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Biomedical subjects

P Hsu

Publications and source records attributed to P Hsu.

41 records · Page 3Linked to original sources
PubMedDate not supplied

Chief residency in PM&R. A balance of education and administration.

The role of the Physical Medicine and Rehabilitation (PM&R) chief resident (CR) in physiatry residency education programs is the subject of annual deliberation in many academic centers. A national survey of PM&R programs was conducted to determine CR number, selection method, responsibilities, duration of service, and postresidency destiny. The questionnaire generated a response rate of 86% with 90% of programs reporting 1-3 CRs per year. A range of 1-11 CRs were selected annually per program. The most common methods of CR selection were faculty vote (45%), combined resident-faculty vote (22%), and other (33%). The prevalence of administrative responsibilities included orienting new residents (97%), formulating call schedules (92%), dispute mediation (88%), medical student-residency interviews (87%), rotation schedule configuration (64%), faculty meeting participation (61 %), social event promotion (59%), and elective and externship schedule development (31 %). Educational duties included teaching and organizing didactics (87%), organizing pharmaceutical and rehabilitation equipment inservices (77%), arranging didactics (77%), board review coordination (72%), arranging grand round speakers (66%), core curriculum lectures (61%), and facilitating resident research (37%). CR career goals included group practice (48%), academic faculty (29%), solo practice (5%), and fellowship (18%). Overall, PM&R CRs maintain considerable involvement in the educational aspects of residency training, although their clinical and administrative duties predominate. Although the PM&R CRs contribute significantly to the academic growth and development of their respective training programs, only a modest percentage (47%) of CRs choose to remain in academic physiatry via an attending (29%) or fellowship (18%) position.

Academic Medical Centers↗
PubMedDate not supplied

Program optimization: a semi-quantitative approach.

The authors describe a quantitative model used to express the relative costs and benefits of alternative approaches to pulmonary prevention. This approach identifies the factors that a program director must consider in planning preventive interventions for respiratory disease of workers.

Cost-Benefit Analysis↗
PubMedDate not supplied

Reproducibility of LSI HER-2/neu SpectrumOrange and CEP 17 SpectrumGreen Dual Color deoxyribonucleic acid probe kit. For enumeration of gene amplification in paraffin-embedded specimens: a multicenter clinical validation study.

Overexpression and/or amplification of HER-2/neu gene have been found to be prognostic and predictive in breast and other cancers. Fluorescence in situ hybridization (FISH) assay, with its sensitivity and specificity, can be a superior method of detection when its performance characteristics are demonstrated. A multicenter study was initiated to evaluate the reproducibility of the LSI HER-2/neu SpectrumOrange and CEP 17 SpectrumGreen Dual Color DNA Probe for enumeration of both the HER-2/neu gene and chromosome 17 (signals) in interphase cells. Section slides were prepared from four cell lines (H, E, R, and N) with known ratios of the HER-2/neu to CEP 17 copy numbers (approximately H = 1.10, E = 1.70, R = 4.50, N = 9.0). The study variable was the ratios of the HER-2/neu to chromosome 17 copy numbers. Reproducibility with respect to assay, site, lot, day and reader was evaluated at 3 centers. Out of 120 specimen slides, 100 percent were successfully assayed. There were no significant differences among: (1) four repeated assays of the same specimen (p = 0.99), (2) the four probe lots (p = 0.33), or (3) the four study days (p = 0.54). There was statistically significant, but not important differences among centers and between readers. The ratios of the HER-2/neu to chromosome 17 copy numbers were estimated with accuracy and precision; the mean ratios (and sd) for specimens, H, E, R, and N were 1.05 (0.06), 1.81 (0.12), 4.48 (0.28), and 8.60 (1.23), respectively. In summary, assays with the LSI HER-2/neu and CEP 17 Dual Color DNA Probe Kit, conducted at three sites by 6 different technicians, over 8 assay days, using kits from four lots, were performed with a high success rate in paraffin-embedded specimens. The signal enumeration was also accurate and precise. This study demonstrated that the results obtained by using the LSI HER-2/neu SpectrumOrange and CEP 17 SpectrumGreen Dual Color DNA Probe Kit are reliable and reproducible.

Breast Neoplasms↗