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Biomedical subjects

P Harris

Publications and source records attributed to P Harris.

At least 289 records · Page 16Linked to original sources
PubMed1982

Anti-Dp is anti-K14.

Explore the source record for details and available documents.

Antibody Specificity↗
PubMed1982

Examination of genitalia in children: 'the remaining taboo'.

Trained student observers rated 123 physical examinations by pediatric house staff during health care maintenance visits to assess the frequency of examinations done on male and female genitalia compared with examination of ears, heart, and abdomen. Sixty-five observations were made of 21 male house staff and 58 observations of 18 female house staff. One to five examinations per physician were observed. Whereas physicians examined the ears, heart, and abdomen of pediatric patients greater than or equal to 97% of the time regardless of the sex or age of the child, female genitalia were examined 39% of the time and male genitalia 84% of the time. Female genitalia were examined approximately half as frequently as male genitalia at all ages with a trend to less frequent genital examinations on older children. Both male and female physicians examined female genitalia less frequently than male genitalia. It is concluded that increased emphasis is needed in house staff training programs on the examination of genitalia.

Child↗
PubMed1981

Pulmonary mast cells in cattle and ilamas at high altitude.

The density of mast cells in various anatomical locations within the lung were measured in a peruvian Andean llama, a Peruvian Andean cow and a sea-level-cow. These densities were determined separately around pulmonary arteries, pulmonary veins, pulmonary arterioles and venules, in the alveolar septa, and around bronchi. The total mast cell density did not differ significantly between the three animals and there were more periarteriolar and perivenular mast cells in the llama than in either of the two cows. These data do not support the hypothesis that the perivascular mast cell is responsible for initiating the vasopressor response to hypoxia. In fact it can be argued that they actually inhibit this response since a high mast cell density was found in the llama, and animal which does not develop pulmonary hypertension at high altitude.

Altitude↗
PubMed1981

Prognostic importance of anginal symptoms in angiographically defined coronary artery disease.

To evaluate the prognostic importance of anginal symptoms, 44 patients with angiographically defined coronary artery disease and no anginal symptoms at time of cardiac catheterization were selected from the Duke Harvard Collaborative Data Bank. They were "matched" with 127 symptomatic patients in the Data Bank who had similar coronary anatomy and ventricular function. Follow-up data indicated that the patients without anginal symptoms had a significantly better prognosis over a 7 year period than did those with symptoms: Annual mortality in the asymptomatic group was 2.7 percent compared with 5.4 percent in the group with angina (P 0.05). Although the patient population was a highly selective one and the matching categories were relatively broad, these results suggest that the presence of anginal symptoms may be an important independent correlate of prognosis in patients with coronary artery disease. The absence of angina did not preclude the presence of multivessel disease and did not necessarily imply a benign prognosis, because the yearly mortality rate was nearly 5 percent in the subgroup of asymptomatic patients with three vessel disease.

Angina Pectoris↗
PubMed1981

Dental study in patients with rheumatoid arthritis.

Twenty-one patients with rheumatoid arthritis took part in a comparison of three toothbrushes, each used for one month in a randomized trial. The three toothbrushes were a conventional toothbrush with modified handle to allow ease of gripping, an electric toothbrush, and thirdly a finger-stall attached to a normal toothbrush. There was no change in the patients' rheumatoid status during the trial. The patients were scored for plaque and gingival changes but no difference was found between the three toothbrushes. We recommend a standard toothbrush with a modified grip for the rheumatoid hand; the extra expense of an electric toothbrush cannot be justified.

Arthritis, Rheumatoid↗
PubMed1981

Small pulmonary arteries in some natives of La Paz, Bolivia.

