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Biomedical subjects

P Hart

Publications and source records attributed to P Hart.

At least 55 records · Page 3Linked to original sources
PubMed1986

Increased resistance to penicillin of oral viridans streptococci in dental students.

Salivary samples were taken annually in October from 48 dental students as they progressed from pre-clinical studies to final year. The MICs of penicillin for the viridans streptococci were determined. Over the three years these organisms became progressively more resistant but not to a level of clinical significance. The findings were confirmed by a cross-sectional study of 57 pre-clinical and 37 final year students. The increase in resistance might have been related to age, but a further study of 20 postgraduate chemistry students of the same age as the final year dental students showed that the former had a population of streptococci similar to that found in the pre-clinical students. Whether the increase in resistance is a result of the dental students working in the clinic or having penicillin more frequently prescribed for them personally is a matter for speculation.

Adult↗
PubMed1986

The effect of a single large dose of amoxycillin on oral streptococci.

Salivary samples were examined for a period three weeks before, and three weeks after the administration of 3 g of amoxycillin in ten volunteers. There was a marked drop in the concentration of streptococci in all subjects in the first 4 h but most had substantially recovered within 48 h. All had recovered at seven days. No strains were resistant to 1 mg/l amoxycillin in the pre-treatment control series, and no resistant streptococci emerged.

Amoxicillin↗
PubMed1983

First-trimester rudimentary horn pregnancy: prerupture ultrasound diagnosis.

A case of pregnancy in the rudimentary horn of a bicornuate uterus is presented, and a discussion of this rare and potentially catastrophic phenomenon follows. This is the first such case reported in which the diagnosis was made early in gestation through the use of ultrasonography. An extrauterine gestation accompanied by a well-defined placenta visible on ultrasound scan is suggested as a criterion for differentiating rudimentary horn pregnancy from abdominal pregnancy.

Adolescent↗
PubMed1981

Atrial septal aneurysm: a cause for midsystolic click. Report of a case and review of the literature.

A patient who was evaluated for a midsystolic click was found to have an aneurysm of the atrial septum as an isolated anomaly. Bulging of this aneurysm into the right atrium was associated with the production of the click. Echo-, phono-, and angiocardiographic features are presented, with a review of the literature on atrial septal aneurysms. These aneurysms, although rare, should be considered in the differential diagnosis of patients with midsystolic click.

Adult↗
PubMed1980

Antigen-dependent physical interaction between human monocytes and T lymphocytes.

The physical interaction between human monocytes and autologous T lymphocytes was studied in cultures of cells from tuberculin-sensitive individuals to which purified protein derivative of tuberculin had been added. Such cultures displayed formation of cell aggregates, each typically consisting of one or two monocytes to which several lymphocytes adhered by means of uropods. The capacity of monocyte-T-lymphocyte mixtures to produce this type of aggregate in response to tuberculin correlated with the tuberculin sensitivity of the cell donor as measured by skin test.

Adolescent↗
PubMed1978

Drug metabolism in liver disease. Identification of patients with impaired hepatic drug metabolism.

Antipyrine half-life (AP t1/2) was measured in 62 patients with, and 10 control patients without, liver disease to ascertain possible factors which may be useful in identifying patients with abnormal drug metabolism. Antipyrine metabolism was normal or marginally impaired in patients with compensated cirrhosis or acute hepatitis, whereas it was frequently abnormal in those with chronic active hepatitis or advanced alcoholic liver disease. A high degree of correlation was found among AP t1/2 and prothrombin time, hepatic encephalopathy, and ascites. Of patients with severely impaired drug metabolism, 80% had one or more of these features. The severity of histological changes in liver biopsies was of additional help in predicting impaired drug metabolism. Concurrent drug ingestion enhanced antipyrine metabolism in most patients with liver disease as well as in control patients. Inadequate diet was associated with prolongation of AP t1/2, but other environmental factors such as alcohol ingestion, cigarette smoking, and coffee consumption did not affect rates of drug metabolism in patients with liver disease. Consideration of all of the above factors allows qualitative predictions of the rate of hepatic drug metabolism in patients with liver disease, as assessed by the AP t1/2.

Acute Disease↗
PubMed1976

Enhanced drug metabolism in cigarette smokers.

The effect of cigarette smoking on salivary antipyrine disappearance rate, and as an index of hepatic drug metabolism, was studied in 42 healthy subjects. Antipyrine half life was significantly shorter in smokers compared with non-smokers. To determine whether this difference was due solely to tobacco consumption eight subjects were restudied two months after they stopped smoking. The mean antipyrine disappearance rate in this group increased by 23% in contrast to that of a control group, which did not alter. Cigarette smoking contributes to the considerable variation in interindividual rates of drug metabolism.

Adolescent↗
PubMed1976

Echocardiographic criteria of normal left atrial size in adults.

Although the measurement of left atrial diameter (LAD) is a standard part of any echocardiographic examination, the normal range for adults has never been well established or correlated with body surface area (BSA) and sex. We studied 100 males and 100 females whose ages ranged from 15 to 70 years, with no evidence of mitral value disease or other form of heart disease which might cause left atrial enlargement. All measurements were obtained between the external surface of posterior aortic root (AR) and the internal surface of the left atrial wall and were recorded at ventricular end diastole (ED) as well as end systole (ES). The LAD at ED ranged from 9.5 to 29.5 mm with a mean of 19 mm +/- 5.0 S.D.; the diameter at ES ranged from 18.3 mm to 38.7 mm with a mean of 28.5 mm +/- 5.1 S.D. The mean LAD at ED was 20.7 mm +/- 4.8 S.D. in makes compared to the mean diameter of 18.3 +/- 4.9 S.D. in females which represents a significant difference (p less than 0.001). The LAD did not correlate with BSA. The left atrial dimension by ultrasound in these 200 normal patients was compared with the same measurement in 50 catheterized patients with mitral valve disease and proven left atrial enlargement. When absolute values of the left atrial dimension both at end systole and end diastole were determined by ultrasound, there was a clear separation between normal and abnormal (p less than 0.001).

Adolescent↗