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Biomedical subjects

P Hirsbrunner

Publications and source records attributed to P Hirsbrunner.

8 recordsLinked to original sources
PubMed1994

Allergic contact dermatitis from ethyl chloride and sensitization to dichlorodifluoromethane (CFC 12).

Despite the widespread use of ethyl chloride as a local anesthetic and chlorofluorocarbons as propellants in medical and cosmetic aerosols, contact allergy to these 2 gases is rare. In a 30-year-old woman, an unusual itchy dermatitis appeared at all skin sites where a medical aerosol containing ethyl chloride had been briefly applied. Subsequent re-exposure to the spray and patch tests revealed contact sensitization to ethyl chloride and dichlorodifluoromethane (CFC 12). Histologic and immunohistochemical examinations of the test reaction were consistent with a T-cell-mediated allergic reaction. The low incidence of contact allergy to ethyl chloride and chlorofluorocarbons may be due to the rapid evaporation of these volatile gases, thus preventing intense and prolonged contact with the skin and consequently contact sensitization. A modified patch test procedure using perforated plastic chambers to allow gas evaporation is necessary to test volatile agents.

Adult↗
PubMed1992

Lichen planus: an unusual cause of phimosis.

We report on a 47-year-old man with oral and genital lichen planus. After some months of the disease, increasing phimosis developed which had not been present before. Retraction of the foreskin was now impossible and sexual intercourse was painful. Treatment with triamcinoloneacetonide and etretinate ameliorated the phimosis but the patient was still not comfortable and circumcision was performed. Histology from the foreskin revealed the typical picture of lichen planus. No features of lichen sclerosus et atrophicus were present. This is the first published observation of phimosis as a result of lichen planus.

Humans↗
PubMed1992

[Ross syndrome].

We report on a 25-year-old patient with hyporeflexia, progressive segmental hypohidrosis and dry, scaly skin mimicking tinea manuum on the affected palm. This case is the fourth with Ross syndrome and skin manifestations as a result of segmental hypohidrosis.

Adult↗
PubMed1991

Kahweol and cafestol: inhibitors of hamster buccal pouch carcinogenesis.

Kahweol and cafestol, two compounds extracted from green coffee beans, were tested for cancer chemopreventive activity. For the experiment, 60 hamsters were divided into three equal groups and placed on one of three diets. The animals in Group I received a normal diet, whereas the animals in Groups II and III received the same diet supplemented with a 50:50 mixture of kahweol and cafestol. The content of the kahweol and cafestol mixture in these two diets was 0.2 g/kg of food (Group II) and 2.0 g/kg of food (Group III). After the hamsters adjusted to their respective diets, 16 hamsters from each group were selected. The left buccal pouches of these animals were painted three times weekly with a 0.5% solution of 7,12-dimethylbenz[a]anthracene (DMBA) in mineral oil. The 12 remaining hamsters were used as controls. The left buccal pouches of these animals were painted three times weekly with mineral oil. After 13 weeks (39 applications) the hamsters were killed. Multiple tumors were common in animals treated with DMBA; however, the animals receiving kahweol and cafestol in the diet (2 g/kg of food) exhibited a 35% reduction in tumor burden. Further comparisons between Groups I and III showed that this reduction in tumor burden was due to a decrease in tumor number. The results for Group II were inconclusive. Some reduction in tumor number was found, but this was offset by an increase in the size of the tumors.

Animals↗
PubMedDate not supplied

Allergic contact dermatitis from tixocortol pivalate in a nasal spray masquerading as infectious complication of sinusitis.

Allergic contact dermatitis to corticosteroids is not uncommon and is increasingly reported. Contact allergy to nasal corticosteroids is rare and may present with atypical symptoms, which may be confused with infectious complications. We report on a patient in whom the misinterpretation of her allergic nasal symptoms to the corticosteroid tixocortol pivalate resulted in hospitalization and considerable medical expenses.

Adult↗