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Biomedical subjects

P Jauhar

Publications and source records attributed to P Jauhar.

12 recordsLinked to original sources

Severity of alcohol dependence in the East End of Glasgow.

A survey of 100 consecutive admissions for alcohol abuse in 1990 highlights the severity of alcohol dependence in the East End of Glasgow. The survey identifies a specific sub-group of heavy drinkers who consume strong lager, usually in open spaces, referred to locally as 'garden parties'. In the total population, males outnumbered females 3:1 with a mean consumption of 268 and 230 units of alcohol per week, respectively. The severity of alcohol abuse was reflected in their social, physical and central nervous system complications. Two-thirds of the population had a family history of alcohol abuse. Over three-quarters of the population showed self neglect with nearly half the males ascribing their marital breakdown or family neglect directly to their drinking problem. Both sexes showed a high prevalence of history of paraesthesiae, while half the male population had clear signs of peripheral neuropathy on admission. A history of delirium tremens in over 50% of the population with a history of seizures in 21% of males and 35% of females indicates central nervous system involvement. Three sub-groups were identified: history of delirium tremens, history of persecutory ideation and history of serious criminality. All three sub-groups had a shorter length of drinking with higher consumption and increased frequency of 'garden parties' than the group as a whole. This survey reinforces the need for appropriate in-patient detoxification and rehabilitation facilities for patients with severe alcohol dependence, to reduce their impact on other health, social work and criminal justice services.

Alcohol Drinking↗

Heroin abusers in psychiatric beds. A Glasgow study.

A retrospective study was carried out of all heroin abusers admitted to an acute psychiatric unit to examine their use of the facility of in-patient care. The compliance with treatment was low. Most patients discharged themselves or were discharged prematurely for using drugs while in the ward; only 21% were discharged as planned. The value of hospital admission in the management of opiate abusers may have to be reconsidered in view of the increasing prevalence of heroin abuse and the limited number of psychiatric beds.

Adolescent↗

Psychiatric morbidity and time zone changes: a study of patients from Heathrow airport.

In a two-year period, 186 patients were admitted from Heathrow Airport to the nearest psychiatric hospital. Affective illness was related to time zone change. Depression was diagnosed significantly more often on flights from east to west (P less than 0.012 east to west versus west to east; P less than 0.015 north to south combined with south to north versus east to west, Fisher's exact probability test, two tailed). Hypomania was inversely related to depression in an east to west comparison (P less than 0.025). No other associations with direction of travel were seen in other diagnoses. Ninety-three (50 per cent) were diagnosed as schizophrenic; 24 of these had been aimlessly wandering. Twenty patients had been admitted at least once before under similar circumstances. Schizophrenic patients from Heathrow constituted 20 per cent of the total number of schizophrenic patients admitted to the hospital during that period.

Aircraft↗

Wernicke-Korsakoff syndrome and the use of brain imaging.

The proportion of patients with Korsakoff psychosis (KP) who have a history of Wernicke's encephalopathy is smaller in recent studies compared to previous studies. Neuropsychological tests, magnetic resonance imaging (MRI), and single photon emission computed tomography were conducted in eight patients with KP, only four of whom had had a documented Wernicke episode. All subjects showed amnesia without intellectual deterioration. MRI abnormalities were seen in each group to the same extent (atrophy of mammillary bodies, to a less extent thalamus and some generalized gyral atrophy). No MRI measure differentiated the groups. Cerebral blood flow showed reduction of flow to the anterior temporal regions bilaterally, extending to the parietal lobes, to the same degree in each group. Despite the small number of patients examined, the study supports the belief that patients with an insidious onset of KP have the same pathology as those with classical Wernicke-Korsakoff syndrome. This raises the question of whether episodes of alcohol withdrawal without adequate thiamine protection result in occasionally subclinical Wernicke's events, followed by a subsequently diagnosable KP.

Adult↗

Increasing incidence of Korsakoff's psychosis in the east end of Glasgow.

A retrospective analysis of all admissions between 1990 and 1995 in a population of 160,000 identified 47 new cases of Korsakoff's psychosis only seven of which were preceded by Wernicke's encephalopathy. There was a higher ratio of females to males, relative to admissions for severe alcohol dependence. It postulated that the increasing incidence may be related to the warning of anaphylaxis and subsequent withdrawal of high-potency parenteral multivitamins with thiamine.

Adult↗