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Biomedical subjects

P J Berretty

Publications and source records attributed to P J Berretty.

At least 19 recordsLinked to original sources
PubMed2000

[A new option for skin rejuvenation: CO2-laser resurfacing].

Resurfacing denotes mechanical, chemical or physical removal of the superficial layers of aging skin, after which collagenesis is reactivated with improved epidermal architecture as a result. CO2 laser resurfacing is a modern technique for the treatment of skin aging. With CO2 laser resurfacing it is possible to perform accurate ablation of layers of the skin. Besides the cosmetic indications, this technique is a good treatment modality for a broad spectrum of dermatological diseases.

Carbon Dioxide↗
PubMed2000

Cosmetic results of cryosurgery versus surgical excision for primary uncomplicated basal cell carcinomas of the head and neck.

BACKGROUND: The incidence of multiple facial basal cell carcinomas (BCCs) is increasing. OBJECTIVE: Comparison of cosmetic results after cryosurgery and excision for primary BCCs. METHODS: Cosmetic results after cryosurgery and excision (prospective randomized study) of primary BCCs in the head/neck area were assessed by five independent professional observers and by the patients. RESULTS: Ninety-six BCCs were treated either with surgical excision (n = 48) or cryosurgery (n = 48). Clinical professionals evaluated the cosmetic results after surgery as significantly better. The beautician had no preference for either therapy. The patient had a significant preference for excision. Localization and size of the tumor did not modify this general preference for excision. The male dermatologist, however, had a tendency to evaluate results in the cheek, periauricular, and neck area as inferior to those in the rest of the face, regardless of which therapy was given. CONCLUSION: In general, cosmetic results after excision are better than after cryosurgery.

Adolescent↗
PubMed1998

[The treatment of basal cell carcinoma patients by dermatologists in Netherland].

OBJECTIVE: To determine the policy of dermatologists practising in the Netherlands in the treatment of basal cell carcinoma. DESIGN: Written enquiry. SETTING: Catharina Hospital, Eindhoven, the Netherlands. METHOD: All 293 dermatologists practising in the Netherlands were sent a questionnaire in May 1996 containing 15 questions about diagnosis and treatment of basal cell carcinoma. RESULTS: Eighteen forms dropped off because of termination of the practice or joint completion in group practices. The response was 76% (208/275). The diagnosis was made usually on the basis of histological examination (71% of the respondents; 84% in a tumour recurrence). Excision was the preferred treatment for all subtypes of basal cell carcinoma; second choices were cryosurgery or curettage/electrocoagulation. Roentgen contact therapy has been practically abandoned. New methods such as photodynamic therapy and immunotherapy are being used only sporadically on an experimental basis. Most dermatologists regarded tumour recurrences as a bigger problem than primary tumours. They attempt to reduce the percentage of recurrences by giving advice about risk factors (sunlight). CONCLUSION: Too little use is being made of diagnostic biopsy to enable an optimal choice of therapy of basal cell carcinomas, especially in cases of recurrence tumours.

Basal Cell Carcinoma↗
PubMed1994

[Effective treatment of recurrent keratoacanthoma using methotrexate].

Three patients, two men aged 54 and 72 years, respectively, and a woman aged 52 years, were treated successfully for (recurrence of a) keratoacanthoma with methotrexate. Since the sixties 11 patients with recurrent keratoacanthoma treated with methotrexate have been described. Dose schedules were widely different and dosages were in general high, resulting in more or less severe side effects. The patients now presented were treated according to the Weinstein schedule, with small doses and during a short period, which minimises the adverse effects.

Aged↗
PubMed1993

Lack of selective attendance of participants at skin cancer/melanoma screening clinics.

BACKGROUND: Whether persons who come for skin cancer/melanoma screening are those at highest risk for the disease remains a debatable issue. OBJECTIVE: Our purpose was to evaluate the appropriateness of self-selection of persons attending screening clinics. METHODS: We studied the frequency of malignant and/or premalignant clinical diagnoses according to certain demographic characteristics as a measure of selective attendance among 2463 persons screened in the regions of Arnhem and Eindhoven in 1990. RESULTS: The referral rates for tentative malignant and/or premalignant diagnoses were more or less similar in men (11.8%) and women (9.6%); in persons with symptoms (11.6%) and those who were symptom free (9.3%); in attendants from the towns in which the screenings were held (11.4%) and those coming from distant communities (9.0%); and in persons who attended for specific skin lesions (10.7%) and those who opted for general skin examination (8.8%). The referral rate was 9.2% in persons younger than 70 years of age against 18.5% in those 70 years of age or older (p < 0.001). Most presumptive melanoma diagnoses (15 of 22) were recorded in persons 50 years of age or older. CONCLUSION: Our findings suggest that participants of free skin cancer/melanoma screening clinics, on average, are unable to estimate their own risk profile properly.

