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Biomedical subjects

P Hansen

Publications and source records attributed to P Hansen.

At least 109 records · Page 6Linked to original sources
PubMed1981

Hyperprolactinemic amenorrhea induced by metoclopamide (PrimperanR).

Secondary amenorrhea, elicited by metoclopamide (PrimperanR) induced hyperprolactinemia, was found in a 24-year-old woman. Withdrawal of the drug was followed by normalization of the hyperprolactinemia, as well as the menses. For many years metoclopamide (PrimperanR) has been used for various dyspeptic inconveniences, such as gastro-esophageal reflux, ventricular rentention and postoperative tarm-atom. Well-known secondary effects are reported to be drowsiness, uneasiness, restlessness and extra-pyramidal secondary effects in the form of acute dystom. The present case of secondary amenorrhea caused by metoclopamide (PrimperanR) induced hyperprolactinemia has been verified clinically, serologically and by treatment.

Adult↗
PubMed1981

Glucocorticosteroid enhancement of immunoglobulin synthesis by pokeweed mitogen-stimulated human lymphocytes.

We studied the role of the T lymphocyte in GCS enhancement of PWM-stimulated IgG synthesis by human peripheral blood mononuclear cells. Purified T or B lymphocyte subpopulations were pretreated with 10(-6) M prednisolone or recombined at various T:B ratios and 10(-6) M prednisolone was added. PWM-stimulated IgG synthesis was measured in the culture supernatants at 8 days by radioimmunoassay. Addition of prednisolone to cultures of autologous and allogeneic reconstituted mixtures of T and B lymphocytes resulted in enhancement of PWM-stimulated IgG synthesis. This effect was observed with constant and increasing numbers of lymphocytes in culture, independent of T:B ratio and occurred with purified B lymphocytes containing monocytes. Pretreatment of purified B lymphocytes containing monocytes but not purified T lymphocytes with prednisolone enhanced PWM-stimulated IgG synthesis in reconstituted mixtures of T and B lymphocytes. We propose that GCS enhancement of PWM-stimulated IgG synthesis by human mononuclear cells is independent of T lymphocyte regulation.

B-Lymphocytes↗
PubMed1981

Glucocorticosteroid enhancement of immunoglobulin synthesis by pokeweed mitogen-stimulated human lymphocytes. III. Common variable immunodeficiency.

We studied the effect of glucocorticosteroids (GCS) on IgG synthesis by peripheral blood mononuclear cells from 19 patients with common variable immunodeficiency (CVID). Purified T and B lymphocyte subpopulations from patients and normal subjects were recombined at various T : B ratios and cultured for 8 days unstimulated, stimulated with pokeweed mitogen (PWM) and in the presence of prednisolone. IgG synthesis was measured in the culture supernatants by radioimmunoassay. Enhancement of PWM-stimulated IgG synthesis by prednisolone at high T : B ratios was found in nine patients, four of whom produced negligible amounts of IgG with PWM alone. In four patients, enhancement by prednisolone of IgG synthesis by purified B lymphocytes was noted. In three out of eight patients whose IgG synthesis was increased by normal allogeneic T lymphocytes with PWM and prednisolone, negligible amounts of IgG were produced by similarly treated autologous combinations. T lymphocytes from CVID patients provided less help compared with normal T lymphocytes for IgG synthesis by normal B lymphocytes at high T : B ratios even in the presence of prednisolone. GCS in vitro enhance IgG synthesis by lymphocytes from some but not all patients with CVID by a mechanism which appears independent of GCS action on regulatory T lymphocytes.

Adolescent↗
PubMed1980

Hemoglobin A1c as an indicator of long term blood glucose levels in diabetics with special reference to diabetic pregnancy.

Hemoglobin A1c in diabetics has been shown to be an index of average blood glucose levels in the preceding 1-2 months. We confirm this relationship in a group of 12 insulin-treated diabetics and extend it to 16 pregnant insulin-treated patients as well. Lower levels of HbA1c in pregnancy could be explained by better control. In an ongoing sequential study of 5 pregnant diabetics home-monitoring their blood glucose, we have an impression, that this relationship holds true for individual patients. If this is confirmed, the level of glycosylated hemoglobins in pregnancy may be used as a warning signal for deterioration of glucose control in out-patients.

Blood Glucose↗
PubMed1979

Comparison of lipid status in the hearts of piglets and rats on short term feeding of marine oils and rapeseed oils.

A series of 4 experiments with piglets and one experiment with rats has been conducted to establish the cardiac lipid status of weanling (3 weeks old) male animals fed fats with different contents of docosenoic fatty acids. Experimental fats were rapeseed oil (RSO) (48.0% 22:1), refined fish oil (RFO) (14.6% 22:1), partially hydrogenated fish oil (PHFO) (14.3% 22:1) and lard (0% 22:1) combined with sunflower seed oil (SFO) in different proportions in diets with 21% total fat. Lipidosis could not be detected in piglets as increased heart weights, by chemical assay for myocardial contents of triglycerides, or by accumulation of docosenoic fatty acids or nonesterified fatty acids (NEFA). In rats, diets with RSO at a level of 16% increased myocardial triglyceride and docosenoic fatty acid contents about 7 times while the effect on cardiac NEFA was inconsistent. Histological examinations of the hearts revealed stainable intracellular fat droplets in some piglets fed 16% RSO for 8 to 13 days, but not after 2, 4 and 6 and 16, 19 and 22 days of feeding. After 10 days of feeding, mild to moderate histological lipidosis was found in piglets fed diets containing 2% or more of 22:1 fatty acids, with no significant difference between RSO, RFO and PHFO in this respect. The same diets in rats gave about 5 times more histological lipidosis than in piglets. This is attributed to a difference in species response, the rat reacting in a more pronounced manner than the piglet. The cardiac lipidosis no-effect level in piglets corresponded to a daily intake of docosenoic fatty acids of 0.4 g per kg body weight. Mild lipidosis was also found in a few animals on docosenoic acid-free diets.

