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Biomedical subjects

P Kemeter

Publications and source records attributed to P Kemeter.

At least 55 records · Page 3Linked to original sources
PubMed1983

[Morphologic, endocrine and technical factors in relation to the results of human embryo transfer to the uterus].

Out of 161 cycles in which the procedure was attempted, 20 clinical pregnancies were obtained by in vitro fertilization and embryo transplant. The authors think that among the numerous parameters that can affect the result favourably are: At the time of oocyte recovery large follicles (23 mm) following treatment with Clomid gave oocytes with pregnancy following. Medium B2 added to human serum gave high fertilization rates (80%) and cell division rates (75%) following in vitro culture. Only those embryos where cell division occurred quickly gave rise to pregnancies. As far as the transplant was concerned, the pregnancy rate rose from 12 to 30% according to whether one replaced 1 or 2 embryos in the uterus. Preliminary examination of the cervical canal indicated whether it should be dilated in cases where it was difficult to introduce the catheter. Giving valium made the uterus relax whereas adding blood serum (50 to 75%) in the transfer medium increased the viscosity of this latter. 19 of the 20 pregnancies resulted when the embryo transfer was easily accomplished.

Cell Division↗
PubMed1982

[Treatment of amenorrhea with a LH-RH-analogue as nasal spray].

29 amenorrhoic women were treated with the Buserelin nasal spray (HOE 766) developed by Hoechst A. G. in a dosis of 50 microgram daily during 2 weeks. 22 of the patients desired restoration of menstrual cycle, 7 women were wanting a child. As result of the treatment 16 women menstruated, 6 ovulated, 2 became pregnant. With Buserelin nasal spray menstruation was induced in 12 out of 16 women with amenorrhea WHO group II.

Adolescent↗
PubMed1982

Could aspiration of the Graafian follicle cause luteal phase deficiency?

Luteal phase quality was evaluated in 32 patients wih nonstimulated cycles after laparoscopic oocyte recovery for in vitro fertilization. A luteal phase deficiency occurred in two cases (6.2%), the mean duration of the luteal phase was 13.5 +/- 1.3 days in 30 patients, and two patients developed amenorrhea of 23 and 43 days respectively after laparoscopy in spite of normal progesterone values 7 and 9 days after oocyte recovery. Six embryo transfers were performed after fertilization and regular cleavage of the obtained oocytes. No pregnancy resulted from the embryo transfers, although the patients had apparently normal luteal phases. In one patient there was a transient beta-subunit human chorionic gonadotropin (beta-hCG) elevation in serum. Luteal phase deficiency should not be main cause of a nonsuccessful embryo transfer. However, a prophylactic luteal phase support after oocyte recovery and embryo transfer in nonstimulated cycles is proposed.

Chorionic Gonadotropin↗
PubMed1982

Influence of laparoscopic follicular aspiration under general anaesthesia on corpus luteum progesterone secretion in normal and clomiphene-stimulated cycles.

In 32 patients with unstimulated normal cycles and 24 with cycles stimulated with clomiphene and human chorionic gonadotrophin (hCG) all visible follicles were punctured laparoscopically under general anaesthesia for the purpose of in vitro fertilization. In unstimulated cycles the time of surgery was between 24 and 32 h after the first luteinizing hormone (LH) increase in the urine; in the cycles stimulated with hCG (5000 i.u.) laparoscopy was between 35 and 37 h after injection. Blood samples for progesterone determination were taken about 7 days later. Progesterone levels were compared with those in a control group not subjected to surgery, in which the progesterone levels were determined 7 days after the LH increase. There was no statistically significant difference in the progesterone levels in the unstimulated subjects after laparoscopy compared with those in the control subjects but progesterone levels in the stimulated subjects were significantly higher (p less than 0.01). Durations of the luteal phases showed no significant differences thus laparoscopy under general anaesthesia does not impair luteal function.

Adult↗
PubMed1982

Corneal sensitivity during the menstrual cycle.

Corneal sensitivity was determined in 5 women with regular menstrual cycles by means of a new aesthesiometer developed by Dräger. Throughout one menstrual cycle we measured corneal touch thresholds (CTT) daily and did serial determinations of urinary luteinising hormone and pregnanediol levels. CTT rose in 4 women with proved ovulation in the days before or on the day of ovulation, while corneal sensitivity remained unchanged in one anovulatory subject. We observed no changes in CTT prior to menstruation. The decrease in corneal sensitivity might be related to the preovulatory oestrogen peak.

Adult↗
PubMed1981

[Functional and hormonal differences between group I and group II amenorrhoea (WHO classification) (author's transl)].

