Search PubMed⌕ Search

Biomedical subjects

P Khan

Publications and source records attributed to P Khan.

31 records · Page 2Linked to original sources
PubMed1980

A comparative study of salivation in affective disorders.

In two 4-week studies comparing the salivation of neurotic and endogenous patients, they were found to have reduced salivation in comparison to control group, but no statistically significant differences were noted between the neurotic and endogenous patients or when the two groups were compared with normal subjects. There was a statistically significant correlation between parotid salivation and sleep disturbance factor scores of the HAM-D in neurotic patients indicating greater sleep disturbance to be associated with higher salivation rates.

Adult↗
PubMed1980

Relationship between sleep deprivation and urinary MHPG levels.

A 5-day study, forming the initial part of two 32-day clinical trials and involving 22 unipolar depressed inpatients, was designed to determine the relationship between response to sleep deprivation and 24-hour urinary MHPG levels. A statistically significant, positive relationship was noted between the sleep deprivation, modified total HAM-D scores and MHPG levels at postsleep deprivation, indicating that the greater the severity of depression during sleep deprivation the higher were the MHPG levels after the sleep deprivation period.

Adult↗
PubMed1979

Reversible defect of neutrophil chemotaxis and random migration in primary hyperparathyroidism.

Chemotactic and random migrations of neutrophils derived from four patients with primary hyperparathyroidism were found to be defective. These abnormalities improved significantly in parallel with the decrease in serum calcium and parathormone and with the increase in serum phosphorus concentration after surgical removal of the adenoma. These observation suggest a possible role for parathormone phosphorus and calcium in the motility of neutrophils.

Adolescent↗
PubMed1979

Abnormal neutrophil chemotaxis and random migration induced by aminoglycoside antibiotics.

Gentamicin and amikacin, administered in therapeutic doses to normal healthy adults, caused a transient decrease in chemotactic migration of their PMNs. In contrast, RM of leukocytes obtained from these individuals was increased significantly. The magnitude of these changes did not correlate with the serum antibiotic concentrations. Separate in vitro experiments with gentamicin, however, revealed an inverse dose-response relationship with chemotactic suppression. The mechanism(s) involved in modifications of these leukocyte functions is not well understood. These findings may be of clinical significance in patients, especially those with altered host defense mechanisms, who require therapy with these aminoglycoside antimicrobial agents.

Adult↗
PubMed1977

Defects of neutrophil chemotaxis and random migration in thalassemia major.

Chemotactic and random migrations in a group of 11 patients with thalassemia major were found to be defective. This may be partially the basis for the predilection to infection occasionally observed in these patients. These findings may reflect a primary defect of polymorphonuclear leukocytes or may be secondary to associated liver disease and/or diabetes mellitus. Further studies are required to define the mechanisms involved.

Adolescent↗
PubMedDate not supplied

The experience of hospitalization and restraint of women who have a history of childhood sexual abuse.

Within psychiatric settings, many female clients report experiences of childhood sexual abuse (CSA). In this paper we explore the experience of 10 women who were hospitalized in psychiatric settings, restrained, and given forced medication (FM). All the women have histories that included CSA. Some authors have suggested that the experience of psychiatric hospitalization may represent an event that reenacts the experience of trauma. The results suggest that from the perspective of these women, the experience of restraint engendered traumatic emotional reactions such as fear, anxiety, and rage, and in no way was viewed as therapeutic even years later. Women felt powerless and unheard. The women wanted nurses who were empathic and responsive to their human needs as clients, but they felt nurses did not want to hear about the abuse or their internal distress. We hope that the perspective of these women will help in the consideration of alternatives and modifications to the use of restraint in psychiatric settings.

Adult↗
PubMedDate not supplied

Verbal and physical abuse of nurses.

In order to determine the extent to which nurses working in hospitals in the Toronto area experienced abuse, questionnaires were distributed to 2344 nurses working in either a large teaching hospital, a psychiatric hospital or a community hospital. Of the 603 nurses responding to the questionnaire, 199 (33%) had experienced abuse in their last five days at work. There were no statistical differences between the three hospitals in the incidence of abuse. The abuse was mainly verbal, from the patient and during the day shift. Although abuse occurred in all areas of the hospitals and was directed towards nurses with all levels of education, it was most frequently found in extended care and emergency areas and most often directed towards registered nursing assistants (RNAs). Administrators may be unaware of the high incidence of abuse since only 41% of the nurses reported the abuse to their immediate supervisors.

Adult↗
PubMedDate not supplied

All together now....

Explore the source record for details and available documents.

Decision Making, Organizational↗