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Biomedical subjects

P Imbert

Publications and source records attributed to P Imbert.

At least 73 records · Page 4Linked to original sources
PubMed1994

[Malaria in children at the Sihanoukville Hospital (Cambodia)].

The authors have studied 68 children admitted with malaria in Sihanoukville Hospital (Cambodia) from December 1992 to April 1993. Sihanoukville is located on coast of the country, in a hypoendemic area with seasonal transmission occurring during this study. The patients lived in urban (1/3) or in rural areas (2/3). Plasmodium (P.) vivax alone was found in 15 cases. Among them, two patients presented with severe malaria, but chloroquine was efficient in all cases. P. falciparum with or without P. vivax, was predominant (53 cases). Most of these cases were severe, according to WHO criteria (n = 43), from which 11 deaths occurred (25%). There were 26 cases of cerebral malaria, with a death rate of 34.6%. A severe course was observed with the following criteria: prostration or coma (p = 0.029), severe anaemia (p = 0.037) and hyperparasitaemia (p = 0.00078). A significant longer delay for treatment and admission was noted among rural patients (p = 0.023 and p = 0.011 respectively). In those children, hyperparasitaemia, poor clinical status on admission and lethality were more frequent. The clinical course was not clearly improved with the addition of erythromycin in the quinine regimen. No quinine resistance was observed in this data.

Cambodia↗
PubMed1993

Serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1 beta) in dengue-infected patients.

Sensitive immunoenzymatic assays were used to study the levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and IL-1 beta in sera from dengue-infected patients obtained during the 1989-1990 outbreak of dengue-3 in Tahiti, French Polynesia. The patients, both children (n = 47) and adults (n = 18), were clinically classified as having dengue hemorrhagic fever (DHF) and graded according to the severity of illness (grade I = fever, grade II = fever with spontaneous hemorrhagic manifestations, grade III = circulatory failure, grade IV = deep shock). The serum samples were obtained from day 1 to day 10 after the onset of the disease. High levels of TNF-alpha were observed in dengue-infected children of all severity grades. The highest values of TNF-alpha were found before day 6 after the onset of the infection, these values decreased from day 6 to day 10. The highest values were observed in sera from grade III and IV patients. High values of IL-6 were observed in serum samples of grade I and II patients on day 1, which decreased on day 4, and by day 5 were similar to those obtained from 25 control children. In grade III and IV patients, the highest values of IL-6 were observed from day 3 to day 5 after the onset of infection; after day 5, these values were very low.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1993

Spleen rupture in a patient with dengue fever.

A case of rupture of the spleen is described secondary to dengue 1 fever in an adult patient. This exceptional complication occurred during an outbreak of dengue in French Polynesia. After failure of conservative management, splenectomy was performed. Examination of the surgical specimen confirmed softening and enlargement organ with the formation of a subcapsular hematoma.

Adult↗
PubMed1990

[Bilateral corneal neovascularization and floppy eyelid syndrome. A case report].

The conjunctival and corneal lesions usually observed in the floppy eyelid syndrome are benign and reversible as soon as the specific treatment of superior palpebral hyperlaxity is performed. A case of bilateral corneal vascularization, a rare but severe complication of floppy eyelid syndrome is reported. The floppy eyelid syndrome was identified late because keratoconjunctivitis was clinically predominant and palpebral tonicity was not initially considered. The treatment of palpebral hyperlaxity was the prerequisite for good results with keratoplasty.

Aged↗
PubMed1989

[Treatment of reflex algoneurodystrophies by sympathetic blockade with guanethidine].

Reflex sympathetic dystrophy (RSD) can be treated by regional sympathetic blockade with guanethidine. This method was used systematically in 25 patients with post-traumatic RSD of the upper (n = 8) or lower limb (n = 17). Sixty three blocks were performed, each patient receiving 1 to 4 blocks. The results were appreciated by the effects after one month on pain, mobility and trophic changes. They were excellent in 7 cases, good in 4 cases and poor in 7 cases. The results were better in moderate RSD without psychiatric overlay. Thirteen patients were cured after 3 months. Pain decreased significantly 2 days after injection in 28 of the 63 blocks. The effects on mobility and trophic changes always occurred after the analgesic effect. No side effects were observed with the exception of one patient who had a convulsion 2 hours after the injection. These results show that regional sympathetic blockage with guanethidine is useful for the treatment of RSD, especially in its moderate stages. In view of the negligible risks and its efficacy, the authors consider it to be the first line treatment of moderate RSD.

Adult↗