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Biomedical subjects

P Holstein

Publications and source records attributed to P Holstein.

At least 73 records · Page 4Linked to original sources
PubMed1976

Intra-arterial infusion of prostaglandin E1 in normal subjects and patients with peripheral arterial disease.

Acute vasodilatation was produced by infusion of prostaglandin E1 (PGE1) in the femoral artery in 6 patients with occlusive arterial disease of the legs and in 3 normal subjects. The effect on blood flow and on blood pressure was measured at different segments of the leg with the strain gauge technique, isotope clearance technique, and photoelectric technique. Skin temperature was measured at different levels by using thermocouples. The blood pressure on the legs decreased at all segments during vasodilatation as well in patients as in controls. The blood flow increased in all segments in normal controls. In patients the blood flow increased proximally in the legs. Distally, however, no increase could be demonstrated. As a good effect of PGE1, on ischaemic rest pains has been reported, mechanisms other than vasodilatation should probably be considered.

Adult↗
PubMed1976

Decompression with the aid of insoles in the treatment of diabetic neuropathic ulcers.

Thirty-seven out of 38 neuropathic ulcers in 21 diabetic patients healed during relief of external pressure obtained by properly fitted interchangeable insoles. The time required for healing was 1 to 12 months (mean 3.6 months). The presence of mild occlussive arterial disease did not influence the course of healing. Gross infection, which occurred in eight patients could be controlled by immobilization, antibiotics and, in the presence of pus, by radical surgical drainage.

Aged↗
PubMed1975

A long term follow-up of Moore arthroplasty in femoral neck fractures.

Moore arthroplasty was performed for medial femoral neck fractures in 169 patients. The mortality rate was 21.3 per cent within 3 months. The general postoperative complication rate (39.6 per cent) was dominated by cardiopulmonary (17.2 per cent) and thromboembolic (16.0 per cent) events. Of local complications, wound infection was found in 4.7 per cent and osteitis in 3.0 per cent of cases. A total of 60 patients were followed up with a mean observation time of 4.9 years. Of these, 8.3 per cent sustained femoral fractures during this period. The results classified according to the criteria of the American Academy of Orthopedic Surgeons showed 52 per cent excellent or good, 43 per cent fair and 5 per cent poor results. The roentgenological finding of settling or osteolysis along the prosthesis was significantly correlated to reduced hip mobility. Ossification in the prosthetic fenestres gave significantly diminished settling, and was correlated to better hip mobility and less pain. In our opinion, Moore arthroplasty has proved to be an acceptable method for the treatment of femoral neck fractures in elderly patients, as 73 per cent had an acceptable range of motion, 40 per cent managed walking distances of more than 500 m and 70 per cent had minimal or no pain. Although 25 per cent became nursing home patients, this reduction of vitality could be related to the hip arthroplasty in only two cases.

Aged↗
PubMed1975

Functional results after Moore arthroplasty in femoral neck fractures. A long-term follow-up study.

Sixty patients with Moore's hip arthroplasty were followed with a mean observation time of 4.9 years. The results were found to be acceptable, as 70% had minimal or no pain, 78% had acceptable hip mobility and 40% were able to walk more than 500 metres. 25% became nursing-home patients, but in nearly all of these cases this was due to unrelated disabling illnesses. According to the classification adopted by the American Academy of Orthopedic Surgeons, 52% were classified as excellent or good, 43% as fair, and 5% as poor. The roentgenological findings of setting of the prosthesis and osteolysis along the prosthesis were significantly correlated to reduced hip mobility.

Aged↗