Search PubMed⌕ Search

Biomedical subjects

P Gregor

Publications and source records attributed to P Gregor.

At least 127 records · Page 7Linked to original sources
PubMed1984

Echocardiography in sarcoidosis.

We examined 39 patients with biopsy proven sarcoidosis of the lungs by one-dimensional, two-dimensional and pulsed Doppler echocardiography. In 18 (46.2%) we revealed a prolapse of one or both cusps of the mitral valve which can partly explain some of the complaints and objective findings in these patients (palpitations, chest pain, changes on ECG resembling myocardial infarctions, murmurs, etc.). A minor pericardial effusion was present in 8 (20.5%) of the patients. The finding of reduced systolic thickening and excursions of the interventricular septum in 4 (10.2%) may be related to the frequent prevalence of sarcoid granulomas in the septum. Asymmetric septal hypertrophy, recorded in 4 (10.2%) patients, may have had a similar origin. Administration of corticosteroids did not influence in a significant way any of the echocardiographic indicators nor the amount of pericardial effusion. In patients with palpitations and extrasystolic arrhythmias, however, the extrasystoles disappeared and the patients reported subjective relief in all instances.

Adrenal Cortex Hormones↗
PubMed1984

Echocardiographic picture in diabetes mellitus.

The results of echocardiographic examination of 23 diabetics are presented. Significantly increased left ventricular posterior wall thickness and mass and elevated ratio of wall thickness to chamber radius were found in the group of diabetic patients without coronary artery disease and hypertension. The interventricular septum thickness was significantly increased only in the diabetics with hypertension. The possible causes of these findings may be the presence of microangiopathy at the periphery of the coronary circulation or the presence of PAS-positive substances with resulting interstitial fibrosis.

Adult↗
PubMed1984

Acute spasm of vein bypass graft and recipient artery in the immediate postoperative period.

This is a report of an unusual condition in a patient with simultaneous spasms of a vein graft and recipient artery, resulting in acute left ventricular failure in the immediate postoperative period. It is known that coronary artery spasm can complicate perioperative management of the cardiac surgical patient, and spasm of vein bypass grafts themselves can also occur in rare instances. Possible causes of the complication and successful management of this patient are discussed.

Journal Article↗
PubMed1984

Possibilities of two-dimensional echocardiography in cardiomyopathies.

Findings in 20 patients with congestive, in 14 with hypertrophic and in one with restrictive cardiomyopathy are described. In congestive cardiomyopathy, there predominated left ventricular dilatation and diffuse hypokinesis with decreased ejection fraction. The main criteria are reported for differentiating it from advanced diffuse ischaemic heart disease. More detailed characterization is presented of the type of asymmetric septal hypertrophy and of the systolic anterior motion of the mitral apparatus and the possible causes of this finding are discussed. In a patient with restrictive cardiomyopathy there predominated a symmetric thickening of the left ventricle, with diffusely decreased kinetics and increased density of all structures.

Adolescent↗
PubMed1984

Distribution of hypertrophy in obstructive and non-obstructive types of hypertrophic cardiomyopathy.

70 patients with hypertrophic cardiomyopathy were examined by one-dimensional, two-dimensional and pulsed Doppler echocardiography. According to the degree and distribution of hypertrophy in left ventricular (LV) short axis views, the findings were divided into 5 types. In type I, hypertrophy affected only the interventricular septum (10 patients, i.e. 14.2%). In type II, hypertrophy involved besides the septum, also the LV anterior wall (type IIa-26 patients; 37.1%) or lateral wall (type IIb-21 patients; 30.0%). Type III included patients with hypertrophy of the LV posterior wall (3 patients; 4.3%). Six patients (8.5%) had a distinct hypertrophy of the whole apical part of the LV and septum (type IV). Type V was represented by concentric hypertrophy of the LV and septum (4 patients; 5.7%). Hypertrophy of the right ventricular myocardium was found in 6 patients.

Adolescent↗
PubMed1984

Two-dimensional echocardiography in evaluating left ventricular function.

In 65 patients examined by mechanical sector and M-mode echocardiography, left ventricular volumes and ejection fraction were determined. Comparison with biplane ventriculography has shown that the above-mentioned parameters can be determined by sector relatively very reliably. Correlation coefficients for end-diastolic and end-systolic volumes were 0.74 and 0.85 respectively, for the ejection fraction 0.78. Substantially less close correlations were found for parameters obtained by one-dimensional echocardiography, especially in patients with segmental disturbances of kinetics and abnormal left ventricular geometry. The greatest contribution of this laborious and demanding method consists in the possibility of relatively reliable estimation of left ventricular volumes and ejection fraction by two-dimensional echocardiography also in these patients.

Adult↗
PubMed1984

Two-dimensional echocardiography in acute transmural and non-transmural myocardial infarction.

Left ventricular wall motion abnormalities in acute myocardial infarction and their changes during hospitalisation were investigated in 40 patients by means of two-dimensional echocardiography (2-D-E). It was confirmed that two-dimensional echocardiography can detect segmental left ventricular asynergy, follow up its development during hospitalisation and provide on the basis of this information on the extent of infarction. Differences were found between transmural and non-transmural infarctions, in particular as regards the duration of impaired wall motion (in non-transmural infarctions it was only temporary). Suggested indicators of the extent of this disorder ("index of asynergy" and "extent of asynergy") seem to be valuable for the evaluation of the extent of infarction and of its clinical impact. The sensitivity and specificity of echocardiography, as compared with postmortem findings, is satisfactory.

Adult↗
PubMed1984

Diffuse left ventricular hypokinesis in cardiogenic shock--its cause or consequence?

Five patients in cardiogenic shock due to acute myocardial infarction were examined by two-dimensional echocardiography. In one patient, cardiogenic shock developed only after rupture of the interventricular septum, four subjects had "primary" cardiogenic shock. In these four persons there were found extensive disturbances of left ventricular wall motion (the mean extent of the akinetic or dyskinetic zone amounted to 41% of the left ventricle (LV). However, equally extensive (and even larger) disturbances of LV kinetics were found in another 11 patients with acute MI, in whom there did not develop cardiogenic shock. The basic difference between the two groups consisted in the fact that in patients in cardiogenic shock the remaining part of the left ventricle exhibited severe hypokinesis, whereas in other infarcts it was normokinetic or hyperkinetic. Autopsy findings in all patients revealed severe diffuse involvement of all coronary arteries. In the discussion, it is pointed out that the above-mentioned phenomenon (hypokinesis of the "intact" part of the left ventricle) may be both one of the causes of shock as well as merely its consequence.

Echocardiography↗
PubMed1983

Developmental changes in protein carboxylmethylation and in the benzodiazepine receptor proteins in rat brain.

The intraventricular administration of [3H-methyl]-methionine resulted in a steady increase in carboxyl-[3H]methylated protein formation in the brain of developing rats (2-42 days). The analysis by gel filtration on Sepharose-4B of Lubrol-Px-solubilized membrane proteins, including benzodiazepine receptor proteins, revealed co-migration of carboxyl-[3H]methylated and [3H]flunitrazepam-binding protein species. The latter displayed a single peak at 2 days and 2-3 peaks subsequently. At 26 days the lighter of the two [3H]flunitrazepam and [3H]muscimol-binding peaks associated with the principal carboxyl-[3H]-methylated protein peak. The findings suggest the participation of carboxyl-methylation in the maturation of benzodiazepine receptor proteins.

Aging↗