Biomedical subjects

P H Kingisepp

Publications and source records attributed to P H Kingisepp.

7 recordsLinked to original sources

PubMed2001

Changes of heart rate and blood pressure in registration of forced respiration flow-volume loop.

Changes in heart rate (HR) and finger mean blood pressure (MBP) during registration of the flow-volume loop of forced respiration in healthy young subjects were studied. Breathing patterns of performing the flow-volume loop of forced respiration (forced respiratory manoeuvre, FRM) as well as the related responses of cardiovascular parameters in different subjects were found to vary to a large extent. FRM has a remarkable influence on the cardiovascular system: during FRM the peak values of MBP were 19 +/- 9 mmHg higher than baseline values and the peak values of HR were 30 +/- 11 beats min-1 higher. We conclude that it is essential to pay attention to a remarkable elevation of blood pressure in functional breathing tests in patients with high blood pressure.

Adolescent↗

PubMed2001

Spirometric reference values in Estonian schoolchildren.

This study was conducted to describe the relationship between anthropometric parameters and lung function in Estonian children, to determine the reference values for spirometry, and to compare these results with other data sets. The results are based on 1170 healthy non-smoking children (643 girls and 527 boys), aged 6-18 years. The spiroanalyser Pneumoscreen II (Jaeger) was used to register dynamic lung parameters. Natural logarithmic values of lung volumes, standing or sitting height and age were used in the final regression model. Prediction equations for forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), peak expiratory flow, forced expiratory flows when 50 and 75% of FVC has been exhaled, and mean forced expiratory flow over the middle 50% of the FVC for both sexes are presented. In comparison with recent data from European children the reference values were close for FVC, the differences were bigger for FEV1 and forced expiratory flows, especially in taller children.

Adolescent↗

PubMed1998

Hot-wire anemometer for spirography.

The use of a constant temperature hot-wire anemometer flow sensor for spirography is reported. The construction, operating principles and calibration procedure of the apparatus are described, and temperature compensation method is discussed. Frequency response is studied. It is shown that this hot-wire flow transducer satisfies common demands with respect to accuracy, response time and temperature variations.

Humans↗

PubMed1997

The effect of cholecystokinin tetrapeptide on respiratory resistance in healthy volunteers.

The effects of cholecystokinin tetrapeptide (CCK-4) on respiratory resistance were studied in 14 healthy volunteers by the registration of slow vital capacity and flow volume loop during forced respiration test. The administration of CCK-4 (50 micrograms) was performed in a double-blind and placebo-controlled design. Injections of CCK-4 induced prominent and time-limited paniclike symptoms in all healthy volunteers. Four volunteers (29%) experienced a panic attack. Subjective dyspnea was experienced by the majority of subjects at the peak of CCK-4 effect and seemed related to a diminution in vital capacity parameters; however, the forced respiration test did not reveal bronchoconstriction after CCK-4 challenge. Administration of CCK-4 also induced a short-lasting increase in heart rate and skin blood flow. This study suggests that dyspnea induced by CCK-4 is not related to changes in respiratory resistance.

Adult↗

PubMed1997

Emotional and cognitive factors connected with response to cholecystokinin tetrapeptide in healthy volunteers.

This article examines the effect of baseline anxiety, anxiety sensitivity and dysfunctional attitudes on the response to cholecystokinin tetrapeptide (CCK-4) in healthy volunteers. CCK-4 and placebo were administered to 14 subjects in a double-blind manner. Four volunteers experienced a panic attack after CCK-4 administration. Those subjects who panicked had significantly higher baseline scores on dysfunctional attitudes. Dysfunctional thought patterns appeared also to predict number of symptoms and experience of cognitive and affective symptoms during injection. Baseline anxiety as well as anxiety sensitivity predicted reactions to placebo but not panic responses to CCK-4. Results suggest that a general tendency towards erroneous interpretation of information has some role in mediating the panicogenic effects of CCK-4, and also interpersonal sensitivity may constitute a vulnerability factor for panic. Psychological factors that have been considered more specific to panic disorder, namely high state and trait anxiety as well as anxiety sensitivity, appeared mainly to determine general reactions to a threatening situation.

Adult↗

PubMed1997

Differences in lung function and chest dimensions in school-age girls and boys.

The present analysis was undertaken to find out whether differences in the performance of the lungs of boys and girls of the same height are explicable by differences in thoracic size. We measured forced vital capacity (FVC), peak expiratory flow (PEF) and forced expiratory flows (FEFs), when 50% and 75% of FVC had been exhaled (FEF50, FEF75), and standing height, chest width and depth and biacromial diameter in 1187 schoolchildren aged 6-18 years. Thoracic dimensions were usually greater in boys than in girls of the same height, except for the height range of 150.0-164.9 cm. For this height range, the pulmonary function variables (PEF, FEF50, FEF75 and PEF/FVC) were significantly higher in girls, and for FVC almost as high as the male values. For FEF50/FVC and FEF75/FVC, the female values were larger over the whole height range (115.0-184.9 cm), but even for these parameters the differences were greatest for the height range 150.0-164.9 cm. In conclusion, very similar growth patterns of lung function and thoracic parameters can suggest that differences in the lung function parameters of boys and girls of the same height may be explained by differences in the thorax size.

Child↗

PubMed1995

Lung function in Estonian children: effect of sitting height.

The present analysis formed part of the population study of Estonian school-children and was undertaken in order to examine the relationships between lung function variables, standing and sitting height. We measured forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), peak expiratory flow and forced expiratory flows when 50 and 75% of FVC had been exhaled, and anthropometric indices in 645 healthy schoolchildren, aged 6-18 years. The growth spurt in standing and sitting height occurred between the ages of 11 and 13 years in girls, and 13 and 15 years in boys. Growth spurts of lung parameters occurred during the same periods. FVC and FEV1 showed close correlations (r = 0.89-0.94) with all anthropometric parameters and age, whereas correlation coefficients for the flows were less close (r = 0.65-0.88). In boys, correlations between sitting height and lung function variables were greater than those with standing height. Using stepwise regression analysis, in boys sitting height was selected in all lung function parameters, and in girls sitting height was never selected. We conclude that there is a very close correlation between sitting height and lung function variables. The use of sitting height in parallel with standing height in predicted values for Estonian schoolchildren would make the values more exact.

Adolescent↗