Search PubMed⌕ Search

Biomedical subjects

P J Bos

Publications and source records attributed to P J Bos.

At least 19 recordsLinked to original sources
PubMed1997

Presumed ocular histoplasmosis in The Netherlands--an area without histoplasmosis.

AIMS/BACKGROUND: The syndrome of ocular histoplasmosis is usually prefaced by "presumed' as the aetiology is not yet clear. The aim of this study was to evaluate the clinical features of a similar ocular syndrome in the Netherlands where the fungus Histoplasma capsulatum is not endemic. METHODS: A retrospective multicentre study in which all patients were included who were diagnosed with a syndrome similar to presumed ocular histoplasmosis and in whom both fluorescein angiogram and all complete patient data were available. Fluorescein angiograms were examined by three authors in a masked fashion. Eighty one patients were selected who fulfilled the ophthalmic criteria for presumed ocular histoplasmosis. Fifty one patients showed the classic clinical picture, while 30 patients had an incomplete form as they did not show numerous histospots. RESULTS: No major difference in clinical characteristics could be identified when comparing the group of patients with the classic syndrome with the one with the incomplete syndrome. Final visual outcome of patients with macular subretinal neovascularisation after laser treatment was better when compared with untreated patients (p < 0.01). CONCLUSIONS: Since the fungus Histoplasma capsulatum is absent in the Netherlands, other aetiological agents must have led to this clinical entity similar to the presumed ocular histoplasmosis syndrome seen in the USA.

Adolescent↗
PubMed1993

Birdshot chorioretinopathy and Lyme borreliosis.

Two patients in whom ocular Lyme disease was suspected and who had antibodies to Borrelia burgdorferi developed birdshot chorioretinopathy and carried the HLA-A29 antigen. In a series of 11 patients with birdshot chorioretinopathy who carried the HLA-A29 antigen, three patients had antibodies against B. burgdorferi as determined by either immunofluorescence assay, enzyme-linked immunosorbent assay, Western blot analysis, or a combination of these tests. Further studies will be necessary to evaluate whether this is a false-positive reaction or whether B. burgdorferi has a causative role in the pathogenesis of birdshot chorioretinopathy.

Blotting, Western↗
PubMed1992

Reappearance of vanished bile ducts.

A 36-year-old Surinam woman with a severe form of toxic epidermal necrolysis of unknown origin is presented. Skin lesions healed gradually without scarring within 3 to 4 weeks, but eye lesions progressed to symblepharon and corneal opacification, resulting in almost complete blindness. In addition, toxic epidermal necrolysis was associated with severe intrahepatic cholestasis caused by vanished bile duct syndrome; viral hepatitis, primary biliary cirrhosis and primary sclerosing cholangitis were excluded. After about six months, intrahepatic chole-stasis improved spontaneously and a third liver biopsy taken after 51 weeks of illness revealed that the bile ducts had reappeared. At present, the patient is relatively well, with no jaundice, although parameters of cholestasis are still elevated: Alkaline phosphatase three times, and gamma GT thirty times the normal values. This sequence of events has to our knowledge never been reported in the literature.

Adult↗
PubMed1990

Familial vascular retinopathy. A preliminary report.

We describe a new hereditary syndrome with an autosomal dominant mode of inheritance, with vascular retinopathy, migraine and Raynaud's phenomenon as the most striking features. The retinopathy is characterized by tortuosity and variable caliber of the retinal vessels, haemorrhages, telangiectases and both central and peripheral vascular occlusions, leading finally to a proliferative retinopathy.

Fluorescein Angiography↗
PubMed1989

Angle-closure glaucoma in a patient with systemic lupus erythematosus.

A patient is described known with ITP, who developed an attack of angle-closure glaucoma secondary to posterior scleritis. This condition reacted well to corticosteroid treatment and antiglaucomaleus therapy serologically SLE was highly probable. In fundo there was the picture of a central retinal vein occlusion. Later the patient developed neovascularisation of the optic disc, which did not diminish after panretinal photocoagulation. In spite of cryocoagulation, a vitreous haemorrhage resulted.

Adrenal Cortex Hormones↗
PubMed1986

Neuroretinitis in secondary syphilis.

A 30-year-old man with bilateral neuroretinitis and uveitis associated with secondary syphilis is described. Characteristic lesions on the palms of the hands and the soles of the feet gave us the clue to the diagnosis. Treatment with penicillin resulted in a rapid cure. Syphilic neuroretinitis is often associated with secondary meningitis. Early diagnosis and adequate therapy are important in this serious but treatable condition.

