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Biomedical subjects

P Hedner

Publications and source records attributed to P Hedner.

At least 73 records · Page 4Linked to original sources
PubMed1977

Inhibition by somatostatin of mouse thyroid activity following stimulation by thyrotrophin, isoprenaline and dibutyryl cyclic-AMP.

The recent discovery of somatostatin-containing cells within the thyroid gland infers that somatostatin may influence thyroid activity. This possibility was investigated by measurements of radio-iodine release in mice pre-treated with 125I and T4. The animals were treated with TSH, isoprenaline or dibutyryl-cyclic AMP with and without concomitant injection of somatostatin. It was found that somatostatin reduced the blood 125I increase in response to each of the three thyroid-stimulating agents. The elimination rates of 125I-labelled T4 and T3 were unaffected by somatostatin. The observations suggests that somatostatin may participate in the regulation of thyroid hormone secretion, by an inhibitory effect exerted within the thyroid gland.

Animals↗
PubMed1976

Mechanical and metabolic effects of beta-receptor stimulators, the C-terminal octapeptide of cholecystokinin, and prostaglandin E2 on the isolated, depolarized sphincter of Oddi.

Similar to their actions on normally polarized, isolated sphincter of Oddi, the beta-receptor stimulators isoprenaline and tebutaline, and prostaglandin E2 produced relaxation of the depolarized preparation. The relaxation was accompained by an increase in the intracellular content of cyclic AMP. In contrast to its relaxing effect on normally polarized sphincter preparations, the C-terminal octapeptide of cholecystokinin (C8-CCK) contracted or had no effect on the depolarized sphincter. There was no change or a small decrease in the content of cyclic AMP in the muscle. It is suggested that the relaxing effects of beta-receptor stimulators and prostaglandin E2 on isolated sphinceter of Oddi, and the simultaneous increase in cyclic AMP-content are mediated processes independent of the electrical acitivty of the membrane. However, C8-CCK mediated relaxation and increase in cyclic AMP is dependent on the membrane potential.

Ampulla of Vater↗
PubMed1975

Superior mesenteric angiography and blood flow following intra-arterial injection of prostaglandin F2alpha.

The effect of intra-arterially administered prostaglandin F2alpha(PGF2alpha) on venous demonstration in angiography of the superior mesenteric artery was compared to that of bradykinin in 10 patients, and the flow increase in this vessel following PGF2alpha was measured by a dye dilution technique in another 8 patients. The angiographic demonstration of veins was similarly improved by the 2 drugs, the effect of 60 mug. of PGF2alpha being roughly equivalent to that of 10 mug. of bradykinin. The loss of arterial detail was less marked after PGF2alpha which, however, had a longer duration of action. The flow studies indicated that 80 mug. of PGF2alpha increased the superior mesenteric blood flow 103 +/- 16 per cent. There was no influecne on blood pressure or pulse rate. The patients experienced a sensation of warmth in the abdomen for a few seconds following the injection of drugs, but no other side effect was noted. It is concluded that PGF2alpha causes a rapid increase of the superior mesenteric blood flow in man making it suitable for pharmacoangiography of this vascular bed.

Adult↗
PubMed1975

Pancreatic glucagon response to an ordinary meal.

Glucagon concentrations in the portal and peripheral venous blood were measured in 3 patients after an ordinary meal. A brief increase in glucagon concentration was found in the portal blood but not in the peripheral blood. As the glucose concentrations rose, the glucagon levels fell. The secretion of pancreatic glucagon therefore seems to depend largely on the blood glucose level.

Blood Glucose↗