Adult↗
PubMed1993

General practitioners' workload after skin cancer/melanoma screening clinics in The Netherlands.

We studied the workload of the general practitioner after two skin cancer screening clinics in the Netherlands. Thirty-one physicians participated in the project. The numbers of patients presenting with benign and malignant skin lesions were recorded 2 weeks before and 6 weeks after the public campaigns. In the week immediately after the screening there was a small increase in the number of consultations for suspected skin cancer. Thereafter, the weekly number of malignant lesions decreased to precampaign levels. Subsequently to the campaigns the numbers of referrals for benign skin lesions decreased slightly. We conclude that the extra workload for the general practitioner generated by the screening campaigns has been negligible.

Family Practice↗
PubMed1982

[Immunoglobulin deposits in vascular walls in cutaneous lupus erythematosus. Immunofluorescence study].

This paper reports an immunofluorescence (IF) study of the skin of 16 patients with chronic discoid localised lupus erythematosus and 5 patients with cutaneous disseminated lupus erythematosus. In the majority of the cases (18), we have found immunoglobulin and complement deposits not only along the dermoepidermal junction, but also in the blood vessel walls. In these deposits there was a predominance of IgM. It appears that an immune complex vasculitis in the skin can be found in patients from the entire lupus erythematosus spectrum. The discovery of immunoglobulins and complement deposits in the blood vessel walls of the involved skin of patients with discoid lupus erythematosus, suggests that it can be considered as an important (and even characteristic) feature of the disease.

Adult↗
PubMed1981

Hepatitis B surface antigen deposition in the blood vessel walls of urticarial lesions in acute hepatitis B.

Urticaria is known to occur in the pre-icteric phase of acute viral hepatitis. Often such urticaria is a symptom of a serum sickness-like syndrome which can be a prodrome of viral hepatis. Immune complexes are thought to be pathogenetic in this condition. In this paper we present two patients with a serum sickness-like syndrome, urticaria and hepatitis B. By immunofluorescence techniques Hepatitis B surface antigen, CIq and C3 could be demonstrated in the blood vessels of the superficial dermis. These findings are consistent with the immune complex hypothesis.

Adult↗
PubMed1981

Eosinophilic granulocytes and skin disorders.

The eosinophilic granulocytes remain intriguing cells. At the moment there are several skin disorders such as incontinentia pigmenti (Siemens-Bloch), pustulosis of the newborn, etc, in which the presence of eosinophils has not yet been studied. Basic aspects of the function of the eosinophils and their relationship with other inflammatory cells are being eliminated gradually. In the near future it will become clearer why, in certain circumstances, eosinophils are necessary or undesirable. These new data will be of great significance for clinical dermatology and skin pathology. In what circumstances do the eosinophils modulate inflammatory reactions and when do the cytotoxic capacities come to the fore? Other chemotactic factors will be detected, especially those related to the local inflammatory cells, lymphocytes, macrophages, and polymorphonuclear leukocytes. With the aid of these findings it will be possible to understand better why eosinophilic granulocytes are present in different skin disorders. Finally, regulation and influence of their behavior may become a possibility.

Antigen-Antibody Complex↗
PubMed1981

Granulomatous secondary syphilis coinciding with PUVA treatment in a patient with psoriasis: an apparent failure of PUVA therapy.

A 39-year-old man is described who has been suffering from psoriasis for many years. Because of the extensive involvement of the skin he was treated with PUVA therapy, initially with a good result. A second course of PUVA treatment was unsuccessful. Histopathological examination of the (persisting) skin lesions at this time showed clear granulomatous infiltration, in addition to psoriatic changes. Based on history, serological and dark-field examination, a secondary syphilis was diagnosed. The possible influence of PUVA therapy is discussed.

Adult↗