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Biomedical subjects

P Kaur

Publications and source records attributed to P Kaur.

At least 163 records · Page 9Linked to original sources
PubMed1978

Unsuspected gonococcal infection in female patients.

Four hundred and ten female patients attending obstetric and gynaecological outpatient departments were investigated for possible gonococcal infection. All were in their reproductive phase. Forty-two (10.2%) of them harboured Neisseria gonorrhoeae. Of the infected patients, 40.5% had no symptoms at all. Investigation was carried out using a single, endocervical specimen cultured in Chacko-Nair egg-enriched media.

Adolescent↗
PubMed1976

Salivary gland chromosomes of Lucilia cuprina (Diptera, Caliphoridae).

The salivary gland chromosome complement in Lucilia cuprina consists of five pairs of autosomes and two sex chromosomes X and Y, all with characteristic banding patterns. A standard map for the salivary gland chromosomes of this species has been prepared, and compared with the known map of Lucilia cuprina dorsalis from Australia. The differences in their banding patterns indicate the existence of different varieties within the same species.

Animals↗
PubMedDate not supplied

Design of peptides using alpha, beta-dehydro-residues: synthesis, crystal structure and molecular conformation of N-Boc-L-Val-delta Phe-delta Phe-L-Ala-OCH3.

To obtain general rules of peptide design using alpha, beta-dehydro-residues, a sequence with two consecutive delta Phe-residues, Boc-L-Val-delta Phe-delta Phe-L-Ala-OCH3, was synthesized by azlactone method in solution phase. The peptide was crystallized form its solution in an acetone/water mixture (70:30) in space group P6(1) with a = b = 14.912(3) A, c = 25.548(5) A, V = 4912.0(6) A3. The structure was determined by direct methods and refined by a full matrix least-squares procedure to an R value of 0.079 for 2891 observed [I > or = 3 delta (1)] reflections. The backbone torsion angles phi 1 = 54(1) degrees, psi 1 = 129(1) degrees, omega 1 = -177(1) degrees, phi 2 = 57(1) degrees, psi 2 = 15(1) degrees, omega 2 = -170(1) degrees, phi 3 = 80(1) degrees, psi 3 = 7(2) degrees, omega 3 = -177(1) degrees, phi 4 = -108(1) degrees and psi T4 = -34(1) degrees suggest that the peptide adopts a folded conformation with two overlapping beta-turns of types II and III'. These turns are stabilized by two intramolecular hydrogen bonds between the CO of the Boc group and the NH of delta Phe3 and the CO of Val1 and the NH of Ala4. The torsion angles of delta Phe2 and delta Phe3 side chains are similar and indicate that the two delta Phe residues are essentially planar. The folded molecules from head-to-tail intermolecular hydrogen bonds giving rise to continuous helical columns which run parallel to the c-axis. This structure established the formation of two beta-turns of types II and III' respectively for sequences containing two consecutive delta Phe residues at (i + 2) and (i + 3) positions with a branched beta-carbon residue at one end of the tetrapeptide.

Crystallization↗
PubMedDate not supplied

Comparison of single-, double- or triple-exposure protocols for the rodent bone marrow/peripheral blood micronucleus assay using 4-aminobiphenyl and treosulphan.

Two human carcinogens, 4-aminobiphenyl (4AB) and treosulphan (Treo), were tested in male B6C3F1 mice for the induction of micronuclei in bone marrow and peripheral blood cells by 1-, 2- and 3-exposure protocols. Both compounds tested positive. The magnitude of response with respect to the incidence of micronucleated polychromatic erythrocytes by 2- and 3-exposure protocols was considerably higher than by the single-exposure protocol. The peripheral blood results for Treo were as typically seen with a 24-h delay when compared to the bone marrow. The peripheral blood results for 4AB, however, differed from those expected. The incidence of MN-PCE in peripheral blood of animals exposed to 4AB was significantly greater than seen in the bone marrow in 2- and 3-exposure protocols. There was also an increase in the % PCE at the 60 mg/kg dose level as a function of time. Based on these studies, it is concluded that a step-wise scoring scheme may be the best protocol for rodent micronucleus assay, involving a 3-exposure protocol with single sampling of bone marrow (24 h after the last treatment) and two samplings of peripheral blood (24 h and 48 h after the first treatment). This approach is cost-effective, it limits the number of animals required and provides maximum sensitivity.

