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Biomedical subjects

P Hausner

Publications and source records attributed to P Hausner.

At least 55 records · Page 3Linked to original sources
PubMed1984

The growth of lymphocyte colonies from peripheral blood of patients with malignant melanoma.

Lymphocytes from the peripheral blood of patients with malignant melanoma were cultivated using a modification of the two-layered cultivation method in a semisolid medium. The ability of the cultivated lymphocytes to form colonies and clusters in agar after stimulation with phytohemagglutinin was compared with the actual clinical state of patients. In patients with malignant melanoma, who show clinical signs of progress, significantly less colonies and clusters are formed than in controls. The number of colonies appears to be a more sensitive sign than the number of clusters. For orientation in clinical practice the number of large colonies is of an importance.

Cells, Cultured↗
PubMed1982

Management of advanced Hodgkin's disease in remission.

Patients with Hodgkin's disease (stage IIIB and IV) after being rendered with combination chemotherapy disease-free, were alternatively allocated to either a group receiving levamisole treatment (Decaris) or to a control group receiving no further therapy until there was evidence of recurrent disease. Laboratory examinations showed that impaired cell mediated immune responses found after termination of intensive chemotherapy were favourably influenced by levamisole treatment. In addition, the duration of remission seems to be longer in the levamisole treated group, although the limited number of patients in the study do not allow a definite conclusions to be drawn.

Cell Migration Inhibition↗
PubMed1981

Changes in skeleton, bone marrow reactivity and in immunity of patients with tumors of testis during long-term complete clinical remission.

A series of various tests were carried out in 19 patients treated for germinal tumors of the testis, with a long-term survival rate (7 to 28 years) in a complete clinical remission and the results compared with those of a previous investigation made 6 years earlier [3]. The tests involved: radionuclear investigation of the skeleton (85Sr--test), determination of bone isoenzyme of serum alkaline phosphatase, urinary hydroxyproline excretion, cytological examination of bone marrow, assay of serum levels of IgM, IgG and IgA as also of C3 complement, determination of the percentage and absolute number of peripheral T-lymphocytes, the test of blastic lymphocyte transformation after PHA and the skin test with DNCB. A chronic restructuralization of bone tissue (positive and suspected 85Sr-test in 74% of patients) was noted even after the relatively long time span. Likewise, an enhanced activity of bone isoenzyme of serum alkaline phosphatase was found in the majority of the patients, as also nonspecific reactive changes of bone marrow in the form of total hyperplasia and hyperplasia of various cellular elements, particularly of plasmacytes, eosinophils and lymphoid reticulum. Immunological tests revealed a depressed cell-mediated immunity -- especially a significant drop in the absolute number of peripheral T-lymphocytes.

Adult↗
PubMed1979

Macrophage electrophoretic mobility test as sensitive probe of transplantation immunity in mice.

Transplantation immunity was examined in mouse H-2- and non-H-2-disparate strain combinations by the macrophage electrophoretic mobility (MEM) assay. Lymph node cells from the recipients rejecting histoincompatible skin grafts were incubated in the presence of solubilized histocompatibility antigens prepared from spleens of the grafts donors. Product(s) of lymphocyte-antigen interaction in appropriate combinations (sensitized lymphocytes with the sensitizing antigen) significantly diminished the electrophoretic mobility of guinea pig macrophages in all of the histoincompatible strain combinations examined. The data indicate that transplantation immunity in mice can be detected by the MEM assay.

Animals↗