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Biomedical subjects

P J Robson

Publications and source records attributed to P J Robson.

62 records · Page 4Linked to original sources
PubMed1982

Pharmacokinetics of meptazinol in man following repeated intramuscular administration.

A study was performed in 6 healthy volunteers to determine whether 50 mg intramuscular doses of meptazinol repeated four hourly for 24 h would lead to accumulation of the drug. The first dose of meptazinol was rapidly absorbed with a subsequent mean (+/- SD) elimination half-life of 1.6 +/- 0.33 h. This value was unaffected by the administration of intermediate doses. There was no significant accumulation of the drug; 95% of the steady-state plasma concentration was achieved after a mean (+/- SD) of 1.9 +/- 0.39 and 99% after a mean (+/- SD) of 2.9 +/- 0.63 doses. These findings are consistent with the theoretical prediction for a rapidly absorbed drug with a plasma elimination half-life of 1.6 h. No clinically relevant changes were seen in pulse blood pressure, haematological or biochemical screens. Reported side effects were of a subjective and minor nature.

Adult↗
PubMed1982

Double-blind comparison of meptazinol and pethidine in labour.

The analgesic efficacy and safety of intramuscular meptazinol and pethidine in the first stage of labour were compared in a randomized double-blind trial in 358 patients. Pain relief was measured on a verbal rating scale, maternal side effects were recorded and neonatal outcome assessed in the first 24 h. Pain relief during the first hour after injection was significantly greater in the meptazinol than in the pethidine group at 45 and 60 min. Thereafter, there was no difference between the treatments, and the duration of action was approximately the same. Twenty-eight per cent of patients experienced side effects after meptazinol compared with 35% after pethidine. The commonest were nausea and vomiting with a similar incidence in both groups. Most of the neonatal observations revealed no difference between the two drugs, but significantly more babies whose mothers had received meptazinol had an Apgar score of greater than or equal to 8 at 1 min after birth.

Anesthesia, Obstetrical↗
PubMed1980

Preliminary experience of the use of meptazinol as an obstetric analgesic.

Following an open pilot trial, meptazinol [m(3-ethyl-1-methyl-hexahydro-1-H-azepin-3-yl) phenol hydrochloride] was compared to pethidine in a single-blind study in women requiring analgesia during labour. Meptazinol provided significantly better analgesia than pethidine with similar but possibly less distressing maternal side effects. There were no obvious adverse effects in the newborn.

Apgar Score↗
PubMed1980

Double-blind crossover trial of oral meptazinol, pentazocine and placebo in the treatment of pain in the elderly.

In a randomized, double-blind crossover trial in 30 elderly patients suffering from moderate to severe pain, the analgesic efficacy, tendency to produce mental confusion and side effect profile of meptazinol 100 mg orally were compared with those of pentazocine 25 mg orally were compared with those of pentazocine 25 mg orally and placebo. Both the active drugs produced significantly better analgesia than placebo but meptazinol also provided significantly better pain relief than pentazocine, whilst at the same time causing less mental confusion. Side effects were unremarkable. Meptazinol appears to be a better general purpose oral analgesic in this group of patients than pentazocine.

Aged↗
PubMed1979

A comparison of the respiratory effects of meptazinol, pentazocine and morphine.

The respiratory effects of a new strong analgesic, meptazinol, were compared with a placebo and with equianalgesic doses of morphine and pentazocine in a double-blind crossover trial in seven healthy volunteers. No significant change in the ventilatory response to rebreathing carbon dioxide was observed after meptazinol 100 mg/70 kg or placebo. However, both morphine 10 mg/70 kg and pentazocine 60 mg/70 kg depresesd the slope of the ventilatory response (-30.0% and -31.6% respectively, P less than 0.02, averaged over the first 3.5-h period). End-tidal carbon dioxide tension (PE'CO2) while breathing room air increased significantly following all three drugs. However, the increase in PE'CO2 after meptazinol (0.22 kPa averaged over 3.5 h) was significantly less than that following morphine (0.40 kPa, P less than 0.05) and pentazocine (0.59 kPa, P less than 0.01). While breathing room air with a resistive inspiratory load of 8 kPa litre-1 s, PE'CO2 again increased significantly (P less than 0.05) following all three drugs. The increase in PE'CO2 after meptazinol was then the same as that after morphine (0.51 kPa averaged over 3.5 h). The increase following pentazocine (0.80 kPa) was significantly greater than that after both morphine and meptazinol (P less than 0.02).

Adult↗