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Biomedical subjects

P Gu

Publications and source records attributed to P Gu.

36 records · Page 2Linked to original sources
PubMed1993

[Chemosensitivity testing of fresh human gastrointestinal cancers using AgNOR assay].

The argyrophilic staining of nucleolar onganizer region (AgNOR), a simple colorimetric test, has been adapted for chemosensitivity testing of human gastric and colorectal cancers. Seven different chemotherapeutic agents were tested. The drug sensitivity was measured and compared according to the decrease rate of AgNOR granules between control tumor cells and tumor cells treated with antitumor drugs. Only 3 of 10 cases of advanced gastric carcinoma were sensitive to one antitumor agent. Most colorectal carcinoma cases (18/20) were sensitive to at least one antitumor agent. The sensitive sequence of antitumor agents we have had in this study was relative to clinic. The method and characteristics of AgNOR assay as a chemosensitivity test was introduced. It's value is being observed.

Antineoplastic Agents↗
PubMed1991

[DNA content measured by flow cytometry in primary hepatic carcinoma and its clinical significance].

Twenty-two samples of resected primary hepatic carcinoma (PHC) and liver tissues of resective margin were studied by flow cytometric single-variable analysis combined with clinical data. The results showed that the DNA content measured by flow cytometry was a relatively independent factor indicating biological behavior in PHC. The DNA content was increased and the great majority of PHC cells were of aneuploid cells (90.0%). DNA histograms varied and the occurrence rate of multi-aneuploid was 35%. The DNA content distributed widely, indicating that PHC cells were heterogeneous. The occurrence rate of aneuploid was 61.9% in histologically negative hepatic tissues of resective margin, and it was not correlated with categories of hepatic resection. The existence of aneuploid cells in liver tissues of resective margin is thus considered an important factor for the recurrence of PHC. We suggest that surgical treatment is inadequate and adjuvant therapy is required.

Adult↗