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Biomedical subjects

P Kes

Publications and source records attributed to P Kes.

At least 73 records · Page 4Linked to original sources
PubMed1982

[Electrocardiographic changes in chronic obstructive lung diseases].

Various patterns and frequency of electrocardiographic changes in patients with chronic obstructive lung disease (COLD), as well as their relationship to the degrees of air-flow obstruction, were investigated. Electrocardiograms and pulmonary function tests were analysed in 302 patients (230 men and 72 women) with COLD, and the results were compared with the results of the same examinations obtained in 86 healthy subjects (63 men and 23 women). The most common electrocardiographic patterns were: a) "P pulmonale", b) right axis' deviation of the P wave, and right axis' deviation of the QRS complex, c) inversion of the T waves in standard (II and III) and in the precordial leads (V1 to V4), d) the presence of a qR pattern with delayed R wave in V1 (V5R) (onset of intrinsicoid deflection more than 0,003 seconds) which was often associated with an incomplete right bundle branch block.--P pulmonale and inversion of the T waves in standard and precordial leads were considered as labile, reversible electrocardiographic changes which do not show any correlation with the severity of COLD. Deviations of the P wave and QRS complex to the right, significantly correlated with the degree of the air-flow obstruction (P less than 0,05) in patients with COLD, but the changes are not sure signs of chronic cor pulmonale. On the contrary, qR pattern with delayed R wave in V1 (V5R) (onset of intrinsicoid deflection more than 0,03 seconds), which was often associated with an incomplete right bundle branch block, was significantly correlated (P less than 0,001) with the degree of air-flow obstruction in patients with COLD and may be considered as highly suggestive for the diagnosis of chronic cor pulmonale.

Bundle-Branch Block↗
PubMedDate not supplied

Influence of renal functional mass on the catabolism of endogenous gastrin in humans.

The influences of renal function and mass on the catabolism of serum gastrin were studied in 27 patients with hypertension caused by unilateral parenchymal renal disease (77.8%), renal artery stenosis (11.1%) and essential hypertension (11.1%). Blood for gastrin analysis was taken by catheterization from the aorta, inferior vena cava, renal veins and cubital vein. Separate renal functions were measured using radioisotope methods and the renal mass was also calculated. Significant differences (p < 0.001) in serum gastrin concentration between the aorta (29.5 +/- 6.7 pmol/l), inferior vena cava (23.4 +/- 5.8 pmol/l) and cubital vein (19.4 +/- 4.5 pmol/l) were found. Extrarenal gastrin extraction amounted to 12.5% and was considerably lower than renal gastrin extraction (20.5%). There was a significant positive correlation between renal gastrin extraction and renal blood flow or renal functional mass. Kidneys have an important, but not exclusive, role in the catabolism of endogenous gastrin in humans. In the catabolism of some, or at least some molecular forms of, gastrin, the capillary systems of extrarenal tissues have an important role.

Adult↗
PubMedDate not supplied

[Acute renal failure, intravascular hemolysis and toxic hepatitis caused by repeated use of rifampicin (case report)].

We report the case of a 57-year-old man treated with interrupted rifampicin therapy for urinary tract tuberculosis who experienced acute renal failure, intravascular hemolysis and toxic hepatitis. This combined adverse reactions are rare. Supportive treatment with dialysis and withdrawal of rifampicin result with complete recovery. Interrupted and intermittent therapy with rifampicin should be avoided and noncompliant patients should be given alternative treatment when possible.

Acute Kidney Injury↗
PubMedDate not supplied

[The effect of degree of renal function damage on the levels of serum gastrin and gastric acid secretion].

Fasting serum gastrin concentrations and both basal and maximum-stimulated gastric acid secretory rates have been studied in 225 patients with various degrees of impairment of renal function and 42 healthy subjects. Basal gastrin concentrations in the chronic renal failure (CRF) patients were significantly higher (p < 0.05) than in control subjects. When the glomerular filtration rate (GFR) was used as an index of the degree of renal impairment serum gastrin rose proportionately with the degree of renal failure. Basal (BAO), maximal (MAO) and peak acid output (PAO) in the CRF patients were significantly lower (p < 0.05) than in the control group. Both in the basal condition and during pentagastrin stimulation the CRF patients had low volume of gastric secretion. There was significant positive correlation between basal serum gastrin concentrations and the severity of renal damage. The basal serum gastrin concentration was inversely related to BAO, MAO and PAO in the CRF patients with severe impairment of renal functions. The results indicate that hypergastrinemia in CRF patients might be due to a combined effect of impaired renal catabolism of gastrin and overproduction of gastrin associated with hypochlorhydria. The present findings suggest that in CRF there are some unknown mechanisms that inhibit gastric secretion.

Adult↗
PubMedDate not supplied

[Renal metabolism of endogenous gastrin].

The kidney was thought to be the most important known site of the metabolism of gastrin. Specific mechanisms for gastrin catabolism in vivo have not been elucidated. Very little of the gastrin that is filtered by the kidney homogenates appears in the urine. The kidney tubule contains enzymatic activity that cleaves the C-terminal dipeptide amide from gastrin tetrapeptide, but it is not known if such an enzyme acts on the lager gastrin molecules. Removal of gastrin from the circulation is too rapid to be caused by any specific organ but rather must, be due to some nonspecific widespread metabolic process, probably existing in circulating serum. There are some lingering bits of evidence to suggest that although all capillary beds may extract gastrin equally, the renal bed may be first among equals.

Animals↗