Adult↗
PubMed1986

Aqueous chamber taps in toxoplasmic chorioretinitis.

The clinical value of the determination of toxoplasma antibodies in anterior chamber taps was evaluated in 12 posterior uveitis patients suspected of a toxoplasmic retinochoroiditis, in four patients with Fuchs's heterochromia and in 31 cataract patients. The posterior uveitis patients all had marked inflammation of the vitreous obstructing the examination of the fundus of the time of aqueous humour aspiration. The clinical diagnosis toxoplasmic uveitis (n = 9) was made after the inflammation of the vitreous had subsided and fundus examination became possible again. Paired serum and aqueous samples were tested for total immunoglobulin levels and toxoplasma antibodies. Eight of the nine clinical toxoplasmic uveitis patients had detectable toxoplasma antibodies in their aqueous, whereas none of the other seven uveitis patients were positive. All of these eight toxoplasmic uveitis patients had a coefficient above 1.5. Of the 31 control patients only one had a positive antibody titer at a dilution of 1/2 with a corresponding coefficient of 1.1. This study shows that aqueous humour examination for toxoplasma antibodies is a valuable diagnostic tool in a selected group of posterior uveitis patients.

Antibodies↗
PubMed1986

Kaposi's sarcoma of the conjunctiva and CMV-retinitis in AIDS.

The number of AIDS patients is still increasing. In 30-50% of these patients ocular lesions occur, which are of diagnostic and prognostic significance. If the life-span of AIDS patients lengthens in the future, adequate treatment of the ocular conditions will become increasingly important. The two most important ocular manifestations AIDS are CMV-retinitis and Kaposi's sarcoma of the conjunctiva. DHPG, a new virustatic for human cytomegalovirus, appears promising as treatment for the severe CMV-retinitis, which leads rapidly to blindness. Two case histories illustrate the preliminary results obtained with DHPG treatment. Kaposi's sarcoma of the conjunctiva is relatively benign is AIDS and can be treated successfully by surgical excision, radiotherapy, cryotherapy or local injections of cytostatics.

Acquired Immunodeficiency Syndrome↗
PubMed1983

Vitrectomy in two cases of bilateral Terson syndrome.

We report on two patients with bilateral vitreous haemorrhage after a subarachnoid haemorrhage (Terson syndrome). We performed vitrectomy in four eyes with complete recovery of vision in three eyes; one eye had visual acuity of 1/6 due to preretinal fibrosis. The patient who had 20/20 vision in both eyes had a retinal detachment in one eye two months after the vitrectomy; this was operated upon and vision did not deteriorate.

Eye Diseases↗
PubMed1983

Treatment of glaucoma simplex with argon laser coagulation of the scleral spur (L.S.S.C.).

Wise and Witter published in 1979 the results of argon laser treatment of glaucoma simplex. They coagulated in and just behind the trabeculum using as little energy as possible (+/- 100 coagulations, 50 mu, 1/10 sec, 80-1500 mWatt, spaced over 360 degrees). As we consider that coagulation of the trabeculum is not entirely without risk, we modified the technique by placing the lesions in the scleral spur. Up to the end of 1981, 84 eyes had been treated in 69 patients. Of 28 eyes in which treatment had taken place at least 1 year ago, the results in twenty-five were able to be analysed. The average decrease in pressure one year after treatment was 6.5-8.5 mm Hg (+/- 30% of the original value). The coefficient of outflow was measured in 10 eyes before and after treatment. This rose from an average of 0.11 (+/- 0.03) to an average of 0.18 (+/- 0.02).

Aged↗
PubMed1982

Argon laser treatment of pigment epithelial detachments and of subretinal neovascular membranes in Junius-Kuhnt's senile disciform macular degeneration. A prospective, randomized study.

Results of argon laser treatment of pigment epithelial detachments and of subretinal neovascular membranes in Junius-Kuhnt's senile disciform macular degeneration have been compared in a prospective, randomized investigation with the natural course of these affections. Of several hundred cases 26 eyes met our criteria for treatment. In control periods ranging from 1 to 3 years, six eyes with pigment epithelial detachments received laser treatment and seven served as controls; seven eyes with subretinal neovascular membranes received laser treatment and six served as controls. The results indicate that impairment of vision progresses more rapidly after argon laser treatment than when no such treatment is given.

Adult↗