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Biomedical subjects

P Hoppe

Publications and source records attributed to P Hoppe.

30 records · Page 2Linked to original sources

An embryonic inducing factor: isolation by high performance liquid chromatography and chemical properties.

A protein (vegetalizing factor) which induces amphibian gastrula ectoderm to tissues which in normal development are derived from endoderm and mesoderm has been isolated from chicken embryo trunks by a combination of size exclusion and reversed phase HPLC. An amount of 0.5 ng factor per gastrula evokes inductions in 80-100% of the cases. The protein (apparent Mr approximately 13 000) is split by NaBH4 to polypeptide chains of about half the size under conditions in which disulfide bridges are reduced. The biological activity is lost.

Amino Acids↗

Effect of certain organic compounds on saliva secretion in sheep.

In two sheep fitted with esophageal cannulas the stimulation of resting saliva secretion by intrabuccal injections of volatile fatty acids (VFA) and of certain organic plant compounds was investigated. Volatile fatty acids, salicin and vanillin increased saliva flow rate by 100, 76 and 72% over 2.5 min after injection. Minor positive or negative effects were obtained with quercitrin, protocatechuic acid, grass juice, anethole and agaricinic acid. Injections of volatile fatty acids and of salicin induced chewing activities, which were significantly correlated with salivary flow rates. The results indicate that organic plant compounds can provide a stimulus for saliva secretion mediated in part by chewing activities.

Animals↗