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Biomedical subjects

P Kempf

Publications and source records attributed to P Kempf.

31 records · Page 2Linked to original sources
PubMed1977

[Preliminary results of preoperative radiotherapy in carcinoma of the rectum (author's transl)].

Preliminary results were evaluated in patients with carcinoma of the rectum of whom 33 had preoperative radiotherapy and 23 were treated by operation only. The tumour stage was T2-4 NX MO in all patients. There was no significant difference between the groups as to postoperative mortality, would healing, and postoperative admission time. However, the recurrence rate was significantly lower in pre-irradiated patients than in those treated by operation only. The combination of radiotherapy and radical operation appears to be a possible means of significantly improving the survival rate of patients with carcinoma of the rectum.

Adult↗
PubMed1977

[Surgical therapy of carcinoma of the colon and rectum (author's transl)].

Carcinoma of the colon and rectum have a much better prognosis and a higher 5 years survival rate than other tumors of the gastro-intestinal tract. In spite of this, further improvements in therapy seem to be possible; cure rates could be improved by early diagnosis, and by a combination of 3 forms of therapy: preoperative X-ray therapy, radical surgery involving colon or rectum plus regional lymph-nodes, and adequate chemotherapy. A special problem is iso- and metachronic multiplicity. Recurrent disease may be diagnosed early enough by careful postoperative controls especially during the first postoperative year and can be managed surgically with good results.

Colonic Neoplasms↗
PubMed1976

[Reintervention in recurrent carcinoma of the large bowel (author's transl)].

Reintervention has a good change of success in recurrent of carcinoma of the sigma and colon. Early detection is essential for reintervention to be successful, and meticulous follow-up is therefore necessary in all patients operated on for tumors: follow-up examinations can best be carried out at a special tumor clinic. Since 1964,-42 patients have undergone reintervention for recurrences. In 50% of them the condition was found to be inoperable. On the other hand, 14 of 21 patients in whom reintervention was successful are still alive. Adjuvant therapy such as radio therapy or cytostatics is rarely administered, but should be employed more in the future.

Colon, Sigmoid↗
PubMed1976

[Multiple carcinoma in colon and rectum (author's transl)].

43 multiple carcinomas of the colon and rectum were studied. 20 of those tumours showed a simultaneous manifestation, and 23 of them a metachroneous one. The interval between primary and secondary manifestation varied from 1 to 17 years. This clearly demonstrates that even after a very long tumour-free interval a secondary manifestation of the carcinoma can still be possible. The high percentage of multiple carcinomas of the colon calls for a careful preoperative diagnosis and an extensive intraoperative exploration of the whole colon. After hospitalisation a repeated check-up (3 months) is needed in the outpatients department to detect any secondary or recurrent carcinoma at the very earliest stage. In this way we were able to find 23 metachroneous manifestations and 27 recurrent carcinomas which were still resectable. The treatment of choice for polyposis coli is total colectomy.

Colectomy↗
PubMedDate not supplied

Clinical efficacy and safety of teicoplanin in the treatment of gram-positive infections.

This study was an open efficacy and safety study of teicoplanin in hospitalized patients with gram-positive infections. 26 patients entered the study. Teicoplanin was administered by intravenous bolus injection at a dose of 200 mg or 400 mg every 24 h, and in all cases an initial loading dose of 400 mg was given. The mean duration of treatment was 9.4 days (range four to 20 days). The infections included 18 skin/soft tissue, four lower respiratory tract, two urinary tract and two joint/bone. Clinical cure and improvement occurred in 20 of the 26 patients. Only two adverse events (moderate diarrhoea and mild pain at injection site) related to teicoplanin occurred in one patient. It was concluded that teicoplanin was effective and well tolerated in the treatment of gram-positive infections.

Adult↗
PubMedDate not supplied

Meropenem monotherapy versus cefotaxime plus metronidazole combination treatment for serious intra-abdominal infections.

In an open, randomised, multicentre trial, the efficacy and tolerability of empirical meropenem monotherapy (1 g intravenously every 8 hours) and cefotaxime (2 g every 8 hours) plus metronidazole (0.5 g intravenously every 8 hours) for 5 to 10 days was compared in 94 patients with serious intra-abdominal infection who required surgery. Eighty-three patients had an evaluable clinical response. Significantly more patients in the meropenem group had a satisfactory clinical response at the end of treatment (41/43 [95.3%] vs 30/40 [75.0%]; p = 0.008). The bacteriological response was also higher in the meropenem group (31/33 vs 26/32). In the bacteriologically evaluable population, a satisfactory clinical response was observed in 31/33 of those who received meropenem compared to 24/32 of the cefotaxime/metronidazole recipients (p = 0.03). Empirical meropenem monotherapy should prove a useful alternative to the currently standard combination treatment for serious intraabdominal infections.

Adult↗