Biomedical subjects
Publications and source records attributed to P Groza.
In this material it was confirmed that the irradiated rats present a two-phase corticosterone hypersecretion. The responses are greater to higher doses of irradiation (700 R as compared with 500 R). The postirradiation hyperglycemia is not correlated with the corticosterone hypersecretion, having its peak value a day before.
The cardiac frequency and adrenal and urinary catecholamine content were investigated on 10-minutes centrifuged rats (+6 Gz). It was found that the heart responds in an individual manner, with a general tendency to tachycardia. Under the same conditions after 1 1/2 minute the adrenal noradrenaline response was absent, after 3' and 6' the adrenal noradrenaline content was augmented and the adrenaline one diminished, and after 10' the response vanished. Hypergravitation does not change the urinary noradrenaline elimination collected after 10 minutes of centrifugation, but that of adrenaline is augmented in one of the two explored animal groups. The difference between the two groups may be explained by the great individual variations, as results from the cardial frequency (appreciated by teleelectrocardiogram). The environmental stress produces similar but more reduced catecholamine modifications.
In experiments carried out in male Wistar rats submitted in laboratory to a 2200-m depressurization the urinary noradrenaline and adrenaline elimination, as well as the plasma corticosterone level were investigated. In rats previously submitted 12 days only to the environmental stress the true depressurization (7 days) produced a relatively increased noradrenaline and adrenaline elimination. A similar increased catecholamine output was observed in rats submitted directly to hypoxia. The plasma corticosterone level was unmodified by hypoxia of the same value.
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The effect of acceleration and hyperthermia on the antidiuretic hormone secretion (ADH) was investigated in rats both separately and simultaneously. The two conditions of stress elicited a rise in plasma ADH concentration in proportion to their intensity. Concomitant exposure to the two factors produced an additional effect. The parallel histochemical studies using methods for demonstrating RNA, proteins and the neurosecretory material in the supraoptic nucleus, showed the synthesis and depletion of the hormone content in correlation with the plasma concentration of ADH.
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