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Biomedical subjects

P Hansson

Publications and source records attributed to P Hansson.

At least 73 records · Page 4Linked to original sources
PubMed1989

Pain development and consumption of analgesics after oral surgery in relation to personality characteristics.

In the present study a survey has been performed of the pain development and analgesic intake in 100 patients following elective oral surgery of impacted third molars in relation to preoperative assessment of personality characteristics. Our results show that no sex differences existed preoperatively concerning personality characteristics, concerning postoperative pain development or analgesic consumption. Fourteen patients reported no pain at all and 40 patients did not use any analgesics in the postoperative period. We also found a good correlation between total sum of pain scores and analgesic intake. Patients undergoing surgery in the morning reported a lower total sum of pain scores, reported pain at fewer occasions and tended to require less analgesics than patients being subjected to surgery in the afternoon. The patients who reported a total sum of pain scores in the upper percentile during the postoperative period rated their general health worse, as rated on the General Health (GH) questionnaire, and used more analgesics than did patients in the lower percentile. Also, patients not using any analgesics reported less symptoms of distress according to the GH scale as compared to patients using analgesics. In general, however, less than 10% of the variance in postoperative pain and consumption of analgesics could be explained by the preoperative factors studied.

Adolescent↗
PubMed1989

Cell-density-dependent release of hepatic lipase from cultured rat hepatocytes.

Cultured rat hepatocytes release the enzyme hepatic lipase. In this study we investigated the effect of cell density on this metabolic function under a variety of experimental conditions. The release of hepatic lipase from cultured rat hepatocytes exhibits a cell-density dependence, the secretion per mg cell protein being increased with increasing cell density. When cell density dependence was taken into consideration no significant effect of insulin on the release of hepatic lipase from cultured hepatocytes was observed, whereas glucagon suppressed the release. Glucose stimulating the release of the enzyme, especially in cultures with high cell density.

Animals↗
PubMed1988

Carbonic anhydrase enzyme histochemistry of cranial nerve primary sensory afferent neurons in the rat.

Hanssons' enzyme histochemical method for the demonstration of carbonic anhydrase has been used to examine primary sensory neurons of cranial nerves in the rat (cochlear ganglion cells excluded). Numerous carbonic anhydrase positive neurons were present in the trigeminal and geniculate ganglia as well as in the mesencephalic trigeminal nucleus. A few carbonic anhydrase positive ganglion cells were found in the nodose ganglion, but none in the petrosal and vestibular ganglia. However, in the latter ganglia, satellite cells surrounding the neurons frequently showed staining for carbonic anhydrase.

Animals↗
PubMed1988

Pain intensity measurements in patients with acute pain receiving afferent stimulation.

Six different pain rating scales, including a "pain relief scale", were compared in 80 patients suffering acute orofacial pain. Pain intensity measurements were made before and after a 30 min period of afferent stimulation (TENS/vibration and placebo). A good correlation was found between pain scores derived from the pain relief scale, visual analogue-, numerical- and graphic rating scales. The verbal rating scale did not perform well. The pain relief scale and the numerical rating scale are interesting alternatives to the established visual analogue scale.

Adolescent↗
PubMed1988

Does acute intraoral pain alter cutaneous sensibility?

Cutaneous sensibility was tested in eight patients suffering from acute postoperative intraoral pain. Tactile-, cold-, warm-, and heat-pain thresholds as well as reaction time to cold pulses were unaffected by the presence of pain. However, reaction time to warm pulses was increased in the painful area on the day of pain compared to a non-painful state. The findings are discussed in relation to (1) functional convergence of different sensory fibres on central neurons (2) the phenomenon of diffuse noxious inhibitory controls and (3) secondary hyperalgesia. The observed effect of clinical pain on the warm pathway could be explained as an intrasegmental noxious inhibitory effect.

Adolescent↗
PubMed1987

Effects of lactation and removal of pups on the rate of triacyglycerol/fatty acid substrate cycling in white adipose tissue of the rat.

