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Biomedical subjects

P Innocenti

Publications and source records attributed to P Innocenti.

At least 91 records · Page 5Linked to original sources
PubMed1983

[Clinico-statistical evaluation of the simultaneous clearance of sulfobromophthalein and galactose in chronic liver diseases].

Sulfobromophthalein dye test and galactose tolerance test were performed, using both substances simultaneous i.v. injection, in 48 subjects with chronic persistent hepatitis, chronic active hepatitis and liver cirrhosis (with and without ascites). As control group 10 normal subjects were tested. Sulfobromophthalein excretion constant ( K1BSF ) drawn from the first part of the retention curve, and the galactose excretion constant (K Gal) were considered. The following conclusions were obtained: a) K1 BSF and K Gal are well-correlated; b) K1 BSF appears more sensitive for a whole evaluation of liver involvement, in absence of evident jaundice (total serum bilirubin less than 6 mg/100 ml); c) K Gal is less reliable in presence of ascites because of the artificial increase in galactose plasmatic clearance provoked by the substance passage to the effusion fluid; d) the statistical analysis using discrimining function methods makes possible a better distinction among the various kinds of liver diseases; e) the same type of statistical analysis shows a difference between cirrhotics with ascites responding to medical therapy in comparison to treatment- resistent ascites. This fact may account for a different level of hepatic functional activity.

Galactose↗
PubMed1982

Antihypertensive activity of once daily metoprolol alone and with chlorthalidone and comparison with a twice daily regimen.

In a multicentre, double-blind (DB), within-patient study, the antihypertensive effectiveness and tolerability of two oral administration schedules of metoprolol (M) 100 mg b.i.d. versus 200 mg once daily (o.d.), were investigated in 103 outpatients with mild to moderate essential hypertension. The study lasted 14 weeks and was divided into 3 periods: a) a weeks of single-blind (SB) placebo wash-out; b) 4 weeks of SB administration of M 100 mg b.i.d.; at the end of the second week of this period, chlorthalidone (C) 25 mg was added in patients with a recumbent diastolic blood pressure (BP) still greater than 95 mmHg and was continued throughout the following period; and c) DB cross-over administration of M 200 mg/d for 4 weeks on a b.i.d. schedule and 4 weeks on a once daily schedule. In comparison with pretreatment values, heart rate and systolic and diastolic BP were reduced (p less than 0.001) by both M administration schedules; there was no differences between the once and twice daily treatment regimens. During M once daily, betablockade was still maintained over 24 hours or longer, as the heart rate remained significantly lower than the basal value. In 57 patients, C was added at the end of the second week of SB M administration, and a further decrease in BP was observed; again, there was no significant change during once and twice daily M administration. Unwanted effects during M treatment were of minor severity, and the majority occurred when C, too, was added.

Administration, Oral↗
PubMed1981

A fixed combination of oxprenolol slow-release and chlorthalidone once daily in treatment of mild to moderate hypertension.

In a multicenter, single-blind, interpatient study, 103 outpatients with mild to moderate hypertension were given, after 2 weeks of placebo wash-out, 160 mg oxprenolol slow-release in fixed combination with chlorthalidone (20 mg per tablet) (SROC 160) once daily or conventional oxprenolol (80 mg) in fixed combination with chlorthalidone (10 mg per tablet) (COC 80) twice daily for 8 weeks. Throughout the study 22 of 51 patients on SROC 160 and 24 of 51 on COC 80 received 1 tablet once daily and, respectively, 1 tablet twice daily. The remaining patients of both groups double the corresponding dosage after the first 4 weeks. Systolic and diastolic blood pressure decreased on both treatments without and difference observed between the groups. Diastolic blood pressure normalization was achieved in both groups in the same number of patients (35). Minor side effects occurred on both treatments: only one patient on SROC 160 interrupted the study due to severe dizziness and fatigue. The advantages are discussed as regards patient's compliance with administration of fixed combination SROC 160 once daily in treatment of mild to moderate hypertension.

Adult↗
PubMed1980

[Postheparin diamineoxidase (DAO) increase in the plasma and gastrointestinal mucosa (author's transl)].

Haparin given i.v. in doses of 50 I.U./kg/body weight induces in the man a synchronous increase of plasmatic and gastrointestinal mucosa Diamineoxidase (DAO) bioptically obtained in course of gastroscopy. The DAO increase is maximum 5 min after heparin injection, and afterwards less evident. The possible practical meaning of the use of DAO increasing substances and so for histamine catabolism in digestive apparatus mucosa is discussed.

Adult↗
PubMed1980

[Clinical significance of diamine oxidase (DAO) in serous effusions of neoplastic and non neoplastic origin (author's transl)].

Diamine oxidase (DAO) levels were investigated in pleural and ascitic fluids of 142 patients suffering from neoplastic and non neoplastic diseases. While in serous effusions of non neoplastic origin or of neoplastic origin (but non containing neoplastic cells) DAO levels were similar to serum levels; in the malignant fluids containing cells of epithelial origin, DAO was very elevated and largely superior to serum values. This results seems to be of practical importance for diagnostic purposes because points out the presence of carcinomatous cells in the effusions.