Aminobiphenyl Compounds↗
PubMedDate not supplied

A prospective study of sensitivity and specificity of adenosine deaminase estimation in the diagnosis of tuberculosis pleural effusion.

We prospectively evaluated the usefulness of adenosine deaminase [ADA] estimation in the diagnosis of tuberculosis [TB] pleural effusion. Seventy five subjects with pleural effusion were studied. Forty eight of them had TB pleural effusion [M:F: 37:11; mean age 33 +/- 14.4 years range 17-76] and the remaining 27 had pleural effusion due to causes other than TB [non-TB group] [M:F: 19:8; mean age 47.3 +/- 16.5 years; range 17-75]. Pleural fluid [PF] ADA levels were significantly higher in TB (n=48; mean 95.8 +/- 57.5 IU/L) compared with non-TB group (n=27; mean 30.7 +/- 27.2 IU/L) [p<0.001]. Serum ADA [S-ADA] levels were also significantly higher in TB (n=45; mean 39.6 +/- 18.3 IU/L) compared with non-TB group (n=26; mean 18.0 +/- 13.7 IU/L) [p<0.001]. PF-ADA levels were higher compared to S-SDA in TB (p <0.001) and non-TB groups [p<0.01]. Using a cut off of 35 IU/L, the sensitivity and specificity of PF-ADA in the diagnosis of TB was computed to be 83.3% and 66.6% respectively. At a cut-off level of 100 IU/L, PF-ADA was found to have a sensitivity 40% and specificity 100%. From this study it is concluded that, using 100 IU/L as the cut-off, it is possible to avoid pleural biopsy to ascertain the diagnosis of TB in as much as 40% of the patients.

Adenosine Deaminase↗
PubMedDate not supplied

An epidemiological study of goitre in two rural communities of Varanasi.

A cross sectional study was conducted in two rural communities of Varanasi during the period from January to December 1978 to find out the problem of endemic goitre. The overall prevalence of goitre was as high as 28.44% with 9.45% of adolescent (13-18 years) population having grade I enlargement. The highest prevalence was observed in 7-12 years of age group, the females being consistently more affected in all the age groups. The prevalence of goitre and iodine level of drinking water found to have an inverse relationship.

Adolescent↗
PubMedDate not supplied

Bedside urinalysis in untreated leprosy patients.

The study included 53 patients of untreated leprosy attending University Hospital, Banaras Hindu University during study period of 1 1/2 years. The various types of leprosy included 9,14,16 and 14 cases of tuberculoid, borderline, lepromatous and leprosy with type II reaction respectively. Majority of the patients were below the age of 49 years with male preponderance. 66.04% of patients came from the rural area. Painful micturation (dysuria) (13.20%) was the commonest urinary complaint recorded on enquiry. Specific gravity of urine did not show any change. Abnormal proteinuria was noted in 16.98%, 11.32%, 7.54% and 3.77% of patients of leprosy with reaction, lepromatous, borderline and tuberculoid group respectively. Significant haematuria, pyuria and epithelial cells were noted in all the groups. Haematuria was recorded in focal segmental Glomerulonephritis (GN), mesangioproliferative and diffuse endocapillary Glomerulonephritis (GN) incidence of which was 7.89%, 7.89% and 5.26% respectively in the biopsy tissue. Significant pyuria was noticed in all the groups except minimal change GN.

Adult↗
PubMedDate not supplied

Deformities in leprosy patients attending urban leprosy clinic at Varanasi.

Analysis of records of urban leprosy clinic of the University Hospital, Varanasi for deformities was done for the years 1979 to 83. Gross deformity rate was 3.73 percent only. The majority of cases of deformity were in borderline type of leprosy. The commonest deformity was claw hand. It is discussed that dapsone treatment does not increase the chance of deformity. The rate, however, increased with age.

Adolescent↗