The rate of the triacylglycerol/fatty acid substrate cycle was measured in vivo in adipose tissue of virgin and lactating rats with pups removed. The rate decreased by 70% in adipose tissue of lactating rats and increased 9-fold on removal of the pups. Similar differences in cycling rate were seen in adipose tissue incubated in vitro in the presence of isoprenaline.

Adipose Tissue↗
PubMed1987

Is acupuncture sufficient as the sole analgesic in oral surgery?

Twenty-six patients who were undergoing operative removal of an impacted third molar were given acupuncture as an alternative to conventional local analgesia. Pain ratings during different stages of the surgical procedure showed that gingival and periosteal incisions were tolerated, with only minor pain experienced by 18 of the patients. During mucoperiosteal flap dissection 12 patients experienced unacceptable pain. In total, only 2 of the patients tolerated the entire procedure; however, they reported severe pain during the final part of the operation. In conclusion, it seems that acupuncture as performed in the present study could not subserve as a routine method for analgesia in this type of operative procedure.

Acupuncture Therapy↗
PubMed1987

Thermal sensitivity is not changed by acute pain or afferent stimulation.

The effect of conditioning stimulation on thermal sensitivity and clinical pain was studied in 40 patients and six healthy subjects. Thresholds regarding cold, warm and heat pain perception did not differ significantly between the painful and non-painful skin areas in patients or between patients and healthy subjects before stimulation. The patients received either 100 Hz TENS, 2 Hz TENS, 100 Hz vibration, or placebo. No significant changes in thermal sensitivity were observed during and after conditioning stimulation in any of the test groups, although 24/40 (60%) of the patients reported reduction of their clinical pain intensity. The results indicate that (a) thermal sensitivity is not influenced by the presence of clinical pain, (b) the effects of stimulation on thermal sensitivity (thresholds) and clinical pain are not closely related, (c) central inhibitory effects of TENS and vibration are crucial for their pain relieving capacity.

Adult↗
PubMed1986

Influence of naloxone on relief of acute oro-facial pain by transcutaneous electrical nerve stimulation (TENS) or vibration.

Twenty-eight patients suffering acute pain following operative removal of impacted third molars took part in the present study. In 20 patients who reported pain reduction exceeding 25% of the initial pain intensity during vibratory stimulation (100 Hz) or TENS (2 or 100 Hz), only 1 patient (given 2 Hz TENS) reported pain increase after injection of 0.8 mg naloxone (i.v.). In 8 patients, not treated with afferent stimulation, 2 experienced increase in pain intensity after naloxone injection. The results show that pain relief using TENS or vibration is not influenced by naloxone.

Acute Disease↗
PubMed1986

Thyroid hormones stimulate the release of hepatic lipase from cultured rat hepatocytes.

We have investigated the effects of triiodothyronine (T3) and thyroxine (T4) on the heparin-stimulated release of hepatic lipase (HL) activity from cultured rat hepatocytes. Addition of T4 (1-10 nmol/l) to the culture medium for 24 h stimulated HL release from cells derived from normal and hypothyroid rats, whereas T3 (0.1-10 nmol/l) was active (at the highest concentration) only in hepatocytes from hypothyroid animals. The effects of T4 could largely be abolished by 5-iodo-2-thiouracil (0.1 mmol/l), an inhibitor of T4-5'-deiodinase. This indicates that the effects of T4 treatment are exerted by T3, formed by deiodination in the hepatocytes.

Animals↗
PubMed1986

Influence of stimulus frequency and probe size on vibration-induced alleviation of acute orofacial pain.

