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Biomedical subjects

P Jeandel

Publications and source records attributed to P Jeandel.

At least 37 records · Page 2Linked to original sources
PubMed1993

[Cytological study of deep lung in spondyloarthritis. Apropos of 34 cases].

Bronchoalveolar lavage (BAL) was performed in 34 consecutive patients with spondyloarthropathy (SA) compared with 9 controls. Lymphocytic alveolitis was found in the SA group with decrease in the ratio of the CD4/CD8 subsets in both lung and blood. Neutrophilic alveolitis was also found in 5 patients with SA of long duration. As with other inflammatory diseases, it seems that a subclinical alveolitis is present in SA patients.

Adult↗
PubMed1992

[Value and limits of tomodensitometry applied to the diagnosis of sacroiliitis in young adults: study of 200 cases].

Diagnosis of sacroiliitis may be difficult to establish in patients under 25 years of age since growth is not yet completed and joint damage is often still minor. A prospective study of 200 subjects with a median age of 22 years was carried out to compare the value of CT scan and conventional radiology. The study population included 32 healthy subjects and 168 consecutive patients with presumptive spondylarthropathy including 36 with bilateral sacroiliitis and 8 with unilateral sacroiliitis. Conventional roentgenograms and CT scans were performed in every patient. Blind reading of roentgenograms and CT scans was carried out by two pairs of observers with differing experience. CT scan provided no additional information when reading was done by experienced observers: rates of mistaken and doubtful results were similar with both investigations (10%); specificity of both tests was comparable (90%) but sensitivity was significantly greater for CT scan (91.2%) than for conventional roentgenograms (71.6%), reflecting improved detection of roentgenographically occult sacroiliitis. Less experienced observers obtained better results with CT scans, illustrating the ease of interpretation of CT scan images. Analysis of false-positive CT scans revealed that normal variations and, above all, features due to as yet uncompleted growth were the main sources of mistakes. These mistakes cancelled the advantage of increased sensitivity of CT scan studies and explained why CT scan failed to improve diagnosis.

Adult↗
PubMed1992

[Post-traumatic osteolysis of the distal extremity of the clavicle. Anatomopathological study of 2 cases].

Two patients with post-traumatic osteolysis of the distal end of the clavicle undergoing surgery 5 months and 22 months respectively after the initial trauma were evaluated histopathologically. The lysed zone was replaced by tissue of fibrous appearance, with little blood supply and non-inflammatory, the presence of which could be suspected by magnetic resonance. The synovial membrane, non-inflammatory but hypervascularised, participated in the process but did not appear to be directly responsible for the osteolysis. The osseous tissue of the patient, operated upon early, showed signs of osteoclastic resorption but there was neither stasis, vasodilatation nor signs of osteogenesis. These various findings suggest that post-traumatic osteolysis of the distal end of the clavicle does not result from local ischemic events. These appearances seem identical to those described in multifocal primary osteolysis, the cause of which also remains unknown.

Adult↗
PubMed1991

[Post-traumatic osteolysis of the distal end of the clavicle. Contribution of MRI].

The authors describe a case of post-traumatic osteolysis of the clavicle. The clinical and roentgenographic aspects are well known. But regarding the lytic X ray aspect, another diagnosis, particularly a tumor may be evoked. Scintigraphy and computed tomograms can take a part in the diagnosis. But scanograms are uneasy to do in this region. The MRI allows to delimit the lesion, and the hypointense signal in T1 and T2 weighted sequences directs to a fibrosis in the area between the end of the clavicle and the acromion. In this case report, the relation between the MRI findings and the pathological aspects was good.

Adult↗
PubMed1990

[Rheumatological aspects of infection with human immunodeficiency virus (HIV)].

Since 1987, some works have been devoted to rheumatological manifestations appearing during the course of the HIV infection. If neurotropism of this retrovirus explains some misleading pseudo radicular aspects of the disease, sometimes revealing, inflammatory neuro-arthropathies are still under discussion. In Tropical Africa, increase of reactive arthritis of REITER's type seems to be correlated with the present epidemic outbreak. It is also admitted that HIV has a direct arthritic effect. These two facts lead to elaborate several pathogenic hypothesis concerning rheumatoid arthritis and spondylarthritis. On the other side, some systemic diseases may appear or be simulated at the occasion of the HIV infection, in particular, some lupoid manifestations. During AIDS, lymphocytic depletion may be at the origin of series of biological abnormalities that have to be known in order to mislead diagnosis.

Acquired Immunodeficiency Syndrome↗
PubMed1989

[Treatment of reflex algoneurodystrophies by sympathetic blockade with guanethidine].

Reflex sympathetic dystrophy (RSD) can be treated by regional sympathetic blockade with guanethidine. This method was used systematically in 25 patients with post-traumatic RSD of the upper (n = 8) or lower limb (n = 17). Sixty three blocks were performed, each patient receiving 1 to 4 blocks. The results were appreciated by the effects after one month on pain, mobility and trophic changes. They were excellent in 7 cases, good in 4 cases and poor in 7 cases. The results were better in moderate RSD without psychiatric overlay. Thirteen patients were cured after 3 months. Pain decreased significantly 2 days after injection in 28 of the 63 blocks. The effects on mobility and trophic changes always occurred after the analgesic effect. No side effects were observed with the exception of one patient who had a convulsion 2 hours after the injection. These results show that regional sympathetic blockage with guanethidine is useful for the treatment of RSD, especially in its moderate stages. In view of the negligible risks and its efficacy, the authors consider it to be the first line treatment of moderate RSD.

Adult↗