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Biomedical subjects

P J Fitzpatrick

Publications and source records attributed to P J Fitzpatrick.

At least 73 records · Page 4Linked to original sources

3D image reconstruction of right subclavian artery aneurysms.

OBJECTIVE: Three-dimensional (3D) image reconstruction methods allied to spiral CT (SCT) or MR angiography (MRA) are used in clarifying the anatomy of complex aortic anatomy. MATERIALS AND METHODS: Two patients with superior mediastinal masses suggestive of aneurysms of the anomalous right subclavian artery were examined. Both patients were examined using breath-hold SCT and one by breath-hold MRA. Three-dimensional images were reconstructed using a surface rendering technique for the SCT examinations and by a maximum intensity projection technique for MRA. RESULTS: Two cases of aneurysmal anomalous right subclavian artery were diagnosed by SCT with 3D image reconstruction. One case was also examined by MRA with 3D image reconstruction which confirmed the findings of SCT. The use of the 3D techniques clarified the complicated anatomy and avoided the need for angiography. CONCLUSION: Two cases are illustrated of 3D imaging of complicated aortic branch anatomy due to aneurysms of anomalous right subclavian artery. Image quality was good and no further imaging by more invasive techniques was required.

Aged↗

Half-body radiotherapy. Evaluation of the technique in normal dogs.

Eight healthy mongrel dogs were treated with half-body irradiation (HBI) in a pilot study to evaluate the technique and radiotolerance of different organs. Cranial and caudal half-body fields were established using the 13th thoracic vertebra as the dividing point. Under general anesthesia, either 7 or 8 Gray (Gy) were delivered to one half of the body using opposing radiation portals. The other half of the body was similarly treated 28 days later. The dogs were monitored for 12 months. Significant radiation effects included transient bone marrow suppression and radiation sickness. There were no serious or life-threatening problems, but the 8 Gy group consistently showed more severe clinical signs and histologic changes than the 7 Gy group. Total body irradiation in two fractions of 7 or 8 Gy given 1 month apart appears to be a safe treatment that can be developed for therapy in veterinary oncology.

Animals↗