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Biomedical subjects

P Grasso

Publications and source records attributed to P Grasso.

At least 127 records · Page 7Linked to original sources
PubMed1978

Short-term toxicity study of Chocolate Brown HT in pigs.

Chocolate Brown HT was given in the diet to groups of 3 male and 3 female pigs at dose levels of 0 (control), 5, 20 or 100 mg/kg/day for 13 weeks. No adverse effects were seen on body weight gain, urine composition of the incidence of histopathological lesions. The haemoglobin levels in all 3 treatment groups of male pigs at week 13 were significantly below the control values, but this effect was not considered to be attributable to treatment with Chocolate Brown HT. The no-untoward-effect level in this study was at least 100 mg/kg/day.

Animals↗
PubMed1978

Long-term toxicity studies on Chocolate Brown HT in rats.

Groups of 48 males and 48 female rats were given diets containing 0 (control), 500, 2000 or 10,000 ppm Chocolate Brown HT for 2 years. These treatments had no adverse effect on mortality, body-weight gain, food or water consumption, haematology, renal function, serum constituents, organ weight or histopathology. From the incidence of tumours observed in the control and test animals it is concluded that Chocolate Brown HT did not exert any carcinogenic effect and that the no-untoward-effect level was 10,000 ppm.

Animals↗
PubMed1978

Metabolism of methylmercuric chloride by the gastro-intestinal flora of the rat.

1. The contents of the caecum and small intestine of the rat metabolized methylmercuric chloride in vitro to a volatile product over a period of 3 to 4 days. The bacterial flora of the gut were responsible for the metabolism. 2. in the presence of caecal contents methylmercury was reduced to metallic mercury. 3. The contents of the small intestine metabolized methylmercuric chloride indirectly, as a result of prior synthesis of H2S to a volatile sulphur derivative of methylmercury.

Animals↗
PubMed1977

The effect of water-soluble chemicals on the growth and mitosis of primary newborn rat kidney cells in culture.

Mass cultures of primary rat kidney cells were exposed briefly to aqueous solutions of 20 chemicals and their subsequent growth rate and mitotic activity measured. Proximate carcinogens, and some chemicals with a defined inhibitory action biochemically, depressed the growth and division of the cultures. Non-carcinogenic compounds and precarcinogens did not interfere with the subsequent growth rate and mitotic activity of the cultures. It is suggested that the possession of growth inhibitory properties could give an indication of the carcinogenic activity of a chemical on a short-term basis.

Animals↗