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Biomedical subjects

P Karlberg

Publications and source records attributed to P Karlberg.

At least 37 records · Page 2Linked to original sources

Long-term effect of previous swimtraining in girls. A 10-year follow-up of the "girl swimmers".

Thirty girls, studied in 1961 after 2.5 years of intensive swimtraining, were the subject of a follow-up for ten years. When last examined, seven and ten years after the original study, all the girls had given up swimtraining. The increased values for vital capacity observed in 1961 remained unchanged, but residual volume, functional residual capacity and total lung capacity showed small increases even after corrections for body growth. Such increases are, however, normal in these years. Heart volume which was high originally, was found to be lower ten years later, although mean values were still higher than normal. The decreases seen from 1961 to 1971 could mainly be ascirbed to a decrease in the subjects with the larges hearts originally. Both total hemoglobin and blood volume decreased to normal values in relation to body size. Maximal oxygen uptake, though, fell from 2.80 l/min (51. 4 ml/kg X min) to 2.18 l/min (36.4 ml/kg X min) ten years later. It is suggested that the functional capacity of the cardiovascular system declined more markedly than its dimensions.

Adolescent↗

Clinical application of evoked electroencephalographic responses in newborn infants. I: Perinatal asphyxia.

Evoked electroencephalographic responses are useful for the study of cerebral maturation in full-term and pre-term newborn infants. In an attempt to achieve wider clinical application, 57 newborn infants with differing degrees of perinatal asphyxia were examined. Altogether 154 examinations were performed. In all of them photostimulation was used, and in 72 investigations somatosensory evoked responses were also recorded. The following results were obtained: (1) Visual evoked responses were affected in 85 per cent of the cases. Somatosensory evoked responses were affected less often - in 65 per cent of the newborn babies examined. The incidence and degree of deviations were related to the degree of asphyxia. (2) The most characteristic features of the evoked responses in asphyxiated infants were abnormal response patterns, increase of latency and poor photic driving. (3) On the basis of all alterations observed, a scoring system was developed which enabled quantitative evaluation. The evoked response risk-score correlated well with the degree of asphyxia. (4) Repeated observations were important: a permanently high risk-score at repeated investigations was a serious prognostic sign.

Asphyxia Neonatorum↗

I. physical growth from birth to 16 years and longitudinal outcome of the study during the same age period.

Physical growth of 212 randomly selected Swedish urban children has been investigated from birth to sixteen years as part of a prospective longitudinal study of growth and development. Twenty body measurements have been taken at specified ages. In all, about 66,000 values of measurement have been recorded. At sixteen years 179 (84.4%) ofthe original children were still regularly being followed. Thirty-three (15.6%) of the 212 children left the study at various ages. A comparison between the children who left the study and those remaining did not show any significant differences in physical growth. All recorded data have been scrutinized in order to detect errors of measurement or administrative errors. Such values have been corrected or excluded. The editorial procedures also included the adjustment of each measurement to exact target age, interpolation of missing examinations and exclusion of children with an aberrant growth pattern. When comparing the present study with older Swedish investigations a secular trend was established, while there was good agreement with other contemporary Swedish investigations. Growth charts of distance values of various body measurements are presented. In the charts standard deviation lines (+/- 1, 2, 3 SD) and mean values are plotted. A logarithmic time scale (logarithmic conceptional age) has been used for both practical and theoretical reasons. When evaluating individual values in comparison with reference values standard deviations should be used rather than centiles. With this approach even grossly deviating values can be evaluated. Longitudinal follow-up of individual children and comparison of children of different ages will also be facilitated by this approach.

Adolescent↗

IV. skeletal development from birth to 7 years.

The skeletal development of 212 randomly selected Swedish urban children has been investigated as part of a prospective longitudinal study of growth and development. Radiograms of the hand and wrist were taken at specified ages. Up to the age of seven years 2.191 radiograms were assessed. When comparing the timing of the first ossification of the various bones in the present study and an older Swedish investigation a secular trend was found. In contrast to a North-American growth study, there was a striking similarity of the pattern of the first ossification in the two Swedish investigations for both sexes separately. However, the relative sex differences of the ossification were quite similar in the North-American growth study and the present investigation. In comparison with British children the skeletal development of Swedish children was advanced at all ages, the advancement being greater for epiphyseal bones than for carpal bones.

Age Determination by Skeleton↗

V. a new method for the assessment of skeletal maturity- the mat- method (mean appearance time of bone stages).

By means of probit analysis of the age at the appearance of the various bone stages according to Tanner-Whitehouse and using a logarithmic time concept (logarithmic conceptional age), a new approach to the evaluation of skeletal maturity has been elaborated. The maturity score of each bone stage corresponds to th4 mean maturity level of the observation of being within each stage. The individual maturity level is calculated by averaging the maturity scores of the stages of the various bones and is then evaluated is standard deviation scores by comparing with teh Gaussian fitted distribution of averages maturity scores of the age of the child examined. Special conditions apply for the scoring of a first and a last bone stage in a sequence, which will introduce less bias in the estimation of individual skeletal maturity with the MAT-method than with the TW-method. Ossification during early infancy can be evaluated and sequence polymorphism be detected by using the bone stage chart of the MAT-method.

Age Determination by Skeleton↗

VII. graphic analysis of biological maturation by means of maturograms.

The attainment of various maturity criteria has been analyzed by probit analysis using a logarithmic time concept (logarithmic conceptional age). The resulting probit lines have been plotted in charts-maturograms -using the x-axis as an age-scale and the y-axis as a marker of standard deviations scores. The slope of the probit lines is in such a direction that early occurrences are assigned positive SD-scores and late ones negative scores. The maturity criteria can be divided into two catergories- sequential (e.g. number of erupted teeth) or non-sequential (e.g. the menarche). When examined a child is observed to be within a certain stage of maturity. The observation can be evaluated with a cross-sectional or a longitudinal approach. The latter requires repeated examinations. The evaluation will result in a relative scoring (SD-scores) of the observations, i.e. a relative maturity level is calculated. The practical procedure has been exemplified for pubertal and dental development. Two sets of charts-pubertograms-have been constructed for the assessment of pubertal development in each sex. For dental development there are also two sets of sex-specific charts -dentograms- one for the deciduousdentition and one for the permanent dentition. Individual patterns of maturation can be analyzed by plotting the estimated SD-scores of the various maturograms. Individual variations in the trends of the estimated SD-scores may be an indication of different velocities of maturation.

Adolescent↗