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Biomedical subjects

P Holma

Publications and source records attributed to P Holma.

28 records · Page 2Linked to original sources
PubMed1977

Effect of an anabolic steroid (metandienone) on central and peripheral blood flow in well-trained male athletes.

Several haemodynamic variables were measured in sixteen well-trained athletes at rest and during muscular exercise before and after two months of a daily oral dose of 15 mg of metandienone, an anabolic steroid (17alpha-methyl-17beta-hydroxy-1,4-androstadien-3-one). Their training programmes were the same as they had been for at least three years before the study. During metandienone treatment the total blood volume increased by about 15%, and the heart rate decreased significantly both at rest and during exercise. The resting values of cardiac index and stroke index did not differ significantly, while during muscular exercise cardiac index showed a tendency to increase, and stroke index increased by 20% during the treatment period. When treatment was discontinued, the haemodynamic values returned to pre-medication levels, and when a repetition of the treatment was carried out, exactly the same changes were seen. The resting forearm blood flow did not differ significantly during the treatment, while the peak flow during post-ischaemic hyperaemia increased by 27%. The pulmonary blood volume, peripheral resistance and mean arterial pressure did not differ significantly after metandienone treatment. The mean body weight increased significantly during the treatment period.

Administration, Oral↗
PubMed1976

Effect of an anabolic steroid (metandienon) on plasma LH-FSH, and testosterone and on the response to intravenous administration of LRH.

Plasma levels of testosterone, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) as well as the response of LH and FSH to the intravenous administration of 100 mug of luteinizing hormone releasing hormone (LRH) were measured in 16 well-trained athletes (mean age 30 years) before and after 2 months of daily oral intake of 15 mg of metandienon, and anabolic steroid (Anabolin, 17 alpha-methyl-17beta-hydroxy-1,4-androstadien-3-one, Medica, Finland). All athletes continued to train regularly, just as they had done for several years. During administration of metandienon the mean plasma testosterone level fell 69%, from 29.4 +/- 11.6 nmol/1 to 9.1 +/- 7.5 nmol/1. The mean plasma levels of LH and FSH also fell significantly (P less than 0.001 and P less than 0.01, respectively), both about 50%. Because LH and FSH levels were low after administration of the steroid the maximum stimulation values after LRH administration were also lower than pre-treatment values although the mean increments did not differ significantly before and after administration of the anabolic steroid. However, after treatment, the FSH response curve had a biphasic pattern in most subjects, with peaks at 10 to 20 and 50 to 60 min after the iv injection of LRH. Administration of LRH after the treatment period had no effect on FSH secretion in two subjects and no effect on LH secretion in one. Our results show that administration of an anabolic steroid causes a pronounced lowering of plasma levels of testosterone, LH and FSH but causes no gross alteration in the response of LH secretion to stimulation by LRH. The reason for the biphasic response pattern of FSH to LRH administration in most subjects is not known.

Adult↗
PubMed1976

Haemodynamic effects produced by insufflation of carbon dioxide into the abdominal cavity during laparoscopy.

Nine healthy women underwent diagnostic laparoscopy during balanced anaesthesia without halothane. Heart rate, blood pressure and cardiac output were measured before and after insufflation of carbon dioxide in to the abdominal cavity. The cardiac output was measured by a bedside radiocardiographic apparatus using 113Indium as a tracer. There was remarkable stability of the cardiovascular system during laparoscopy with only slight rise in blood pressure.

Abdomen↗
PubMed1976

Long-term contraception with norethindrone subcutaneous capsules.

Norethindrone (NET) contained in silicone rubber, for slow release, was implanted subcutaneously. The rate of release of NET was 10-12 mug/day/10 mm length of the silicone rubber. The total length of the implants used varied from 100 mm to 200 mm. During the whole observation time 562 women months, 14 a-cidental pregnancies occurred. The pregnancy rate decreased with increasing length of implants. The implants produced a transient ovulation suppression, which subsided in four to five cycles. The plasma levels of NET stabilized at a level which was less than that reached by daily oral administration of 350 mug of NET. The high pregnancy rate and the great number of implants required render the method impractical for contraception. However, the active life-span of implants is three years and because there were few minor side-effects, the method was well accepted.

Contraception↗