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Biomedical subjects

P K Sharma

Publications and source records attributed to P K Sharma.

At least 109 records · Page 6Linked to original sources
PubMed1988

Intracoronary versus intravenous streptokinase in acute myocardial infarction.

To assess the relative efficacy of coronary thrombolysis using intracoronary versus intravenous streptokinase, 32 patients with acute myocardial infarction were randomly assigned to receive intracoronary (n = 17) and intravenous streptokinase (n = 15). All patients underwent selective coronary arteriography before and after administration of streptokinase by either route within 4 hours of the onset of symptoms. Intravenous streptokinase was given as 750,000 units over 30 minutes, while a mean dose of 180,000 units was required for thrombolysis in the group having intracoronary delivery. Recanalization occurred in 71.4% (10 of 14) of patients receiving streptokinase, by the intracoronary group in contrast to only 25% of patients (3 of 12) who received the drug intravenously (P less than 0.05). Spontaneous thrombolysis was seen in 17.6% and 20% of the patients in the groups having intracoronary and intravenous delivery, respectively. Bleeding complications were few in both groups. Thus, when baseline coronary arteriography is performed, recanalization with intracoronary streptokinase is more effective in the treatment of acute myocardial infarction than intravenous streptokinase.

Adult↗
PubMed1988

Variations in the shape of the superior orbital fissure.

This paper deals with the variations in the shapes of superior orbital fissures in 214 skulls of the Anthropology Museum of the Anatomy Department of GSVM Medical College, Kanpur. 9 types of the shapes of the superior orbital fissure have been found in the present study.

Cephalometry↗
PubMed1987

Radioactive uranium in various Indian tobaccos and consumable products (snuff, chutta, bidi and cigarette).

Tobacco is chewed in the form of snuff and thus its radioactivity--if there is any--goes directly into the body. Besides normal smoking, tobacco is also smoked in reverse manner in the form of "chutta", an indigenously prepared cigar made from the home grown plants of Nicotinia tobacum in South East coastal towns and villages in India. The burnt residue and the radioactive element--if there is any--in the case of chutta smoking will also go directly in the body causing hazardous effects. Uranium traces were determined in commercially available samples of snuff, chutta, bidi and cigarette tobacco using radiation damage etch technique. The analysis showed that uranium levels varied from 7.4 to 19.1 ppm in snuff, 0.16 to 0.37 ppm in chutta, 0.13 to 0.23 in bidi and 0.037 to 0.12 ppm in cigarette tobacco.

Humans↗
PubMed1986

Catalytic properties of testicular hyaluronidase after gamma-irradiation.

The effect of gamma-irradiation on ovine testicular hyaluronidase was studied in aqueous solution. Following irradiation, hyaluronidase is inhibited, and the kinetics of inhibition follow a pattern in which Km and Vmax decline as radiation dose is increased. It was indicated that the binding affinity of the residual activity of hyaluronidase with substrate is enhanced and depends upon radiation damage. Effects of various agents such as pH, salts, PCMB and glutathione on irradiated hyaluronidase have been compared with non-irradiated enzyme. The irradiated hyaluronidase was more sensitive to inhibition by CuSO4 than the non-irradiated enzyme. The residual activity after irradiation is less refractory to FeCl3 inhibition and less sensitive to NaCl stimulation compared to non-irradiated hyaluronidase. pH response curves of ovine testicular hyaluronidase show two maxima which become more evident after irradiation.

Animals↗
PubMed1986

Postoperative wound infection in a pediatric surgical service.

Seventy-two out of 1,325 consecutive pediatric patients (5.43%) developed an operative wound infection in a general pediatric surgery unit. The wound infection rate was observed to be highest in neonates (13.75%) as compared with the children over 5 years of age (2.93%). The increased susceptibility of newborns to wound infection was found to be statistically significant. Patients operated for gastrointestinal problems and solid abdominal neoplasms had the highest wound infection rate.

Adolescent↗
PubMed1986

Emissary occipital foramen.

214 skulls were studied for the present study. A small foramen in the squamous part of the occipital bone just behind foramen magnum was noticed for the passage of emissary vein in one skull only, probably connecting occipital sinus with suboccipital venous plexus.

Cerebral Veins↗