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Biomedical subjects

P Jansa

Publications and source records attributed to P Jansa.

At least 55 records · Page 3Linked to original sources
PubMed1989

Tumor-infiltrating cells and their possible prognostic significance.

1. The introduction presents the most important recent knowledge of tumor immunity. All the known concepts of tumor-infiltrating cells are summarized including the historical background of stromal reaction. Its possible significance in an assessment of prognosis of cancer patients is emphasized. 2. The method of evaluation of this reaction in bioptic preparations is proposed and verified in seven series of carcinomas. The evaluation was directed to quantity, quality and topography of tumor-infiltrating cells. The method is recommended to routine practice for rapid performance, easy applicability, and reproducibility. 3. Cell reaction was evaluated by standard methods in carcinoma of the oral cavity, stomach, larynx, lung, breast, uterine cervix, and kidney. Individual parameters of cell reaction were confronted with clinical data on survival of patients with the aim to determine the possibilities and limits of interpretation of this reaction as a useful prognostic marker. 4. A special attention has been paid to the role of mast cells infiltrating tumors in the course of cancerogenesis in both experimental and human systems. The changes of individual parameters of reaction of tumor-infiltrating cells after regional chemotherapy were studied. Application of histochemical enzymatic reactions in identification of tumor-infiltrating cells is also reported. 5. The final chapter appraises further prospects of the investigation of tumor-infiltrating cells. The factors affecting the variability of this reaction, mechanisms of interactions between tumor-infiltrating cells and the tumor, and utilization of immunohistologic methods employing monoclonal antibodies are discussed.

Antineoplastic Agents↗
PubMed1989

Cell reaction to concanavalin A in cancer patients.

The method of skin window was used in the investigation of cell reaction of healthy volunteers (25 persons) and patients with malignant melanoma (12 cases), breast cancer (18 cases), and with various malignant lymphomas (6 cases) to a local application of the lectin Concanavalin A (Con A, concentration of 10 mg/ml of saline, 0.02 ml per scarification). The obtained results were compared with cell reaction after the application of saline alone. Correlation between cell reaction and clinical state of patients was studied as well. No significant difference in the amount of lymphocytes after the application of Con A was observed between the group of healthy individuals and the group of patients with malignant tumors. On the contrary, the reaction of neutrophil granulocytes to Con A was significantly lower in cancer patients than in healthy volunteers. After the application of Con A, all preparations showed a higher absolute amount of all cells. Con A induced a significant increase in the amount of lymphocytes in patients after therapy and in poor clinical state. The persons with good clinical state reacted by a slight increase or decrease in the number of lymphocytes to the application of lectin.

Antibodies, Monoclonal↗
PubMed1989

Antiphlogistics in periodontology.

In 146 individuals with inflammatory periodontal disease the authors verified the therapeutical effect of Sanchelin (the mixture of sanguinarine and chelerythrine in 0.05% concentration) in gel (4% hydrogel carboxymethylcellulose) applied into pockets and in aqueous solution administered in the intrapapillar route. The effect of Sanchelin in solution was compared with the effect of 2% hydrocortison in the same way of administration. The clinical condition of periodontium and the quality of oral hygiene was evaluated by means of indexes and papillae were examined histologically. The authors demonstrated that Sanchelin in gel is an effective drug in treatment of inflammatory periodontal disease. They observed lesser effectivity when intrapapillar administration of Sanchelin in solution was used.

Anti-Inflammatory Agents↗
PubMed1988

Mucopolysaccharides in gastric cancer.

The histochemical properties of mucus in 48 diffuse type gastric carcinomas and in 46 intestinal type gastric cancers were investigated. In the diffuse type there was a prevalence of intracellular secretion of mucopolysaccharides with a significantly larger portion of sulfated mucopolysaccharides. Acid mucopolysaccharides occurred in the tumor cells only along with neutral ones. In the intestinal type of this cancer, in turn, extracellular secretion prevailed, along with the occurrence of purely acid mucopolysaccharides and a smaller portion of sulfated ones. The secretion of pure neutral mucopolysaccharides in both types of gastric cancer was very low. In the marginal areas of intestinal type carcinomas, incomplete intestinal type IIb metaplasia was frequently found.

Carcinoma↗