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Biomedical subjects

P Holt

Publications and source records attributed to P Holt.

At least 73 records · Page 4Linked to original sources
PubMed1985

Placental and fetal pathology in Coxsackie virus A9 infection: a case report.

A 27-year-old patient contracted a Coxsackie virus A9 meningitis at 33 weeks gestational age. Two weeks later a macerated female stillborn infant was delivered. The placenta showed a diffuse perivillous fibrin deposition with villous necrosis and inflammatory cell infiltration and yielded Coxsackie virus A9 on culture. Post-mortem examination of the fetus showed only minimal inflammatory changes in the cardiac connective tissue and the subarachnoid space.

Adult↗
PubMed1985

Effect of exercise on ventricular response to atrial fibrillation in Wolff-Parkinson-White syndrome.

Ten patients with Wolff-Parkinson-White syndrome underwent cardiac electrophysiological study extended to include the induction of atrial fibrillation at maximum exercise in the upright position. This was performed using a new temporary bipolar lead with a helical active fixation tip for atrial pacing. The highest rate of atrioventricular conduction via the accessory pathway was greater during exercise than at rest in all 10 patients (mean increase 28%). In three cases the resulting ventricular rate exceeded 300 beats/min, but no patient had severe symptoms or ventricular arrhythmias. The exercise induced enhancement of accessory pathway conduction may significantly but unpredictably affect the risk from spontaneous atrial fibrillation especially in patients with coronary artery disease or in those taking antiarrhythmic drugs. The test procedure was sufficiently simple and well tolerated to be included in our routine electrophysiological investigation.

Adolescent↗
PubMed1983

Vibrio cholerae hemagglutinin/lectin/protease hydrolyzes fibronectin and ovomucin: F.M. Burnet revisited.

Cholera vibrios produce a single polymeric protein that (i) causes hemagglutination; (ii) appears to participate in their attachment to gut epithelium; (iii) may mediate their detachment from gut epithelium; and (iv) is a protease that hydrolyzes fibronectin and mucin, cleaves lactoferrin, and nicks the A subunit of the choleragen-related heat-labile enterotoxin of Escherichia coli.

Animals↗
PubMed1983

A controlled trial of 'Senokot' in faecal soiling treated by behavioural methods.

A double-blind randomly controlled trial of one particular laxative, Senokot, used in moderate dosage, was carried out on a group of 40 children with severe and persistent soiling and often with a history of faecal retention. Significant improvement occurred following three months of outpatient treatment using a behavioural approach and either Senokot, placebo or no medication. However, there was no evidence either during the trial or subsequently when Senokot was employed to supplement behavioural treatment in every child who continued with therapy that this laxative contributed in any way to relieving the problem in this group of cases.

Behavior Therapy↗
PubMed1983

Parkinson's disease.

Explore the source record for details and available documents.

Activities of Daily Living↗
PubMed1982

High-performance liquid chromatographic measurement of amiodarone and its desethyl metabolite: methodology and preliminary observations.

A high-performance liquid chromatographic technique is described for the measurement of amiodarone and its desethyl metabolite in plasma. Preliminary observations are presented on the concentrations of metabolite found during the early stages of chronic amiodarone therapy. A case history is outlined in which noncompliance during treatment with amiodarone was confirmed by measurement of the ratio of desethylamiodarone to amiodarone concentrations.

Amiodarone↗
PubMed1982

Involvement of immune mechanisms in the pathogenesis of rosacea.

Twenty-five patients with rosacea were compared with twenty-five control subjects for previous medical history and tests of immune function. Rosacea patients were found to have a higher incidence of disorders of the auto-immune type and were significantly more difficult to sensitize to DNCB than the controls. In addition, twelve of the rosacea patients and eleven other rosacea patients had biopsies which were examined by the direct immunofluorescence technique. In only five was the test negative. In the remainder deposits of IgM and/or IgG and/or complement were found at the dermo-epidermal junction and/or in the dermal collagen. Serum from the rosacea patients was also examined by the indirect technique and in six cases a circulating antinuclear antibody of IgM type was found. It is suggested that altered immune function plays a significant role in the pathogenesis of the disease.

Adult↗
PubMed1981

Immune complexes in early arthritis. L Detection of immune complexes before rheumatoid arthritis is definite.

Fifty-three patients with early arthritis were studied longitudinally for up to 3 years. During this time, 24 developed sufficient features for definite rheumatoid arthritis (RA) to be diagnosed. The other (arthralgia patients) differed from the RA patients as, in the majority, C-reactive protein and ESR were normal and anti-nuclear antibodies or rheumatoid factors were rarely found. Moreover, in time their signs and symptoms improved or disappeared. Circulating immune complexes were detected in both groups of patients by the platelet aggregation test whereas complexes detected by abnormal Clq-binding activity were found mainly in the RA patients. Platelet-aggregating complexes were usually present in the first samples studied and disappeared in the arthralgia patients with recovery from their symptoms. In the RA patients, Clq-binding complexes appeared simultaneously or later than platelet-aggregating complexes but both tests were positive several months before RA could be diagnosed. These results suggest that immune complexes are one of the first immunological abnormalities to appear in patients with arthritis. Although the constituent antigen and antibody of complexes detected by either test are unknown, their possible nature is discussed.

Adolescent↗
PubMed1976

Pemphigus in a patient treated with penicillamine for generalized morphea.

A 56-year-old woman with generalized morphea was treated with penicillamine. Four months after commencing treatment, she developed an eruption clinically, histologically, and immunopathologically consistent with pemphigus. The eruption disappeared following withdrawal of the drug. It is suggested that penicillamine initiated epidermal damage.

Drug Eruptions↗