tuberculosis manifestations. Chest X-ray examinations were normal for all patients. Six of the patients had tuberculous endometritis. Infertility was the only one had tuberculous endometritis. Infertility was the only symptom for these patients. The findings for the hysterosalpingogram were varied and generally not typical of genital tuberculosis described in the literature. All diagnoses were confirmed histologically. Two cases of full-term pregnancy after treatment of genital tuberculosis are described. In one case there was a purulent tuberculous salpingo-oophoritis and in the other case there were tuberculous implants at the surfaces of the uterus and ligamentum latum. In addition two cases of extrauterine pregnancy are described.

Adult↗
PubMed1982

Tuberculous peritonitis simulating peritoneal carcinosis.

Two cases are reported exemplifying the difficulties faced in the clinical diagnosis of peritoneal tuberculosis. Two fertile-aged nulliparous females were admitted with symptoms and signs of an acute abdomen. Both showed a relative intestinal obstruction, abdominal mass and ascitic fluid. A malignant disease was suspected and laparotomy was performed. Tuberculous peritonitis was demonstrated histologically in biopsy and later confirmed by positive culture for tubercle bacilli. In the first case the correct diagnosis was disclosed during operation by frozen section, although the histological picture also indicated possible carcinosis because of a heavy mesothelial hyperplasia. A 9-month chemotherapy with isoniazide and rifampicin, supplemented during the first 2 months by streptomycin or ethambutol, was successful in both cases.

Adult↗