Experience with on-line computer processing of data from an autoanalyser complex.
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Biomedical subjects
Publications and source records attributed to P Gray.
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To expand our crosscultural understanding of erectile dysfunction, we investigated erectile dysfunction among Ariaal men, pastoral nomads of northern Kenya. To measure erectile dysfunction, we administered the International Index of Erectile Function (IIEF-5) to 198 men aged 20 y and older during interviews. Marital status and anthropometric measures of body composition were also obtained. Men were classified into 10-y age groups. ANOVA revealed that erectile dysfunction increases with age (P<0.0005), with men 60 y and older showing significantly higher erectile dysfunction compared with men in their 20s, 40s and 50s. In a MANCOVA model, erectile dysfunction increased with age group (P<0.001), was negatively related to right-hand grip strength (P<0.01) and negatively related to number of wives (P<0.05). In addition, there was a significant interaction between age group and marital status (P<0.01). Erectile dysfunction showed no independent relationship to measures of body composition, including body mass index, fat free mass and percentage body fat. These findings provide further evidence of age-related increases in erectile dysfunction, even when factors commonly associated with erectile dysfunction (eg, metabolic complications of obesity, use of medicines causing erectile dysfunction) are absent. The finding that number of wives is negatively related to erectile dysfunction may represent the specific cultural conditions (political power and wealth) associated with polygyny among the Ariaal.
In order to investigate the effect of prolactin on spermatogenesis, we studied 205 consecutive male patients in whom 121 were normozoospermic (counts greater than 20 x 10(6)/ml), 62 were oligozoospermic (counts less than 20 x 10(6)/ml), and 22 were azoospermic. We compared prolactin with semen analysis. There was an increased incidence of high prolactin levels in the oligozoospermic and azoospermic group of patients. We noted an increase in the number of morphologically normal spermatozoa within the hyperprolactinaemic groups of patients. This may suggest that prolactin plays a regulatory role in spermatogenesis.
We studied 122 normozoospermic, 62 oligozoospermic and 22 azoospermic patients and compared serum testosterone, LH and FSH with semen analysis. Testosterone was similar in all three groups studied. FSH rose significantly in the oligozoospermic and azoospermic groups (p less than 0.01). LH was similar in the normozoospermic and oligozoospermic groups but rose significantly in the azoospermic group (p less than 0,01). The rise in FSH is in accordance with the theory of inhibin release during the maturation states of spermatogenesis. The rise in LH might indicate a separate feedback mechanism mediated by the early stages of spermatogenesis and not by testosterone alone.
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