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Biomedical subjects

P Graw

Publications and source records attributed to P Graw.

42 records · Page 3Linked to original sources
PubMed1976

Intravenous L-5-hydroxytryptophan in normal subjects: an interdisciplinary precursor loading study. Part III: Neuroendocrinological and biochemical changes.

In a precursor study with i.v. 1-5HTP (Ro 3-5940) after peripheral decarboxylase inhibition with benserazide (Ro 4-4602) in healthy human subjects the following biochemical changes were found: 1. Prolactin release was stimulated by benserazide alone, and further stimulated by 1-5HTP (more in women than in men). 2. Basal growth hormone secretion was not affected by benserazide, but was significantly stimulated by 1-5HTP, often to extremely high values. The time course of growth hormone release followed that of mood elevation in 8/11 subjects (and was even correlated in 3), providing data for speculation as to the interrelationships between affective state and neuroendocrinological function. 3. Cortisol levels were higher than normal throughout the experiment, but followed the diurnal decline. A late stimulation of cortisol release after 1-5HTP was observed. 4. The lack of increased platelet serotonin after 1-5HTP indicated efficacious peripheral decarboxylase inhibition by benserazide. 5. Benserazide treatment inhibited platelet MAO activity in certain subjects. Short-term increases in MAO activity after 1-5HTP were observed. 6. 1-5HTP displaced albumin-bound tryptophan by 20%.

5-Hydroxytryptophan↗
PubMed1976

Intravenous L-5-hydroxytryptophan in normal subjects: an interdisciplinary precursor loading study. Part IV: Effects on body temperature and cardiovascular functions.

In 14 healthy subjects the effect of a new soluble 1-5HTP ester (Ro 3-5940) in combination with a peripheral decarboxylase inhibitor on circulatory variables and body temperature was studied. The orthostatic adaptative functions were impaired while no consistent changes were observed in resting parameters. With the exception of an initial rise during infusion, measurements of oral temperature in the group as a whole showed no significant changes. However, if gender was considered, a long-lasting fall of temperature in males (N = 7) and rise in females (n = 6) was observed. The greatest difference between the hypothermic reaction in men and the hyperthermic reaction in women occured two hours after the end of infusion, at the same time where mood effects were most intense. The temperature findings support a modulatory function of central serotoninergic mechanisms in thermoregulation in man and emphasize the importance of sex specific factors in pharmacological studies.

5-Hydroxytryptophan↗
PubMed1976

[Basler drug- and alcohol-questionnaire. First experiences in the construction of a test instrument for evaluation of dependency of drug-and/or alcohol-consumers (author's transl)].

In order to provide an estimation of the degree of drug and/or alcohol dependency the authors designed a questionnaire. In this paper the basic steps of item analysis, factor analysis and calculation of reliability (split-half-method) are reported. After elimination of 6 items out of 65 the item-metric and factorial characteristics as well as the reliability of the instrument could be judged as satisfactory. On the item level two factor analytical solutions were interpreted. The first one showed one factor covering the general concept of dependency, the second one suggested a 3- dimensional differentiation in terms of 1. negative self-concept, 2. obsessional traits, and 3. addictive illness behavior.

Alcoholism↗
PubMedDate not supplied

Long-term follow-up of depression in seasonal affective disorder.

Twenty-six patients diagnosed as having seasonal affective disorder (SAD) completed weekly depression self-ratings for at least 2.5 and up to 8.25 years. Seasonal recurrence of depression persisted in nine patients, seven remitted, four were chronically depressed, and six showed a diffuse pattern. The age at SAD onset and duration of SAD history before entry into this prospective study could not be identified as predictors of the subsequent course of the disease. Short-lasting, recurrent periods of depression could be identified in many of the long-term records. They were found primarily in autumn and winter in patients with either a persistent seasonal or a remitted pattern. In the core group of patients with persistent seasonal pattern, the onset and offset of depressive periods (DPs) were more variable than the DSM-III-R 60-day window criterion for seasonal pattern allows.

Adult↗