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Biomedical subjects

P Harris

Publications and source records attributed to P Harris.

At least 325 records · Page 18Linked to original sources
PubMed1978

Current results with construction and interruption of the Waterston anastomosis.

The Waterston anastomosis was constructed in 21 infants and neonates between 1973 and 1977. Sixteen neonates were 1 week old or less and 8 were less than 24 hours old. There were 2 operative deaths, giving a hospital survival of 90%. There were 3 late deaths. All surviving infants received satisfactory palliation except 1 who required a Potts anastomosis one year later. During the same time interval, 9 other patients who had had a Waterston anastomosis underwent complete intracardiac repair. Seven of them had significant angulation of the right pulmonary artery necessitating patch reconstruction. All patients survived operation, and follow-up pulmonary angiograms demonstrated only a slight persistent narrowing of the right pulmonary artery in 2 patients. We conclude that the Waterston anastomosis can be constructed with a low operative mortality even in the severely cyanotic neonate and that it can be taken down at the time of complete repair with minimal morbidity and no mortality even if it has significantly angulated the right pulmonary artery.

Aorta↗
PubMed1978

Simpson-Edinburgh low-pressure air bed: an early clinical evaluation.

A simple, inexpensive low-pressure air bed has been developed for use in situations where decubitus ulcers may arise. This bed is currently being evaluated in patients with spinal injuries, both in the hospital situation and in the home. Early experience is highly encouraging as regular turning of the patient can be safely omitted. We feel that widespread use of this bed could greatly decrease the incidence of pressure sores.

Beds↗
PubMed1978

Myocardial collagen, the effects of right ventricular hypertrophy and its involution induced by changes in atmospheric pressure.

Right ventricular hypertrophy induced by hypobaric conditions was accompanied by an increased collagen mass. Left ventricular collagen was unaffected. Right ventricular mass remained unchanged after involution of right ventricular hypertrophy on return to normobaric conditions. Dietary restriction limited the size and collagen mass of both ventricles.

Animals↗
PubMed1978

Surgical techniques for the serial sampling of cerebrospinal fluid and for electrocorticography in cattle.

During the investigation of a familial neurological disease of cattle with some similarities to human epilepsy serial sampling of lateral ventricular and cisternal cerebrospinal fluid and of electrocortical activity was undertaken. In this paper the surgical approach, the technical problems encountered and some solutions are discussed. Further possibilities for the development and application of the technique are indicated.

Animals↗
PubMed1977

A comparison of the uptake of [1-14C]palmitate into cell fractions of the perfused toad, chick and guinea-pig heart.

1. The incorporation and washout of [1-14C]palmitate in the subcellular fractions of toad, chick and guinea-pig hearts has been studied at warm and cold temperatures. 2. Maximal FFA radioactivity generally occurred in the microsomal fraction. Washout of radioactivity in chick and guinea-pig hearts virtually ceased in the cold, while in the toad it was only moderately affected. 3. The microsomal esterification process was temperature dependent. It was most active in the guinea-pig and least active in the toad.

Animals↗
PubMed1977

Cervical spine stenosis.

Increased knowledge of the anatomy, physiology and biomechanics of the cervical spine and the enclosed neural and vascular elements is leading to a better understanding of the importance of cervical spine stenosis, as certain clinical syndromes may ensue and may respond well to operative decompression. The present study was designed to investigate the incidence of cervical spine stenosis in patients who have required surgical treatment for cervical spondylosis, and to evaluate the clinical results.

Adult↗
PubMed1977

Collagen in the normal and hypertrophied human ventricle.

Estimates of the collagen concentration in human ventricles have been made from measurements of the hydroxyproline concentration. In the normal heart the concentration of collagen was higher in the right ventricle than in the left ventricle. Age had no effect on the ventricular concentration of collagen. Hypertrophy in the absence of a valvar lesion was not associated with an increased concentration of collagen but, owing to the increased size of the ventricle, there was an increase in the estimated total mass of ventricular collagen. The concentration of collagen in the left ventricle of patients with aortic stenosis was higher than normal. Ventricular hypertrophy seems to be accompanied by an increase in the total mass of collagen whatever the cause. Whether the concentration changes or not depends on the proportion in which the mass of collagen increases relative to the mass of muscle cells.

Adolescent↗
PubMed1977

Myocardial enzyme activities in guinea pigs during development.

The activities of hexokinase, glucose-6-phosphate dehydrogenase, and glycolytic enzymes were higher in the fetal myocardium of the guinea pig than at birth and fell progressively during the 1st mo of life. The alphaHBDH/LDH ratio of H to M subunits of lactate dehydrogenase, was low in the fetus and continued to rise during the 1st mo after birth. The distinction between the left and right ventricular activities of lactate dehydrogenase, which is clear in adult guinea pigs, was absent in the fetus and appeared during postnatal development. Glycogen phosphorylase activity was low in the fetus and at birth. The activities of beta-hydroxyacylcoenzyme A dehydrogenase, succinate dehydrogenase, malate dehydrogenase, and aspartate aminotransferase were low in the fetus, but had reached, or even temporarily exceeded, normal adult levels at birth. Palmitylcarnitine transferase activity was also low in the fetal heart compared with the newborn but continued to increase substantially during the first 2 wk after birth.

Animals↗
PubMed1977

Effects of propranolol on rat myocardial l-ornithine decarboxylase activity during exercise and hypoxia.

Ornithine decarboxylase activity was higher in the left ventricle than in the right ventricle of the rat. Swimming exercise for 2 hours caused an increase in left ventricular but not right ventricular enzyme activity. This effect was not influenced by the prior injection of propranolol, which also had no influence on the resting level of ornithine decarboxylase activity. After 4 hours' exposure to 400 mm Hg the decarboxylase activity became greater in the right ventricle. This was attributed to the increased work-load on the right ventricle caused by hypoxic pulmonary hypertension. In the left ventricle, ornithine decarboxylase showed an initial increase in activity followed by a transient decrease at 16 hours. Propranolol had no effect on the changes observed in either ventricle. It is concluded that beta-receptor stimulation is not involved in the mechanism of an increased myocardial ornithine decarboxylase activity during increased cardiac work.

Animals↗
PubMed1976

Regional chemotherapy with combined drugs in cancer of the head and neck.

Fifteen patients were treated with intra-arterial fluorouracil, methotrexate, and bleomycin in combination for palliation of advanced cancer of the head and neck. In all cases irradiation or irradiation plus surgical resection had previously failed to control the tumor. Tumor regression occured in 87% of the cases (13/15), and was complete in three (20%). Regressions lasted for up to 13 months. In four instances tumor regression permitted radical resection. The response rate achieved with this drug combination was greater than that observed earlier using each drug individually. Intra-arterial chemotherapy provides useful palliation for advanced head and neck cancer and the results can be improved with drug combinations.

Aged↗