A histological study was made of the small pulmonary blood vessels in pieces of lung obtained at necropsy from 19 long-term residents of La Paz, Bolivia (3800 m). There was variation in the response of the pulmonary vasculature of these subjects to the chronic hypoxia of high altitude. The most characteristic finding, seen in seven of the 16 cases beyond infancy, was distal extension of vascular smooth muscle into pulmonary arterioles as small as 20 micrometer in diameter. Medial hypertrophy of the muscular pulmonary arteries occurred in only three of these seven subjects. Intimal fibrosis was seen in eight of the 19 cases and was ascribed to age; such fibrotic proliferation may affect the reversibility of hypoxic pulmonary hypertension and associated vascular changes in highlanders.

Adult↗
PubMed1980

The prognosis of patients sustaining severe cervical spine injury (C2-C7 inclusive).

In a study of 145 patients with severe cervical spine injury, it was found that 79 had serious neurological disturbance. A policy of the earliest possible referral to a spinal paralysis service is recommended. Associated injuries and in particular a head injury can make early precise neurological diagnosis difficult, and may affect management of the spinal injury. The use of Gardner Wells Skull Tongs and the Edinburgh Simpson Bed is recommended. Early spinal operation does not influence outcome of neurological function. Anatomical re-alignment of the spine is not essential for neurological recovery. Myelography is very rarely of benefit in assisting diagnosis and treatment. Glucocorticosteroids and Mannitol do not appear to influence neurological recovery. The prognosis in relation to clinical neurological syndromes is discussed.

Adolescent↗
PubMed1980

Distribution of tubulin-containing structures in the egg of the sea urchin Strongylocentrotus purpuratus from fertilization through first cleavage.

Eggs of the sea urchin Strongylocentrotus purpuratus were examined by indirect immunofluorescence microscopy for tubulin-containing structures at intervals from fertilization through first cleavage. The staining revealed that the monaster is made up not only of the sperm aster but also of tubulin-staining fibers originating elsewhere in the egg. The monaster does not divide directly but is broken down first before the amphiaster or interphase asters begin to form. The interphase asters reach a peak of development at the streak stage and are in turn broken down before the formation of the mitotic apparatus. The breakdown of the monaster, interphase asters, as well as the asters of the mitotic apparatus proceeds from the cell center or aster centers to the periphery of the cell and is followed by growth of new asters, also proceeding outward from the aster centers. The pattern suggests a transient wavelike movement of some condition, or factor, which favors microtubule depolymerization.

Animals↗
PubMed1980

Echocardiographic documentation of vegetative lesions in infective endocarditis: clinical implications.

Eighty-seven patients with the clinical syndrome of infective endocarditis were examined by M-mode and two-dimensional echocardiography. Patients were divided into two groups based on the presence or absence of echocardiographically detected vegetative lesions. Group 1 consisted of 47 patients with one or more vegetations. Group 2 consisted of 40 patients without evidence of vegetations. Group 1 patients had a higher rate of complications: emboli, congestive heart failure and the need for surgical intervention. Analysis of morphologic characteristics of the vegetations in group 1 was of no predictive value for complications in individual patients. Two-thirds of the vegetations persisted unaltered well beyond the period of bacteriologic cure without significant complications. No characteristic alteration of the vegetations predicted the efficacy of medical therapy. Although the detection of vegetations by echocardiography in patients with the clinical syndrome of endocarditis clearly identifies a subgroup at risk for complications, decisions regarding clinical management made solely on the basis of the presence or absence of vegetative lesions are hazardous. Management of such patients must continue to be based on the clinical integration of multiple factors.

Adolescent↗
PubMed1980

Cyclic AMP-dependent protein kinases in the rat myocardial cytosol.

The optimal assay conditions for rat myocardial cytosol protein kinases have been determined. The assay medium contained in 0.25 ml: 40 mM Tris/HCl pH 7.4, 5 mM MgCl2, 600 micrograms histone f1, 10--30 micrograms enzyme protein, 32 microM [gamma-32P]-ATP, with or without additions of 1 microM cAMP. The incubation time at 37 degrees C was 5 minutes. The protein kinase activity in the absence of cAMP decreased with development, while the activity in the presence of cAMP remained unchanged. The protein kinase activity of the left ventricle was higher than that in the right ventricle.

Aging↗