Amine Oxidase (Copper-Containing)↗
PubMed1980

[A comparative evaluation of metoprolol and methyldopa in hypertension therapy (author's transl)].

The antihypertensive effect and the tolerability of the cardioselective beta-blocking drug metoprolol, in comparison to methyldopa, were assessed in 119 hypertensive patients (73 WHO stage 1 and 46 WHO stage 2). After 2 weeks of placebo wash-out, the patients were randomly allocated to treatment with either of the two drugs: metoprolol up to 200 mg bid, and methyldopa up to 500 mg bid, for 6 weeks. Periodical clinical, biochemical, haematological, radiological and electrocardiographical measurements were performed. In respect to pre-treatment values, heart rate, both in lying and standing position, was significantly reduced (P less than 0.01) only in the metoprolol group, while systolic and diastolic blood pressures were significantly reduced (P less than 0.01) with both drugs in both positions. Asymptotic regression analysis showed that velocity of blood pressure reduction was comparable with both drugs. In the lying position, the diastolic blood pressure reduction obtained with metoprolol was significantly greater (P less than 0.05) in respect to that obtained with methyldopa. In general, side effects were few and of mild severity: mainly bradycardia in the metoprolol group and dizziness and fatigue in the methyldopa group. After the formal end of the double-blind trial, 36 patients, 14 in the metoprolol group and 22 in the methyldopa group, were treated in open conditions with metoprolol alone; after an average period of 6.5 weeks, diastolic blood pressure was significantly reduced (P less than 0.05) only in the group previously treated with methyldopa. In conclusion, metoprolol is a well tolerated and effective antihypertensive agent, which may be safely used in patients with mild to moderate hypertension.

Adult↗
PubMed1980

Antihypertensive activity of a fixed combination of oxprenolol and chlorthalidone in mild to moderate arterial hypertension.

In a multicentre double-blind study, 92 out-patients with mild to moderate hypertension who had a resting blood pressure greater than or equal to 160/100 mmHg after a two-weeks' placebo wash-out were treated for 6 weeks with a fixed combination of oxprenolol 80 mg + chlorthalidone 10 mg per tablet or chlorthalidone alone (1 tablet = 10 mg). Five patients were drop-outs, 19 out of 44 patients on fixed combination and 7 out of 43 on chlorthalidone were given only 1 tablet b.i.d. throughout the study; the remaining doubled the corresponding dosage after the first 2 weeks. Resting and standing systolic and diastolic blood pressure decreased on both treatments, the reductions being significantly more marked on fixed combination in comparison to chlorthalidone alone (p < 0.01 and p < 0.05). The systolic blood pressure decrease was significantly greater on fixed combination from the first week of treatment (p < 0.05). Normalization of diastolic blood pressure was reached more frequently on fixed combination (73%) than on chlorthalidone (49%) (p < 0.05). Side-effects were recorded in 14 out of 44 patients treated with fixed combination and in 14 out of 43 treated with chlorthalidone. The advantages of treating patients with mild to moderate hypertension with a fixed combination of beta-blocker and diuretics are discussed.

Chlorthalidone↗
PubMed1979

[Transplantation of the kidney in the rat. I. Problems of surgical technic].

Is described a technique for transplanting rat kidneys. The technique involves suture of vessels of less than 1 mm in diameter with microsurgical techniques. Were used adult male rats of wistar strain. The kidney is perfused with 250 cc of ringer lactate, heparin 10.000 U.I., solumedrol 1 g novocain 150 mg. The results were very good.

Animals↗
PubMed1979

[Carcinoma of the convergence of the hepatic ducts. A case treated with extended hepatic resection].

The case of a patient with carcinoma of the convergence of the hepatic ducts successfully treated with more extensive hepatic resection is reported. Stress is laid on the problems of exact preoperative diagnosis and of treatment. Most operations are in fact purely palliative and the literature contains very few cases of hepatic resection for neoplasia of the convergence.

Bile Duct Neoplasms↗
PubMed1979

[Metabolic changes after extended hepatic resection].

Two cases of right hepatic lobe resection, one due to trauma and the other to echinococcosis. Adequate support therapy can be used to control the protein, lipid and sugar metabolic changes that occur after this operation. The seriousness of the postoperative course is related to the amount of healthy tissue removed.

Adult↗
PubMed1979

[Preliminary experience in extracorporeal renal surgery and autotransplants].

Successful management of stenosis of a polar branch of the renal artery by means of autotransplantation is reported. The main indications for this technique are described: arteriosclerosis and injury to the artery, aneurysm, various forms of ureteral injury, bilateral or unilateral renal tumour, coralliform intraparenchymal lithiasis, together, with the techniques for extracorporeal perfusion of the kidney and the mechanisms of the more commonly adopted conservation solutions.

Aneurysm↗