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Biomedical subjects

P J Funke

Publications and source records attributed to P J Funke.

24 records · Page 2Linked to original sources
PubMed1980

Complications after extravesical antireflux operations.

The antireflux operation according to Lich-Grégoir (L-G) poses no particular technical problems and involves no major surgical stress to the patient. Of its intraoperative complications lesions to the bladder mucosa have to be considered in the first place. Its postoperative complications calling for reoperation comprise recurrence of reflux, ureteral stricture and ureteral fistula. Results of the Lich-Grégoir operation performed in 176 instances are reported. The complication rate was 4.5 per cent. The complications are commented upon, and the types and time of reoperations are discussed.

Child↗
PubMed1977

Influence of L-thyroxine upon enzymatic activity in the renal tubular epithelium of the rat under normal conditions and in mercury-induced lesions. I. Histochemical studies of alkaline phosphatase, acid phosphatase, adenosine- tri-phosphatase and leucine-aminopeptidase.

HgC12-induced renal tubular lesions in the rat present histochemically with a transitory decrease of alkaline phosphatase, adenosinetriphosphatase (ATPase), and leucine-aminopeptidase activity. The toxic alterations of enzyme activity were more pronounced in the pars recta of the proximal tubule and in the loop of Henle, as compared with the tubulus contortus I. L-thyroxine treatment leads to an accelerated reversal of that enzymatic defect, followinga characteristic pattern, and to a differentiating increase of acid phosphatase and ATPase activity in certain parts of the normal renal tubule. The observations are discussed with reference to the specific mode of action of sublimate and l-thyroxine upon the tubular enzymes and to the well-known metabolic and functional influences of thyroid hormone on the kidney.

Acid Phosphatase↗
PubMed1977

Influence of L-thyroxine upon enzymatic activity in the renal tubular epithelium of the rat under normal conditions and mercury-induced lesions. II. Histochemical studies of lactate dehydrogenase, succinate dehydrogenase, malate dehydrogenase, unspecific esterase, and glucose-6-phosphate dehydrogenase.

Mercury-induced renal tubular lesions in the rat present histochemically with a decrease of succinate dehydrogenase (SDH), malate dehydrogenase (MDH), glucose-6-phosphate dehydrogenase (G-6-PD), and unspecific esterase (UE), but with an increase of lactate dehydrogenase (LDH), indicating a drop of energy supply as well as a switch from oxidative to glycolytic energy production. L-thyroxine has the same effect on SDH, G-6-PD, and LDH, but an inverse effect on MDH and UE, pointing to stimulation of gluconeogenesis. However, administration of L-thyroxine to animals which have been submitted to sublimate intoxication even further decreases the MDH and UE activity while raising or partly restoring the activity of LDH, SDH, and G-6-PD. This observation is interpreted as an attempt of the damaged epithelial cell, as the gluconeogenesis ceases, to gain relatively more energy supply for the benefit of the vitally indispensable tubular Na+ reabsorption.

Acute Kidney Injury↗
PubMed1975

[The position of the renal pelvic axis in the infant (author's transl)].

The position of the longitudinal axis of the renal pelvic system is of special significance in the diagnosis of renal pelvic reduplications, horseshoe kidneys and space occupying processes of the kidney. The present study of 143 normal infant urograms shows that the angle between the axis of the renal pelvis and the axis of the vertebra is dependent on age. While in the newborn a negative angle is a common finding, during adolescence the axis approaches the position we usually find in the adult.

Adolescent↗