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Biomedical subjects

P Hermann

Publications and source records attributed to P Hermann.

At least 73 records · Page 4Linked to original sources
PubMed1978

Spurious brain creatine kinase in serum from patients with renal disease.

Creatine kinase isoenzyme I(BB) is generally not detectable in normal serum, and its occurrence in serum has been documented in only a few disease states. In particular, increased activity of this isoenzyme has been reported in association with chronic renal failure, hemodialysis, and renal transplantation. The present study demonstrates that the apparent creatine kinase observed in the serum of such renal patients is an artifact, observed as a result of measuring creatine kinase isoenzymes by fluorescence. Our observations resemble those of McKenzie et al. [Clin. Chim. Acta 70, 333(1976)] concerning an artifact in the fluorometric determination of lactate dehydrogenase isoenzymes in the sera of patients with end-stage renal failure. The artifact binds to albumin, is not a protein, and occurs in some normal sera at very low concentrations. This artifact can be mistakenly identified as isoenzyme I in renal-disease patients if CK isoenzymes are determined fluorometrically.

Brain↗
PubMed1977

The role of the AT pairs in the acid denaturation of DNA.

It has been determined previously that the protonation of the GC pairs induces a DNA conformation change which leads to a "metastable" structure. The role of the AT pairs, however, is no well known because the protonation does not modify their spectral properties. By means of an indirect method based on the binding of proflavine, it has been determined that the AT pairs are protonated before the acid-induced denaturation and that they seem to be unable to assume a conformation change when protonated. These results would indicate that the protonated AT pairs may be responsible for the induction of the acid denaturation and not the GC pairs as it was thought previously.

Adenine↗
PubMed1975

[Contribution to the study of students' mental health (author's transl)].

The authors intended to study within the population of an outpatient psychiatric consultation those who are under training or education, whatever type of education it may be. These 'students', in a broad sense, have been the object of epidemiological and clinical studies. The sample they constitue has been compared first with a sample of the service's population, secondly within the sample itself comparison has been made between smaller groups, caracterized by the level of formation. This leads to a description of the typical 'student patient' of this consultation. The comparison with the other patients of the service shows some differences, specially age. Students are. as a rule, younger. We note others and more interesting differences related with origin, the proportion of strangers is much greater in the students; group. On the other hand, they are people who spontaneously come to consult for neurosis. The comparison between the two sub-groups within the group of students shows the same differences we noticed above. They showed up with a greater evidence in the University students' group, but this last group does not fundamentally diverge from the students in the professional schools in relation to the items that were the object of this study.

Adolescent↗