[Diagnosis of ascites--malignant or benign etiology?].
Explore the source record for details and available documents.
Ascites↗
Biomedical subjects
P Jorpes
Publications and source records attributed to P Jorpes.
Measurement of fibronectin concentration in benign and malignant ascites.
Fifty-eight consecutive patients who were admitted to two departments of general surgery with ascites of unknown origin were investigated by measurement of ascitic fluid fibronectin concentration in a prospective study. A fibronectin concentration of 100 ml/l or more was chosen as indicative of malignant disease. In 40 patients with malignant disease, the median fibronectin concentration was 160 mg/l (interquartile range 120-270, range 20-560). In 18 patients with ascites from benign disease the corresponding figures were 40 mg/l (30-70, 20-90) (p less than 0.01). The diagnostic specificity (predictive value of a positive test) was 1.00 (34/34) (95% confidence interval 0.90 to 1.00), while the diagnostic sensitivity (predictive value of a negative test) was 0.75 (18/24) (95% CI 0.53 to 0.90). In this series an ascitic fluid fibronectin concentration of 100 mg/l or more indicated malignant disease, but a lower value did not exclude it. The test should be investigated in combination with another test with high diagnostic sensitivity to optimise its diagnostic value.
Adult↗
[The validity of arterial gas analyses--storage temperature has negligible effect].
Explore the source record for details and available documents.
Blood Gas Analysis↗
[Content of fibronectin in ascites--a method for differentiation of malignant and benign disease].
Explore the source record for details and available documents.
Adult↗
Patient with acute B-cell leukemia of Burkitt's type (L3) and marker chromosomes including an (8;14) translocation.
A 20-year-old man with acute B-cell leukemia of Burkitt's type (L3) presenting unusual début symptoms with jaw involvement is reported. The leukemic cells revealed chromosomal abnormalities including four marker chromosomes [1q+, 6q-, t(8;14)].
Adult↗
Serum phenytoin, phenobarbital, carbamazepine, albumin; and plasma estradiol, progesterone concentrations during the menstrual cycle in women with epilepsy.
Six menstrual cycles and three 1-month periods were studied in seven patients with epilepsy. The patients all had had anti-epileptic treatment for a long time. In each case, the dosages had been costant for at least 1 month prior to the start of the investigation. Blood samples were taken every second day. Phenytoin, phenobarbital, carbamazepine, estradiol and pregesterone were analyzed. The serum levels of the anti-epileptic drugs were correlated to the plasma hormone concentrations. No correlations were obtained between the plasma hormone concentrations and the serum levels of the anti-epileptic drugs. There is, therefore, no evidence that the relationship between the seizure frequency and plasma hormone concentrations, shown in a previous study (Bäckström 1976)) was related to a change in serum levels of the anti-epileptic drugs.
Adult↗