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Biomedical subjects

P I Kosmach

Publications and source records attributed to P I Kosmach.

11 recordsLinked to original sources
PubMedDate not supplied

[Effect of insulin on the reactivity of the myocardium to hydrocortisone].

Experiments were conducted on rats. A study was made (with the aid of histological and histochemical methods) of the effect of administration of hydrocortisone, insulin, and also of the combined administration of these hormones on the myocardial structure and metabolism. Hydrocortisone administration for 30 days proved to derange the metabolism and to cause dystrophic changes in the myocardium. In combined administration of hydrocortisone and insulin these dystrophic changes were much less pronounced.

Acetylcholinesterase↗
PubMedDate not supplied

[Functional and morphological changes in the islands of Langerhans in obesity].

Functional changes in pancreatic islets seen in obese patients were compared with morphological and ultrastructural alterations in islet cells in rats during varying time of the experimental hypothalamic obesity development. The blood level of insulin and C-peptide in obese patients increases with the disease severity, but functional B-cell reserves tend to decrease as shown by glucose tolerance test. Reduction in glucagon release is seen in insulin hypoglycemia. A fall in B cell reserves is caused by their functional overtension, destruction and replacement of the pancreatic parenchyma by the connective tissue. The main morphological reason for glucagon release lowering in patients with pronounced obesity is reduction of A cell number. An elevation of somatostatin level in the blood of obese patients with a simultaneous decrease in D cell number in pancreatic islets of experimental animals indicates that this rise is stipulated by intensified hypothalamic somatostatin secretion.

Animals↗