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Biomedical subjects

P J van Wattum

Publications and source records attributed to P J van Wattum.

5 recordsLinked to original sources
PubMed2000

Patterns of response to acute naloxone infusion in Tourette's syndrome.

The purpose of this study was to replicate findings from an earlier pilot study in which we found a dose-related effect of the opioid antagonist naloxone on tic behavior in patients with Tourette's syndrome (TS). Fifteen subjects with TS were challenged with randomized doses (30 and 300 microg/kg) of naloxone at 3-day intervals. Videotaped recordings of tic behavior were counted in a "blind" fashion. We found that naloxone had opposite effects on tics at different dosages. The low dose caused a significant decrease in tics, whereas the high dose caused a significant increase in tics. Therefore, activity at opioid receptors appears to influence the expression of TS, and the difference in response to naloxone in TS subjects may be based on a dose-response effect.

Adult↗
PubMed1993

Two-year stability of self-reported problems in an epidemiological sample of adolescents.

This study investigated the stability and change of problems reported by adolescents during a 2-year period. An epidemiological sample of 580 adolescents aged 11-16 at the initial assessment completed the Youth Self-Report on two occasions. We found high stability in the level of Youth Self-Report total problem scores. The highest stability was found for aggressive behavior. Problem scores tended to increase across time. This increase was greater for girls than for boys, especially for the somatic complaints syndrome. Of the adolescents who could be regarded as deviant at the initial assessment, 42% could still be regarded as deviant 2 years later.

Adolescent↗