Biomedical subjects

P Hänggi

Publications and source records attributed to P Hänggi.

At least 19 recordsLinked to original sources

PubMed2001

Nonlinear electron current through a short molecular wire.

The voltage and the temperature behavior of inelastic interelectrode current mediated by a short molecular wire is analyzed within a nonlinear kinetic approach that accounts for strong Coulomb repulsion between transferring electrons. When the coupling to the heat bath occurs via high-frequency vibration modes we predict a generally nonlinear current-voltage characteristics (an Ohmic behavior at small voltage, rising towards saturation and being followed by an abrupt decrease at large voltage) and a bell-shaped current response vs temperature at not too large temperatures.

Journal Article↗

PubMed2000

Stochastic resonance in ion channels characterized by information theory.

We identify a unifying measure for stochastic resonance (SR) in voltage dependent ion channels which comprises periodic (conventional), aperiodic, and nonstationary SR. Within a simplest setting, the gating dynamics is governed by two-state conductance fluctuations, which switch at random time points between two values. The corresponding continuous time point process is analyzed by virtue of information theory. In pursuing this goal we evaluate for our dynamics the tau information, the mutual information, and the rate of information gain. As a main result we find an analytical formula for the rate of information gain that solely involves the probability of the two channel states and their noise averaged rates. For small voltage signals it simplifies to a handy expression. Our findings are applied to study SR in a potassium channel. We find that SR occurs only when the closed state is predominantly dwelled upon. Upon increasing the probability for the open channel state the application of an extra dose of noise monotonically deteriorates the rate of information gain, i.e., no SR behavior occurs.

Biophysical Phenomena↗

PubMed1996