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Biomedical subjects

P J Ioannidis

Publications and source records attributed to P J Ioannidis.

11 recordsLinked to original sources
PubMed1982

International transeconomic trends of arterial diseases in the mid-1970s.

In developing countries, a positive linear dependence was found in the relationship between annual mortality from arterial diseases around 1975 and per capita gross national product (GNP). This dependence tends to increase with age. In industrialized countries, negative linear dependence was found for all age groups of both sexes over 35 years of age, decreasing with age. When data from developing and industrialized countries for each age and sex group were pooled, the best fit was given by quadratic regressions with their point of decline shifting toward higher levels of income with increasing age. The dependence of the average annual rate of change of arterial disease mortality at all ages for the period of about 1970-1976 on the per capita GNP for about 1975 for data pooled from developing and industrialized countries was found to be negative, but that is best explained by cubic (sinusoid) regressions after a logarithmic transformation of the independent variable. Finally, the relationship between the average annual growth rate of the per capita GNP and the average annual rate of change of arterial disease mortality between 1970-1975 was insignificant for low growth rates of per capita GNP, yet significantly positive for the higher end of the range.

Adult↗
PubMed1982

Acute myocardial infarction and cerebrovascular accident in a young girl after a viper bite.

A 17-year-old girl developed an acute myocardial infarction immediately after being bitten by a viper and four days later she had a cerebrovascular accident. The close clinical and laboratory follow-up of this case suggested that myocardial damage could be attributed to a direct cardiotoxic effect of the venom, while the brain injury that subsequently appeared was probably the result of a disseminated intravascular coagulopathy, possibly in conjunction with vasculitis.

Adolescent↗
PubMed1976

Short left coronary artery trunk as a risk factor in the development of coronary atherosclerosis. Pathological study.

The relation between the length of the main left coronary artery and the degree of atherosclerosis in its branches was studied by postmortem examination in 204 subjects aged 20 to 90 years. The findings suggest that in cases with a short main left coronary artery the atherosclerotic lesions in the anterior descending and circumflex branches appear earlier, progress faster at higher levels of severity, and lead more frequently to myocardial infarction, than in cases with a long left coronary artery trunk. In cases over the age of 50 years, where disease is expected to have developed, it was shown that the degree of atherosclerosis in the left anterior descending and circumflex branches was inversely related to the length of the main left coronary artery. The correlation coefficients were -0-527 and -0-428, respectively, and in either case a test for zero correlations was significant (P less than 0-001). The possible changes in the haemodynamic and mechanical conditions associated with the variations of the anatomical pattern of the coronary arteries and their influence in the development of atherosclerosis are discussed. It is suggested that the length of the main left coronary artery is a congenital anatomical and possibly hereditary factor influencing the rate of development of atherosclerosis in the branches of the main left coronary artery.

Adult↗
PubMed1976

Length of main left coronary artery in relation to atherosclerosis of its branches. A coronary arteriographic study.

The relation between the length of the main left coronary artery and the presence of atherosclerosis in its branches or the presence of complete left bundle-branch block was studied by selective coronary arteriography in 43 persons. The length of the main left coronary artery was found to be significantly shorter in patients with coronary atherosclerosis than in subjects without angiographic evidence of coronary artery disease. In patients with electrocardiographic evidence of complete left bundle-branch block, the length of the left main coronary artery was significantly shorter than that in both previous groups. In view of these findings, it is suggested that a short main left coronary artery should be considered as a congenital factor predisposing to the development of coronary artery disease. The possible mechanisms leading to atherosclerosis of the left coronary arterial branches in the presence of a short main trunk are discussed.

Angiography↗