The pain-relieving effect of vibratory stimulation, using different stimulus parameters, and placebo stimulation in acute orofacial pain is reported. The influence of 10-, 100-, and 200-Hz vibrations on pain reduction was studied in 96 patients; two different probe sizes were used. 54 out of 76 patients, receiving vibrations at any of the above frequencies, reported relief of pain to some extent, while only 6 out of 20 patients receiving placebo treatment experienced pain alleviation. No significant differences were found between the different frequencies and probe sizes used regarding the pain-relieving effect. However, placebo stimulation was significantly less effective than any kind of vibratory stimulation. Induction time for pain relief was significantly shorter using the larger probe as compared to using the smaller probe, regardless of frequency. The results indicate that the vibratory frequency (10-200 Hz) for activation of pain-inhibitory mechanisms is not critical in acute orofacial pain. Also, spatial summation from vibration-sensitive afferents seems to be of importance for a fast activation of the inhibitory systems.

Adolescent↗
PubMed1986

Comparison of tympanometry and otomicroscopy during healing of otitis media.

One hundred ears in 50 children with acute otitis media during healing were examined with tympanometry and the objective measures were compared with the subjective evaluation of otomicroscopy by four otolaryngologists independently. Tympanometric findings could more often correctly suggest reduced tympanic membrane mobility than did otomicroscopy, but both methods gave an equally good indication of middle ear effusion. However, otomicroscopy was necessary when evaluating the colour and the appearance of the tympanic membrane and revealed middle ear effusion in a few cases with 'normal' tympanometry. As a rule: normal tympanometry (Jerger type A) was closely correlated with a normal tympanic membrane and a normal middle ear without effusion; pathological tympanometry (Jerger type B) was accompanied by middle ear effusion and needed follow-up; ears with tympanometric pressure more negative than -150 mmH2O but more positive than a flat curve needed otomicroscopy to identify middle ear effusion.

Acoustic Impedance Tests↗
PubMed1985

Hepatic lipase activity increases after liver denervation in the rat.

We have investigated the effects of hilar denervation of rat liver upon the activity of hepatic lipase determined in tissue extracts. Denervated animals had an enzyme activity of 7.89 +/- 0.37 mU/mg protein, compared to 6.45 +/- 0.43 in sham-operated controls (mean +/- S.E.; P less than 0.05). We conclude that hepatic innervation may contribute to the regulation of hepatic lipase activity.

Animals↗
PubMed1985

External fixation of ipsilateral fractures of the femur and tibia.

In five patients with ipsilateral femoral and tibial shaft fractures the Hoffmann apparatus was used to stabilize the fractures of both the femur and tibia. The patients walked early and there were no disturbances of fracture healing. The pin track became infected in three patients. It is suggested that in patients with ipsilateral fractures of the femur and tibia external fixation is indicated for the tibia and that the fracture of the femur should be stabilized by closed medullary nailing. If the patient is critically ill or if there is gross comminution of the femur external fixation is indicated for this fracture as well.

Adolescent↗
PubMed1985

The influence of extrasegmental mechanical vibratory stimulation and transcutaneous electrical nerve stimulation on histamine-induced itch.

The effect of peripheral conditioning stimulation on experimentally induced pruritus was studied in 12 healthy volunteers. Itch was induced by intradermal injections of histamine on the upper arms. Vibration at 100 Hz and transcutaneous electrical nerve stimulation (TENS) at 2 and 100 Hz were applied extrasegmentally (dorsal aspect of the lower part of the leg, ipsilateral to the injected arm) for a period of 5 min following induction of itch. The effect of a 5 and 30 min stimulation period before itch elicitation was also studied as well as the influence of placebo stimulation. No significant effects were obtained with 100 Hz vibration and 100 Hz TENS, and none with placebo stimulation, whereas significant itch reduction was seen using 2 Hz TENS. The local skin flare response following histamine injections was not altered following conditioning stimulation of any type.

Adult↗
PubMed1985

The correlation between otoscopy and otomicroscopy in acute otitis media during healing.

One hundred ears in 50 children were investigated independently by four otolaryngologists during healing of acute otitis media. Interobserver variations of the tympanic membrane were studied. Clinical findings with otoscopy were correlated with otomicroscopy. The investigation showed that there is a substantial interindividual variation in evaluation of the tympanic membrane. Otomicroscopy improves the diagnostic performance and reduces interobserver variations. Interobserver agreement was best for normal tympanic membranes.

Adolescent↗