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Biomedical subjects

P Kaeser

Publications and source records attributed to P Kaeser.

At least 19 recordsLinked to original sources
PubMed2005

Influence of change in body position on choroidal blood flow in normal subjects.

AIM: To compare subfoveal choroidal blood flow (ChBF) in sitting and supine positions in normal volunteers. METHODS: ChBF was measured with laser Doppler flowmetry in 22 healthy volunteers of mean (SD) age 24 (5) years. Six independent measurements of ChBF were obtained in one randomly selected eye of each subject while seated. The subjects then assumed a supine position for 30 minutes and a new series of six measurements was obtained. The mean values of the two series were calculated. Systemic brachial artery blood pressure and intraocular pressure were measured in the sitting and supine positions. Ocular perfusion pressure (OPP) was calculated based on formulae derived from ophthalmodynamometric studies. The influence of changing OPP during change in body posture on the change in ChBF was assessed by linear regression analysis. RESULTS: ChBF decreased by 6.6% (p = 0.0017) in the supine position. The estimated ophthalmic blood pressure in the supine position was adjusted to obtain a result of no change in OPP for no change in ChBF, yielding a mean decrease in the estimate of OPP of 6.7% (p = 0.0002). The necessary adjustment for the estimate of OPP in the supine position suggested a marked buffering of the change in perfusion pressure by the carotid system. The relative decrease in OPP correlated significantly with the relative decrease in ChBF (R(2) = 0.20; p = 0.036) with a slope for the regression line of 1.04. CONCLUSIONS: The comparable degree of change in ChBF and OPP and the linear relationship between the two parameters suggest a passive response of the choroidal circulation to a change in posture. In contrast, the carotid system seems to control the gradient in perfusion pressure closely between the heart and its branches.

Adolescent↗
PubMed2003

[Hyponatremia: an unusual case report].

Hyponatremia is a frequent finding and asks for a rapid diagnostic evaluation. We report a case of recurrent hyponatremia secondary to an adrenal insufficiency of medicamentous and tuberculous origin. This case illustrates the importance of a rapid etiologic diagnosis of hyponatremia and allows us to review adrenal insufficiency of tuberculous origin. It also stresses the danger of potential drug interactions in case of corticosteroid substitution.

Addison Disease↗
PubMed2001

Ticlopidine-induced interstitial pulmonary disease: a case report.

We report a case of interstitial pulmonary disease that occurred together with lymphocytic colitis during treatment with ticlopidine. The drug was prescribed for transient ischemic cerebrovascular accidents. Ticlopidine treatment was stopped, and a prolonged course of prednisone was necessary to treat the pulmonary and intestinal symptoms. So far, few cases of pulmonary side effects caused by ticlopidine have been reported. This case is unique in that interstitial lung disease evolved in parallel with colitis and caused severe hypoxemia. Special care should be taken when pulmonary symptoms appear in association with ticlopidine treatment.

Aged↗
PubMed1999

[Endocarditis manifesting as a spondylodiscitis and psoas abscess].

The revealing of a bacterial endocarditis by a spondylodiscitis is relatively rare. Only 80 cases have been reported ever since De Sèze's and his team's first publication in 1965. We report the case of a 59 year old women, hospitalized for a meningitis who presents signs of a spondylodiscitis and psoas abscess revealing an endocarditis. This case shows that one always have to search for an endocarditis when dealing with a spondylodiscitis. A thorough examination including a cardiac ultrasound is mandatory and a six weeks follow-up is necessary, since the prognosis depend mainly on the valvular disease.

Discitis↗
PubMed1999

[Cardiac perforation by a gastric ulcer: an unusual cause of death, after an esophageal and gastric resection of an epidermoid esophageal carcinoma].

We report here the case of a 55 year old female that underwent surgery for a well differentiated squamous cell carcinoma of the esophagus (middle third). Four months after surgery, she complains of neck pain, for which she is prescribed non steroidal antiinflammatory drugs (NSAID). A CT-scan and a Barium swallow are then normal. After three weeks of treatment, the patient is admitted on emergency to the Intensive Care Unit for a resuscitation hematemesis and atrial fibrillation with a fast ventricular response. The symptoms are stabilized after the transfusion of a few packed red blood cells. A few hours later, however, a massive hematemesis recurs and the patient dies despite intense resuscitation measures. Autopsy reveals three gastric ulcers, one of which had perforated through the cardiac left ventricular wall.

Carcinoma, Squamous Cell↗
PubMed1995

[Horton's disease: ophthalmological and neurological complication].

We report the case of a 74-year-old women admitted to the hospital because of rapidly developing diplopia. The admission anamnesis revealed fronto-temporal headaches and pain in the maxilla for three days. A cerebral cT scan was normal, and a corticosteroid therapy was initiated. Diagnosis of Horton's syndrome was confirmed by the good response to treatment and by biopsy of the temporal artery. Different ocular and neurologic complications of Horton's disease, their clinical appearances and therapeutic measures are discussed by the authors.

Acute Disease↗
PubMed1995

[Anaphylactic shock].

Anaphylactic shock is an unexpected, sudden and sometimes deadly event that attacks the patient in 75% of the cases without pre-existent history of allergy. In general, drugs, hymenopteric poisons and nutrients (according to the recent concept) are responsible. Beside the classical IgE-mediated anaphylactic shock there exists another anaphylactic shock, identical in its clinical picture and treatment but not in the mechanism of development. Epinephrine is the only effective drug in case of respiratory (bronchial asthma, laryngeal edema) or cardiovascular (hypotension, arrhythmias, hypovolemic shock) manifestation. It has to be administered as rapidly as possible.

Anaphylaxis↗