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Biomedical subjects

P Kar

Publications and source records attributed to P Kar.

At least 55 records · Page 3Linked to original sources
PubMed1997

Comparative evaluation of cell proliferative indices and epidermal growth factor receptor expression in gastric carcinoma.

A total of 62 patients of gastric carcinoma were studied to find a correlation between newer prognostic indicators like cell proliferative indices including Nucleolar Organizer regions (AgNORs), Ki 67 Labelling Index and Epidermal Growth Factor Receptor (EGFR) expression with the various, histopathological criteria and compared with 30 controls of non neoplastic gastric diseases. EGFR expression was positive in 48(77.4%) cases. The Ki 67 labelling indices ranged from 0 to 50% with a mean of 21.35 +/- 17.88% among the cases. AgNOR counts ranged from 1.64 to 4.49 with a mean of 3.41 +/- 0.81 among the cases. Positive EGFR expression correlated strongly with differentiation of the tumour, poorly differentiated tumours showing a higher positivity. EGFR positivity also showed good correlation with metastasis as well as with the invasiveness of the tumour. Ki 67 labelling indices correlated significantly with metastatic status, microscopic types and degree of differentiation of the tumour. A strong correlation was observed between AgNOR counts and metastasis as well as the microscopic type of the tumour. EGFR expression correlated strongly with Ki 67 scores and weakly with AgNOR counts among the patients of gastric carcinoma.

Biomarkers, Tumor↗
PubMed1996

A prospective study of delta infection in fulminant hepatic failure.

Thirty one patients of HBV related Fulminant Hepatic Failure (FHF) were studied for the presence of delta infection and subsequently the clinical features, course and outcome of the delta infected cases was compared with those of delta uninfected cases. Out of 31 patients studied, 11 patients (35.8%) were reactive for anti-delta antibodies. There was no significant difference in age in delta reactive and non-reactive group. Hepatic encephalopathy was seen in all of the patients. The mean SGOT and SGPT were 378 +/- 88.74 U and 454 +/- 70.44 U respectively in anti-delta reactive group as compared to 239 +/- 74.94 U and 274.1 +/- 100.34 U respectively in anti-delta non reactive group (p < 0.05). During follow up, 10/11 patients (91%) died in anti-delta reactive group as compared to 13/20 patients (65%) in anti-delta non reactive group. So this study suggests that delta virus infection is quite common in India and it lead to excerbation of illness and carries a relatively poor prognosis for FHF.

Adult↗
PubMed1993

Delta virus infection in cirrhotics in a north Indian hospital.

Forty patients of HBV related cirrhosis of the liver were studied for the presence of delta infection and subsequently the clinical features, course and outcome of these delta infected cases was compared with those of delta uninfected cases. Out of 40 patients studied, only four patients (10%) were reactive for anti-delta antibodies. The incidence of delta infection was common in the younger age group (31.25 +/- 4.78 years) as compared to the older age group (48 +/- 7.25 years) at p < 0.001. Hepatic Encephalopathy was seen in only 13.88% of delta negative patients as compared to 75% of delta infected patients (p < 0.05). During follow up period of 1 year, 75% of patients died in the delta virus infected group as compared to 22.22% in the delta negative group. The mortality was significantly higher in Child's class C (P < 0.01). So delta virus infection is associated with a more severe course of illness and a poorer prognosis in HBV related cirrhotics.

Adolescent↗