77 amenorrhoeic women were classified as responding positively or negatively to clomiphene. The results of iterative LRH tests and studying feed-back reactions to steroid administration showed that the two collectives strictly correspond to groups I and II of the WHO classification of amenorrhoea. The LH response to the LRH test was significantly higher in group II than in group I, while there was no difference between the two groups in the FSH response. Oestradiol 17 beta was significantly higher in group II than in group I, but both groups showed a significant increase in E2 three hours after the LRH test. The possible mechanisms of LH production and pool formation, as well as FSH regulatory factors are discussed. This paper demonstrates that clomiphene appears to be ideally suited as a test substance for the classification of amenorrhoea according to its degree of severity.

Adult↗
PubMed1981

Results of laparoscopic recovery of preovulatory human oocytes from nonstimulated ovaries in an ongoing in vitro fertilization program.

The technique and results of 50 laparoscopies performed on sterility patients to obtain mature oocytes from Graafian follicles with a view to carrying out in vitro fertilization are described. In 32% of all laparoscopies and in 52% of all punctured follicles it proved possible to obtain a mature oocyte. Different diameters of puncture needles as well as different suction intensities are compared. As a result of increasing experience and improved technique, the exact time for the intervention was correctly determined in 92% of cases. The recovery rate for oocytes was also increased to 58% with respect to laparoscopies carried out.

Cell Separation↗
PubMed1981

[Technique of obtaining mature oocytes via laparoscopy for in-vitro fertilisation (author's transl)].

Technique and results of 50 laparoscopies performed on sterility patients to obtain mature oocytes from Graafian follicles to carry out in vitro fertilisation, are reported. In 32% of all laparoscopies and in 52% of all punctured follicles a mature oocyte could be obtained. Different diameters of puncture needles as well as different suction intensities are compared. It is mentioned that through increasing experience and improved technique the exact time for the intervention has been correctly determined in 92%. The recovery-rate for oocytes also could be increased to 58%. A further improvement in this important initial step to a successful in vitro fertilisation program is feasible.

Female↗
PubMed1981

[Human in vitro fertilisation and embryotransfer: first results at the 2nd department of obstetrics and gynaecology, university of vienna (author's transl)].

Methods and Results of human in vitro fertilisation at the 2nd Department of Obstetrics and Gynaecology, University of Vienna are reported. Applying preparations of media and culture techniques according to Edwards et al. no satisfactory results could be achieved: only 3 out of 11 preovulatory oocytes were fertilised, no cleavages occurred. Using modified Ham's F 10 medium according to Lopata et al. fertilisation could be observed in 60% as well as regular cleavages in 40%. 5 Embryotransfers have been performed in the 8 cell or in the 16 cell stage respectively. No implantation occurred in 4 of these, in one case evidence for a transient implantation could be proved by an increased activity of SP1 and HCG beta. In this case obviously postimplantation death occurred resulting in a bleeding 16 days after oocyte recovery. Possible reasons for failures in fertilisation and cleavage as well as possibilities for improving the rate of reimplantation are discussed.

Adult↗
PubMed1980

[Urinary catecholamine excretion in women with a normal menstrual cycle (author's transl)].

The daily excretion of epinephrine and norepinephrine was analysed throughout one menstrual cycle in 8 normal women under every day circumstances. Blood levels of LH, FSH, prolactin, oestradiol, progesterone, testosterone and cortisol were determined by RIA every other day, or daily around the time of ovulation. No characteristic cyclic variations were found in epinephrine except for a peak in the premenstrual period, whilst norepinephrine was increased during menstruation and at about the time of ovulation in all women. The cortisol patterns showed no characteristic cyclic changes. Possible correlations are discussed between cyclic catecholamine changes and the well known psychological and emotional changes corresponding with the phases of the menstrual cycle.

Catecholamines↗
PubMed1980

[The absorption of conjugated oestrogens from the irradiated and non-irradiated vagina (author's transl)].

Eighteen women received for four weeks daily applications of conjugated estrogens in ointment. Seven had had primary irradiation of carcinoma of the cervix and eleven were in the menopausal stage without irradiation. Before the first medication and 1, 2, 4, 6, 8, 12 and 24 hours afterwards the estradiol, FSH and LH levels were estimated and the mean values of the two collectives compared. Cytologic smears of the vaginal wall were taken weekly of three irradiated and seven not irradiated patients. From the results one can draw the conclusion that an absorption of the estrogens through the vaginal wall takes place leading to local as well as systemic effects of the estrogens. However in the radiated patients the absorption of estrogen and maturation of the epithelium was significantly slower than in the not-irradiated group.

Absorption↗