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P Hermanek

Publications and source records attributed to P Hermanek.

At least 109 records · Page 6Linked to original sources
PubMed1991

[Oncologic surgery/pathologic-anatomic viewpoint].

Important progress achieved during the last years in four fields is reported: (1) Preoperative histological diagnosis: use of immunohistology, improvements by the 2nd edition of the WHO International Histological Classification of Tumors; (2) pathology of lymphatic spread: detailed classification according to topography and number of involved nodes, increased knowledge of factors influencing lymphatic spread and standardization of examination methods with statements on the number of examined and involved nodes; (3) publication and worldwide acceptance of the uniform 4th edition of the TNM Classification; and (4) introduction of the residual tumor (R) classification.

Breast Neoplasms↗
PubMed1991

Staging of exocrine pancreatic carcinoma.

After many years of attempting to stage exocrine pancreatic carcinoma, the fourth edition of the UICC TNM Classification of Tumours is now the international uniform system; it has been accepted by all national TNM committees. The TNM/pTNM-defined stage grouping is complemented by the R classification, which describes the presence or absence of residual tumour following treatment. With this, it is possible to make a good assessment of the prognosis following resection of ductal adenocarcinoma. Multivariate studies must definitively clarify whether additional parameters are of significance for prognosis. A further subdivision of Category pN1 into pN1a (metastasis in single node) and pN1b (two or more nodes) is recommended.

Carcinoma↗
PubMed1991

Surgical treatment of ductal pancreatic carcinoma.

Among 587 patients with ductal pancreatic carcinoma who were examined between 1969 and 1987, 260 (44.3%) had distant metastases at the time of diagnosis. Tumour resections, mostly subtotal duodenopancreatectomies, were performed in 138 patients (23.5% of all patients, or 39.8% of all patients without distant metastases); in 91 patients the resection was for cure (R0). Operative mortality following tumour resection was 6% for all patients. The age-corrected 5-year survival rate was 2.9% for all patients and 16% where the resection was curative; of these 46% were in Stages I and II and 6% in Stage III. In non-curative resections, the median survival time was 7.2 months, which was significantly longer than the 3.4 months following bypass operation. Cure for pancreatic carcinoma can be achieved only through surgery, and a negative attitude towards surgery must be resisted.

Carcinoma↗
PubMed1990

Prognostic grouping: the next step in tumor classification.

At present, staging of malignant tumors is based on the anatomical extent of disease defined by the T(umor) N(odes) M(etastasis) classification. The main objective of further efforts in classifying tumors is to identify additional independent prognostic factors and to create mathematical models that may predict disease progression by prognostic grouping. This article summarizes problems, methods and the design of coordinated studies on prognostic grouping.

Classification↗
PubMed1990

Intraoperative spillage of tumor cells in surgery for rectal cancer.

Inadvertent perforation or incision into rectal carcinoma during surgery may lead to massive dissemination of tumor cells in the operative area. It was observed in 8.7 percent of 1360 radical resections for cure. In time, the incidence could be reduced from 11.0 to 5.2 percent. Intraoperative spillage of tumor cells influences the incidence of local recurrence. In the last period (1982 to 1985) in cases of spillage of tumor cells, local recurrence was seen in 39 percent as opposed to 12.9 percent in perforation or incision of the tumor. Intraoperative tumor-cell spillage has a negative effect on survival rates, reducing the relative five-year survival rate after resection for cure from 70 to 44 percent. It should be recorded in the surgical and pathologic reports and considered in the analysis of treatment results and in selection of patients for adjuvant radiotherapy.

Humans↗
PubMed1990

Evaluation of the new tumor, nodes and metastases classification of renal cell carcinoma.

The predictive strengths of the third and new fourth editions of the tumor, nodes and metastasis classification are compared using 872 cases of operatively treated renal cell carcinoma. The new tumor, nodes and metastasis classification facilitates an improved assessment of prognosis by subdivision of the former category pT3 into pT3a and pT3b. The new pN classification permits recognition of an especially unfavorable subgroup (pN3) in patients with regional lymph node metastases. The new stage grouping makes a rough subdivision of patients into groups with different prognoses. However, stages 1 and 2 show similar survival rates. Compared to the commonly used Robson stages, the International Union Against Cancer stage grouping has advantages as well as disadvantages. Any resulting recommendations for modification of stages should be subject to testing by other institutions.

Carcinoma, Renal Cell↗
PubMed1990

[Discontinuity resection of the colon. Indications and results].

In 83 patients discontinuity resection of the colon was performed. Due to negative selection factors postoperative mortality was 26.5%. In 37 patients continuity of the colon was restored, no patient died postoperatively. The only severe complication was formation of a colovesical fistula requiring a pull-through operation.

Adolescent↗
PubMed1989

[Tumor classification--present status and further developments].

Characterization of the individuality of a malignant tumor is needed for planning treatment and evaluating its results. The present classification of tumors is the result of long years of international effort, and is published as the WHO International Histological Classification of Tumors and the UICC TNM Classification of Malignant Tumors, 4th edition. For a number of tumor entities TNM classification is not yet available. A classification of liver and lung metastases is the aim of UICC studies, some of which have been initiated. The further development of tumor classification is focused on the identification of independent prognostic factors (prognostic indices and prognostic grouping), which apart from the TNM defined stage, have separate influence on the prognosis.

Humans↗