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Biomedical subjects

P Isaacs

Publications and source records attributed to P Isaacs.

31 records · Page 2Linked to original sources
PubMed1984

Marathon without a colon: salt and water balance in endurance running ileostomates.

Five trained ileostomates completed a marathon in a cool environment without ill effect. During the race, the ileostomy losses of sodium (1.0-2.7 mmol.h-1) and of water (9.2-19 ml.h-1) were small, but urinary excretion of sodium was very low (0.2-0.75 mmol.h-1) despite drinking a combination of water and glucose-electrolyte solution. The concentration of potassium in the ileostomy discharge tended to increase, also suggesting a sodium retaining state. Healthy ileostomates after suitable training are successful marathon runners, but the prevalence of mild salt depletion in ileostomates generally suggests that it may be advisable for them to take only glucose-electrolyte solutions when competing at any ambient temperature or when preparing for a marathon which is to take place in a warm environment.

Adult↗
PubMed1983

Idiopathic intestinal pseudo-obstruction and contaminated small bowel syndrome--treatment with metronidazole, ileostomy, and indomethacin.

A 28-year-old Iranian man with chronic idiopathic intestinal pseudo-obstruction presented with gross features of contaminated bowel syndrome. Treatment with metronidazole reversed steatorrhea but exacerbated the gaseous distention of the small intestine, precipitating emergency surgical decompression and ileostomy. A chronic high volume ileostomy diarrhea ensued and was successfully treated with oral indomethacin.

Adult↗
PubMed1981

Non-specificity of elevated serum ribonuclease as a pancreatic tumour marker.

Differences in heart stability of human pancreatic ribonuclease (cRNase) and serum ribonuclease were abolished by aprotinin, suggesting that the pancreatic enzyme was similar to the serum enzyme, but was being destroyed by proteases. Serum ribonuclease levels in normal subjects correlated with age but were unaffected by meal ingestion. Serum ribonuclease was not found to be useful in the detection of pancreatic cancer and was more frequently abnormal in patients with other solid tumours or renal failure.

Adult↗