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Biomedical subjects

P Jeffery

Publications and source records attributed to P Jeffery.

29 records · Page 2Linked to original sources
PubMed1978

Skin necrosis after warfarin therapy.

A rare but potentially lethal complication of coumarin and its congeners is skin necrosis. A case of skin necrosis due to warfarin is reported and the literature is reviewed. It is suggested that if necrosis develops, the coumarin therapy should be terminated, and the patient should immediately be heparinized. Heparin, which never causes necrosis, can be used freely if further anticoagulation therapy is required, and may well prevent necrosis due to the thrombotic process.

Adolescent↗
PubMed1977

Pregnancy in diabetic women.

Pregnancy in 207 diabetic women managed at a diabetic antenatal unit over a six-year period (1970 to 1976) resulted in a perinatal mortality of 16 (7-8%). One hundred and fifty-nine women (70%) were receiving insulin before pregnancy and 20% had evidence of diabetic microangiopathy. Still birth was twice as frequent as neonatal death, and severe respiratory distress syndrome was uncommon, resulting in only one death. Bad control of diabetes was associated with a poor prognosis. This was contributed to be lack of cooperation, anxiety and poor knowledge of diabetes. The accurate assessment of gestation and maturity, the monitoring of fetal-placental function, careful blood glucose level control, and an understanding of neonatal physiology have contributed to a reduction in fetal mortality. Close cooperation between an obstetrician, physician and neonatal pediatrician experienced in the problems encountered in the management of pregnant diabetic women is essential if the best results are to be obtained.

Blood Glucose↗
PubMed1976

Location of stretch receptors in the trachea and bronchi of the dog.

1. Using single fibre vagal afferent recording techniques, we have investigated the longitudinal and circumferential location of slowly adapting stretch receptors in a functionally isolated, in situ segment of the trachea in dogs. 2. We have also studied the depth of these receptors within the airway wall and their response to reflex and drug induced contraction of the airway smooth muscle. 3. Thirty-four per cent of the receptors studied were in the extrathoracic trachea; calculations indicate that about 17-1% of all airway stretch receptors lie outside the thorax. 4. All the receptors were located in the membranous posterior wall of the trachea, and those tested responded more to transverse than to longitudinal stretching of the wall. 5. Receptors in the extrathoracic trachea continued to function after the regional mucosa had been widely resected; subsequent removal of histolocially proven smooth muscle tissue caused the abrupt cessation of receptor discharge. 6. Contraction of airway smooth muscle brought about an increase in receptor discharge frequency. 7. Similar results were found for a smaller number of stretch receptors located in the mainstem and lobar bronchi. 8. These findings procided evidence that stretch receptors are anatomically located within the smooth muscle layer of the airways and are functionally aranged in series with the muscle fibres.

Action Potentials↗
PubMed1975

Neontal hypoglycaemia in infants of insulin-dependent diabetic mothers.

Neonatal hypoglycaemia (blood glucose smaller than 20 mg/100 ml) occurred in the first 6 hours of life in 25 of 34 infants born to diabetic mothers receiving insulin. Despite severe hypoglycaemia (blood glucose smaller than 10 mg/100 ml) in 17, clinical features of hypoglycaemia were absent in all but 2. Hypoglycaemia was not related either to the level of plasma insulin in cord blood, determined as nonextracted immunoreactive insulin, or to the degree of control of maternal blood glucose during pregnancy. The frequent occurrence of severe neonatal hypoglycaemia in the infants born to diabetic mothers receiving insulin appears to be due rather to failure to maintain basal glucose homoeostasis after birth than to hyperinsulinism.

Adult↗
PubMedDate not supplied

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Attitude to Health↗
PubMedDate not supplied

The assessment of the post-thrombotic limb by foot volumetry and pedal venous pressure.

Various tests, such as foot volumetry, static and ambulatory venous pressure measurements, Doppler flow recordings and calf plethysmography, have recently been developed to aid and to attempt to quantify venous insufficiency. This paper describes a simple device for measuring foot volume changes during the prescribed exercise. The foot is placed in a water-bath and the change in foot volume is recorded by a strain-gauge pressure transducer. The transducer responds to the head of water change, which, in turn, is directly proportional to the volume change. Also described is a simple device for the measurement of pedal venous pressure using a standard, commercially available transducer. The methodology of the tests is discussed, together with sample results.

Foot↗