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Biomedical subjects

P Husslein

Publications and source records attributed to P Husslein.

At least 145 records · Page 8Linked to original sources
PubMed1990

[Incidence and therapy of hyperstimulation following local prostaglandin administration for labor induction].

A major cause of concern with respect to local prostaglandin (PG) E2 application is uterine hyperstimulation. The purpose of the present study was to evaluate the incidence of hyperstimulation and the possibility of treating this complication. A total of 181 cases were registered in two obstetric centres over a 51-month period. The rates of hyperstimulation were 7.3% in the group receiving intravaginal PG E 2 tablets (3 mg), 2.9% with intravaginal gel (2.5 mg), and 0.5% with intracervical gel (0.5 mg). In 178 cases (98.3%) the infusion of a beta-2 adrenergic drug (hexoprenaline or terbutaline) led, without adverse effects, to the rapid resolution of the alarming findings. Caesarean section was necessary in 3 patients. Depressed Apgar scores and an umbilical artery pH less than 7.20 were uncommon and, indeed, no more frequent than in PG E 2-treated cases without hyperstimulation. We conclude that uterine hyperstimulation is uncommon after low-dose PG E 2 therapy and is usually rapidly reversible, without apparent untoward intrapartum or neonatal effects.

Adolescent↗
PubMed1990

[Treatment concepts in tubal pregnancy].

The incidence of tubal pregnancy has increased markedly over the past years. Reasons for this are increased infections of and operations on the tubes and also improved diagnosis of the condition. The development of sensitive pregnancy tests, a constant improvement in ultrasound, introduction of laparoscopy and last, but not least, an increase in the degree of awareness amongst the general public have led to a much earlier diagnosis of tubal pregnancies. Therefore, it is possible to treat tubal pregnancies in a more conservative fashion operatively but also medically.

Dinoprost↗
PubMed1990

[Tumor markers and creatine kinase in the differential diagnosis of tubal pregnancy].

In the present study we tried to evaluate the cancer marker CA 19-9, CA 12-5, CA 15-3 as well as the enzyme creatine-kinase (CK) whether they are of any diagnostic value in cases of tubal pregnancies. 15 patients with laporoscopically verified tubal pregnancy were compared with 15 patients with normal intrauterine pregnancies of the same age. Except one case of elevated CK in a patient with tubal pregnancy all other values were within the normal range. We concluded, that tumor markers and CK are inefficient for preoperative differential diagnosis in cases of tubal pregnancies.

Antigens, Tumor-Associated, Carbohydrate↗
PubMed1989

[A new method of treating tubal pregnancy using prostaglandin F2a and E2].

The present paper reports on the treatment of 30 tubal pregnancies verified by laparoscopy by means of intratubal prostaglandin (PG) F2a and systemic PG E2. Tubal pregnancy was successfully treated in 25 patients; three patients exhibited side effects. The comparison with surgical management showed better results concerning the tubal patency in the PG-treated group. Further studies should clarify whether this technically simple procedure is superior to the existing methods.

Chorionic Gonadotropin↗
PubMed1989

Prostaglandin injection for termination of tubal pregnancy: preliminary results.

A variety of conservative surgical techniques is available for the termination of ectopic pregnancy with preservation of the tube. We report on a new treatment by means of intratubal prostaglandin F2 alpha application followed by intramuscular administration of a prostaglandin E2 derivative (sulprostone) for 3 days. Only 5 of the 30 patients enrolled had to undergo laparotomy later. The results were compared with those obtained by different surgical procedures during the 2 preceding years. Hysterosalpingography was performed in 12 patients of the prostaglandin treated group and 14 of the surgically treated group. Tubal patency was demonstrated in 11 patients of the PG group but only in two patients of the surgically treated group.

Abortifacient Agents↗
PubMed1989

Is induction of labor indicated in prolonged pregnancy? Results of a prospective randomised trial.

In 345 women with a favorable cervical score at due date, labor was either induced by means of intravaginal application of tablets containing 3 mg of prostaglandin E2 or spontaneous onset of labor was awaited until the 42nd week of pregnancy. Eighty percent of the nulliparae and 96.3% of the multiparae of the induction group gave birth within 24 h of the administration of the first tablet. All pertinent delivery intervals were significantly shorter in this group compared to those women where spontaneous onset of labor was awaited. The rate of operative deliveries was lower in the induction group. With the exception of 1 fetal death 3 days after due date, fetal outcome was excellent in both groups. Elective induction was at least equivalent to awaiting the onset of spontaneous labor and was not associated with higher complication rates due to the method of induction.

Clinical Trials as Topic↗
PubMed1989

[Conservative treatment of early tubal pregnancy].

Due to improved diagnosis most tubal pregnancies are detected today before tubal rupture. Therefore various conservative treatment modalities have been described lately. In the present study 73 cases of unruptured tubal pregnancies are described that where treated with local and systemic PG application. With an initial beta-hCG level of below 2,500 mIU/ml serum, 45 of 53 cases could be treated successfully without classical operation. With an initial beta-hCG above 2,500 mIU/ml serum the results were less satisfactory. Hysterosalpingography controls showed that almost all pertinent tubes are patent after such treatment.

Abortifacient Agents, Nonsteroidal↗
PubMed1989

[Chorionic biopsy].

Explore the source record for details and available documents.

Chorionic Villi Sampling↗
PubMed1988

[Successful treatment of a tubal pregnancy by local and systemic administration of prostaglandin].

The recent trend towards conservative management of tubal pregnancies, as well as first reports on the efficacy of systemic or local administration of prostaglandins prompted us to investigate the therapeutic effect of PGF2 alpha injected directly into a non-ruptured tubal pregnancy, followed by systemic administration of a synthetic longer-acting PGE 2 derivative for 3 days. Serial determinations of hormone parameters in the follow up of this patient verified that this combination treatment is capable of dealing with tubal pregnancy without further surgical treatment. Hysterosalpingography performed 6 weeks afterwards showed tubal patency on both sides.

Administration, Topical↗
PubMed1988

Prophylactic perioperative use of clindamycin and metronidazole in vaginal hysterectomy without pelvic floor repair.

We studied the effect of perioperative clindamycin (3 x 600 mg in 100 ml 0.9% saline), metronidazole (3 x 500 mg in 100 ml 0.9% saline) and a placebo (3 x 100 ml of 0.9% saline) in 120 patients having a vaginal hysterectomy without colporrhaphy. The rate of postoperative urinary tract infections was significantly higher in the placebo group, but there was no significant difference between the three groups in the days of postoperative fever (a temperature above 37 degrees C) or in the length of hospital stay. One patient on placebo had a vault infection and another had a fever of unknown origin.

Adult↗
PubMed1988

[Treatment of tubal pregnancy by local and systemic administration of prostaglandin. Initial experiences].

The present study reports on the treatment of 6 tubal pregnancies established by laparoscopy intratubal PGF2 alpha injection accompanied PGE2 applied systemically. The method was successful in all cases avoiding the usual surgical procedure. Concerning the side effects one patient exhibited higher postoperative temperature, whilst another showed hypertony and tachycardia immediately after PGF2 alpha injection which lasted a few minutes. Further studies should clarify whether this technically simple procedure is superior to the existing methods.

Corpus Luteum↗