Animal Feed↗
PubMed1979

Hyperactivity: pediatricians' and teachers' perspectives.

Research of related literature indicated that disagreement existed among professionals as to the causes, diagnoses, treatments and descriptors of hyperactivity. A questionnaire was developed to compare the responses of a group of pediatricians, and a group of master's degree candidates in special education (79.18%) of whom were teachers with an average of 4.72 years of teaching experience) on four variables relating to hyperactivity diagnoses, etiology, treatments, and labels. Significant differences between the two groups were noted in their responses to the dependent measures.

Attitude↗
PubMed1977

Bilirubin displacing effect of stabilizers added to injectable preparations of human serum albumin.

Stabilizers added to preparations of human serum albumin before heat treatment were tested for bilirubin displacing effect, using the peroxidase method. It was found that N-acetyltryptophan and sodium caprylate displace bilirubin from its complex with human serum albumin in vitro. The quantitative findings were used for a rough estimate of the effect of these substances on the free bilirubin concentration in blood plasma, expected when stabilized albumin preparations are given intravenously for prevention of kernicterus. The calculated effect is a delay of the decrease of free bilirubin concentration, or even a temporary increase. Sodium mandelate displaces less strongly.

Bilirubin↗
PubMed1977

Post-operative flow-volume loops.

A study of flow-volume curves pre- and post-operatively demonstrated a marked difference between bronchitic and non-bronchitic patients. All bronchitic patients showed lower flow rates at low lung volumes post-operatively, when compared with their pre-operative values. Non-bronchitic patients all had higher flow rates for the same comparison.

Abdomen↗
PubMed1977

Post operative pulmonary compliance.

Lung compliance was studied pre-operatively and post-operatively in a group of patients having abdominal surgery. Lung compliance was shown to be markedly reduced post-operatively especially in the patients with chronic bronchitis.

Abdomen↗
PubMed1977

Postoperative arterial hypoxaemia.

Postoperative arterial oxygen tension was measured in a group of patients. Unacceptably low levels were found in 32% of the patients and this hypoxaemia persisted in some cases for three days. The results enforce the principle that some patients whould be given prolonged oxygen therapy and this should cease only when blood gas analysis demonstrate the patients ability to maintain a safe PaO2 breathing air.

Humans↗
PubMed1976

Monitoring immune function during immunosuppressive therapy.

Twenty-nine patients with a variety of connective tissue disorders were studied for the effects of immunosuppressive therapy on non-specific parameters of immune function. Baseline studies prior to therapy showed a frequent incidence of anergy (13%) lymphopenia (31%) and abnormal PHA response (43%). Despite these abnormalities in untreated patients it was possible to show an even higher incidence of anergy (31%), lymphopenia (66%) and abnormal PHA response (77%) following immunosuppressive treatment. The changes in lymphocyte count and PHA response were found to be statistically significant. It was found, paradoxically, that delayed hypersensitivity responses improved following institution of therapy in three patients. Clinical efficacy of immunosuppression correlated with lymphopenia and depressed PHA responses; in particular in the five patients with uncontrolled disease, these parameters were normal. Lymphocyte counts and PHA responses are the most simple and informative procedures to monitor immunosuppression in patients.

Collagen Diseases↗
PubMed1976

Defective immune and phagocytic functions in uraemia and renal transplantation.

The humoral, cellular and neutrophil responses of uraemic patients maintained by haemodialysis were compared with those of renal transplant recipients. Humoral immunity was reduced only in the transplant group. Cell-mediated immunity was abnormal in both groups but more decreased in the transplant group studied particularly within 3 months of transplantation. The neutrophil bactericidal capacities were defective cellular immunity, but fatal infections occurred only in transplant patterns over 40 years of age with combined cellular and neutrophil defects. No single test was predictive of graft survival in uraemic patients. The depressed cellular immune responses in uraemia, of the degree seen in the immunosuppressed transplant recipient, may explain the better prognosis of renal transplants compared with other organ transplants.

Antibody Formation↗
PubMed1976

Pulmonary water content in critical illness.

Pulmonary extravascular water content was measured using a double indicator technique and results compared with chest radiography. It is concluded that careful chest radiography is an effective and simple technique for assessing the pulmonary extravascular water content.

Body Water↗
PubMed1976

Post-operative respiratory function: a ventilation-perfusion study.

Many studies have shown that after uncomplicated abdominal surgery arterial hypoxaemia frequently occurs because of regional underventilation in relation to perfusion. This paper produced evidence that shows a small increase in physiological dead space to tidal volume ratio following general anaesthesia for abdominal surgery. This increase is thought to be due to tachypnoea rather than alteration in pulmonary blood flow.

Abdomen↗